UniProtKB - B0QZ43 (B0QZ43_HUMAN)
Protein
Submitted name:
Erlin-1
Gene
ERLIN1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- ubiquitin protein ligase binding Source: InterPro
GO - Biological processi
- steroid metabolic process Source: UniProtKB-KW
Keywordsi
Biological process | Lipid metabolism, Steroid metabolism, Sterol metabolismARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Erlin-1Imported |
Gene namesi | Name:ERLIN1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16947, ERLIN1 |
VEuPathDBi | HostDB:ENSG00000107566.13 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type II membrane protein ARBA annotation
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB-KW
Other locations
- integral component of membrane Source: UniProtKB-KW
Keywords - Cellular componenti
Endoplasmic reticulumARBA annotation, MembranePTM / Processingi
Keywords - PTMi
GlycoproteinARBA annotationProteomic databases
EPDi | B0QZ43 |
MaxQBi | B0QZ43 |
PeptideAtlasi | B0QZ43 |
PRIDEi | B0QZ43 |
ProteomicsDBi | 2726 |
Expressioni
Gene expression databases
Bgeei | ENSG00000107566, Expressed in endometrium and 245 other tissues |
ExpressionAtlasi | B0QZ43, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 189 | PHBInterPro annotationAdd BLAST | 167 |
Sequence similaritiesi
Belongs to the band 7/mec-2 family.ARBA annotation
Keywords - Domaini
Signal-anchorARBA annotation, Transmembrane, Transmembrane helixARBA annotationPhylogenomic databases
GeneTreei | ENSGT00390000014666 |
HOGENOMi | CLU_058701_0_0_1 |
Family and domain databases
CDDi | cd03406, SPFH_like_u3, 1 hit |
InterProi | View protein in InterPro IPR001107, Band_7 IPR036013, Band_7/SPFH_dom_sf IPR033294, Erlin1/2 |
PANTHERi | PTHR15351, PTHR15351, 1 hit |
Pfami | View protein in Pfam PF01145, Band_7, 1 hit |
SMARTi | View protein in SMART SM00244, PHB, 1 hit |
SUPFAMi | SSF117892, SSF117892, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
B0QZ43-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNMTQARVLV AAVVGLVAVL LYASIHKIEE GHLAVYYRGG ALLTSPSGPG
60 70 80 90 100
YHIMLPFITT FRSVQTTLQT DEVKNVPCGT SGGVMIYIDR IEVVNMLAPY
110 120 130 140 150
AVFDIVRNYT ADYDKTLIFN KIHHELNQFC SAHTLQEVYI ELFDQIDENL
160 170 180 190 200
KQALQKDLNL MAPGLTIQAV RVTKPKIPEA IRRNFELMEA EKTKLLIAAQ
210 220 230 240 250
KQKVVEKEAE TERKKAVIEA EKIAQVAKIR FQQKVMEKET EKRISEIEDA
260 270
AFLAREKAKA DAEYYAAHKY ATSNK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketO75477 | ERLN1_HUMAN | Erlin-1 | ERLIN1 C10orf69, KE04, KEO4, SPFH1 | 348 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 275 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL138921 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000370408; ENSP00000359436; ENSG00000107566 |
UCSCi | uc057vio.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL138921 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
EPDi | B0QZ43 |
MaxQBi | B0QZ43 |
PeptideAtlasi | B0QZ43 |
PRIDEi | B0QZ43 |
ProteomicsDBi | 2726 |
Protocols and materials databases
Antibodypediai | 2279, 197 antibodies |
Genome annotation databases
Ensembli | ENST00000370408; ENSP00000359436; ENSG00000107566 |
UCSCi | uc057vio.1, human |
Organism-specific databases
HGNCi | HGNC:16947, ERLIN1 |
OpenTargetsi | ENSG00000107566 |
VEuPathDBi | HostDB:ENSG00000107566.13 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000014666 |
HOGENOMi | CLU_058701_0_0_1 |
Miscellaneous databases
ChiTaRSi | ERLIN1, human |
Gene expression databases
Bgeei | ENSG00000107566, Expressed in endometrium and 245 other tissues |
ExpressionAtlasi | B0QZ43, baseline and differential |
Family and domain databases
CDDi | cd03406, SPFH_like_u3, 1 hit |
InterProi | View protein in InterPro IPR001107, Band_7 IPR036013, Band_7/SPFH_dom_sf IPR033294, Erlin1/2 |
PANTHERi | PTHR15351, PTHR15351, 1 hit |
Pfami | View protein in Pfam PF01145, Band_7, 1 hit |
SMARTi | View protein in SMART SM00244, PHB, 1 hit |
SUPFAMi | SSF117892, SSF117892, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B0QZ43_HUMAN | |
Accessioni | B0QZ43Primary (citable) accession number: B0QZ43 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 8, 2008 |
Last sequence update: | April 8, 2008 | |
Last modified: | February 10, 2021 | |
This is version 79 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |