UniProtKB - B0QYW7 (B0QYW7_HUMAN)
Protein
Submitted name:
Estrogen receptor
Gene
ESR1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity Source: InterPro
- sequence-specific DNA binding Source: InterPro
- zinc ion binding Source: InterPro
Keywordsi
Molecular function | DNA-bindingARBA annotation, ReceptorARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Estrogen receptorImported |
Gene namesi | Name:ESR1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3467, ESR1 |
VEuPathDBi | HostDB:ENSG00000091831.21 |
Subcellular locationi
Nucleus
- nucleus Source: UniProtKB-KW
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000091831, Expressed in endometrium and 168 other tissues |
ExpressionAtlasi | B0QYW7, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 107 | NR LBDInterPro annotationAdd BLAST | 107 | |
Domaini | 1 – 42 | Nuclear receptorInterPro annotationAdd BLAST | 42 |
Keywords - Domaini
Zinc-fingerARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000158133 |
HOGENOMi | CLU_2215851_0_0_1 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
SMARTi | View protein in SMART SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
B0QYW7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
HNDYMCPATN QCTIDKNRRK SCQACRLRKC YEVGMMKGGF VDLTLHDQVH
60 70 80 90 100
LLECAWLEIL MIGLVWRSME HPGKLLFAPN LLLDRNQGKC VEGMVEIFDM
LLATSSR
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP03372 | ESR1_HUMAN | Estrogen receptor | ESR1 ESR, NR3A1 | 595 | Annotation score: | ||
Q9H2M1 | Q9H2M1_HUMAN | ER-alpha | ESR1 | 334 | Annotation score: | ||
H0Y4W6 | H0Y4W6_HUMAN | Estrogen receptor | ESR1 | 310 | Annotation score: | ||
Q9UE35 | Q9UE35_HUMAN | Estrogen receptor | ESR1 estrogen receptor | 115 | Annotation score: | ||
Q5T5H8 | Q5T5H8_HUMAN | Estrogen receptor | ESR1 | 84 | Annotation score: | ||
Q9H2M2 | Q9H2M2_HUMAN | Estrogen receptor | ESR1 | 152 | Annotation score: | ||
A0A1W2PP92 | A0A1W2PP92_HUMAN | Estrogen receptor | ESR1 | 44 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 | |
Non-terminal residuei | 107 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL035695 Genomic DNA No translation available. AL049821 Genomic DNA No translation available. AL356311 Genomic DNA No translation available. AL590993 Genomic DNA No translation available. KF454881 Genomic DNA No translation available. KF458326 Genomic DNA No translation available. KF458327 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000415488; ENSP00000401995; ENSG00000091831 |
UCSCi | uc063sho.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL035695 Genomic DNA No translation available. AL049821 Genomic DNA No translation available. AL356311 Genomic DNA No translation available. AL590993 Genomic DNA No translation available. KF454881 Genomic DNA No translation available. KF458326 Genomic DNA No translation available. KF458327 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | B0QYW7 |
PRIDEi | B0QYW7 |
ProteomicsDBi | 2706 |
Protocols and materials databases
Antibodypediai | 739, 4045 antibodies |
Genome annotation databases
Ensembli | ENST00000415488; ENSP00000401995; ENSG00000091831 |
UCSCi | uc063sho.1, human |
Organism-specific databases
HGNCi | HGNC:3467, ESR1 |
OpenTargetsi | ENSG00000091831 |
VEuPathDBi | HostDB:ENSG00000091831.21 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000158133 |
HOGENOMi | CLU_2215851_0_0_1 |
Miscellaneous databases
ChiTaRSi | ESR1, human |
Gene expression databases
Bgeei | ENSG00000091831, Expressed in endometrium and 168 other tissues |
ExpressionAtlasi | B0QYW7, baseline and differential |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
SMARTi | View protein in SMART SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B0QYW7_HUMAN | |
Accessioni | B0QYW7Primary (citable) accession number: B0QYW7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 8, 2008 |
Last sequence update: | April 8, 2008 | |
Last modified: | April 7, 2021 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |