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Entry version 73 (02 Dec 2020)
Sequence version 1 (08 Apr 2008)
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Protein

von Willebrand factor A domain-containing protein 8

Gene

si:dkey-18l1.1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Exhibits ATPase activity in vitro.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi439 – 446ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
von Willebrand factor A domain-containing protein 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:si:dkey-18l1.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-070912-407, vwa8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 18MitochondrionSequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000034389319 – 1896von Willebrand factor A domain-containing protein 8Sequence analysisAdd BLAST1878

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B0R0T1

PeptideAtlas

More...
PeptideAtlasi
B0R0T1

PRoteomics IDEntifications database

More...
PRIDEi
B0R0T1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000078593, Expressed in muscle organ and 25 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000102255

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B0R0T1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1705 – 1887VWFAPROSITE-ProRule annotationAdd BLAST183

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1808, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006601

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001400_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B0R0T1

Identification of Orthologs from Complete Genome Data

More...
OMAi
VYKRRGM

Database of Orthologous Groups

More...
OrthoDBi
79800at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B0R0T1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR011704, ATPase_dyneun-rel_AAA
IPR027417, P-loop_NTPase
IPR039891, VWA8
IPR002035, VWF_A
IPR036465, vWFA_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR21610, PTHR21610, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07728, AAA_5, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 2 hits
SM00327, VWA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 3 hits
SSF53300, SSF53300, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50234, VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

B0R0T1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHSRILFKGT AAAVAARRIR HILGPLMSKE GWNCSAHEVK LLNTSSGDTV
60 70 80 90 100
KIGEISYVLK TPKNPELVPV NHMMEALPQM VTQHLRWIMQ KDLLGQDVFL
110 120 130 140 150
IGPPGPLRRS IAMQYLELTK REVEYVALSR DTTETDLKQR REIRSGTAFY
160 170 180 190 200
IDQCAVRAAT EGRILVLEGL EKAERNVLPV LNNLLENREM QLEDGRFLMS
210 220 230 240 250
AHRYDKLLEE HTKEELDAWK IVRVSEDFRV IALGLPVPRY KGNPLDPPLR
260 270 280 290 300
SRFQARDIYY LPFKDQLEHL YRIGANVSAE RVSQLLSFAT TLCSQESASL
310 320 330 340 350
SLPDFPVDNL PSALTVLNLF PMLSVQQLVQ RLYPYEAMLG KEGRTAVEGV
360 370 380 390 400
LNRFELTDGS TKPSPTAVVN IEPVNGGQAE QAAVTLNITN QKITFQVPSG
410 420 430 440 450
TRPIRPPNSS PTFINTPTHE RLLAEMMQSH LVKDICLIGA KGCGKSVIAR
460 470 480 490 500
EFAEMLGYSI EPVMLYQDMT ARDLLQQRYT LPNGDTAWRA SPLVTAAQEG
510 520 530 540 550
KLVLLDGIHR VNLGTLAVLS RLLHDRELDL YDGTRLLRFD RYQALKEELQ
560 570 580 590 600
LTDQQLQDRS IFPIHPSFRI IALAEPPVIG STTQQWLNPE ILTMFLFHTI
610 620 630 640 650
KPLAKAEETA VLQGMIPNVP GEAVEQLQHL THSLRKSNDP TALSLASSLS
660 670 680 690 700
TRQLLRICRR LSQYPQESVA HAVHKACLSR FLPSLARSSL EKSLANCSIE
710 720 730 740 750
DHPDPASEQK QLYTCTVKDG LLTIGNVSAP VYSPDEKMKV PDVLFYENVQ
760 770 780 790 800
HMMVMQDMLK DFLLGEHLLL VGNQGVGKNK IVDRFLHLMN RPREYLQLHR
810 820 830 840 850
DTTVQTLTLQ PSVRDGIIIY EDSPLVKAVK MGHILVIDEA DKAPTNVTCI
860 870 880 890 900
LKALVESGEM ILADGRRIVS DALEAAGRPN AIPMHPDFRM IVLANRPGFP
910 920 930 940 950
FLGNDFFGAL GDIFSCHAVD NPKPQAEFAM LKQYGPDVPD AVLQKLVAAF
960 970 980 990 1000
GELRAMADQG TITYPYSTRE VVNIVKHLQK FPDEGLANVV RNVFDFDSYN
1010 1020 1030 1040 1050
KDMREVLISA LHKHGIPIGA KPTSVHLAKE LPLPDCKMTG YWTISQGGNT
1060 1070 1080 1090 1100
RRKLLCPTET HRIDIKGPVF LRVQSYPSKR HESRSLSFTE EQAHWQIPMN
1110 1120 1130 1140 1150
EVNIVCDVTT AKDSIYVATC NPVSLYAMKE KGDSVQCIEL YDIFPRTISG
1160 1170 1180 1190 1200
VWQPFVSVAA LGNPLQDQVV LHEEQGNTVL HLDLVTGAVR RLILSQDKQD
1210 1220 1230 1240 1250
EAPRKTSNWW NSKESQPGYK MCKEFAHKNW LLFYKENGNQ LDVVDVLEGQ
1260 1270 1280 1290 1300
VHTIHLPINL KAVFLVAEDR WLLVESKTDR KFLLTKPMHM GAEETGVCQL
1310 1320 1330 1340 1350
HAISEDAVSS GFGNNSGMEA VSPQEVSSDQ LSNENLSAAL GQKIVSPNRI
1360 1370 1380 1390 1400
LCDTNTYANV IVGFPDLMSP NELYSFRRSL PITESRRPDM FFGSSKRTGP
1410 1420 1430 1440 1450
AKRVNCVCLL DANQVVRALP PTQVPLAEVY PKDVTPPMSA AYLEVTDLNS
1460 1470 1480 1490 1500
KRLKYIPVPR SNSMSPYTVW ISKVSDTDVV MAPLGSGGVV TVDMGGYVRL
1510 1520 1530 1540 1550
WETGLDHLQR SLLEWRNMIG SEDGRPVQIT IERDSGLDVS SPKHGKIDAK
1560 1570 1580 1590 1600
NAPHVGGNQW AGGTGGRDTA GLGGKGGPYR LDAGHKVYQI SQAEKDAVPD
1610 1620 1630 1640 1650
EVKRAARDMA EQAFKQRLKE IEMSEYDAST YDRFSGAVRR QVQSLRIILD
1660 1670 1680 1690 1700
SLQAKGKERQ WLRNQALGEL DDAKIIDGLT GEKSIYKRRG ELEPELGSPQ
1710 1720 1730 1740 1750
QKPKRLRVLA DVSGSMYRFN GVDGRLERSM EAVCMVMEAL ESYEHKFKYD
1760 1770 1780 1790 1800
ITGHSGDGFD IELVRCDKVP KNNKERLKVL KTMHAHSQFC MSGDYTLEGT
1810 1820 1830 1840 1850
EHAIRELAHE EADEHFVIVL SDANLERYGI SPDRFARVLT SNPQVNAFAI
1860 1870 1880 1890
FIGSLGDQAD RLQKTLPAGR SFVAMDTKEI PQILQQIFTS TMLSSA
Length:1,896
Mass (Da):211,974
Last modified:April 8, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iACEA6E2174BB1FAE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Q9X7A0A2R8Q9X7_DANRE
von Willebrand factor A domain-cont...
vwa8
1,904Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8RYA1A0A2R8RYA1_DANRE
von Willebrand factor A domain-cont...
vwa8
1,904Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX649198, AL929161 Genomic DNA Translation: CAQ14217.1
AL929161, BX649198 Genomic DNA Translation: CAQ14674.1

NCBI Reference Sequences

More...
RefSeqi
NP_001121810.1, NM_001128338.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000146706; ENSDARP00000120404; ENSDARG00000078593

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
561317

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:561317

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX649198, AL929161 Genomic DNA Translation: CAQ14217.1
AL929161, BX649198 Genomic DNA Translation: CAQ14674.1
RefSeqiNP_001121810.1, NM_001128338.1

3D structure databases

SMRiB0R0T1
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000102255

Proteomic databases

PaxDbiB0R0T1
PeptideAtlasiB0R0T1
PRIDEiB0R0T1

Genome annotation databases

EnsembliENSDART00000146706; ENSDARP00000120404; ENSDARG00000078593
GeneIDi561317
KEGGidre:561317

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23078
ZFINiZDB-GENE-070912-407, vwa8

Phylogenomic databases

eggNOGiKOG1808, Eukaryota
GeneTreeiENSGT00390000006601
HOGENOMiCLU_001400_0_0_1
InParanoidiB0R0T1
OMAiVYKRRGM
OrthoDBi79800at2759
PhylomeDBiB0R0T1

Miscellaneous databases

Protein Ontology

More...
PROi
PR:B0R0T1

Gene expression databases

BgeeiENSDARG00000078593, Expressed in muscle organ and 25 other tissues

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR011704, ATPase_dyneun-rel_AAA
IPR027417, P-loop_NTPase
IPR039891, VWA8
IPR002035, VWF_A
IPR036465, vWFA_dom_sf
PANTHERiPTHR21610, PTHR21610, 1 hit
PfamiView protein in Pfam
PF07728, AAA_5, 3 hits
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SM00327, VWA, 1 hit
SUPFAMiSSF52540, SSF52540, 3 hits
SSF53300, SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50234, VWFA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVWA8_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B0R0T1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: April 8, 2008
Last modified: December 2, 2020
This is version 73 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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