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Protein

DNA repair protein RAD51 homolog

Gene

pigRAD51

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SSC-5685938 HDR through Single Strand Annealing (SSA)
R-SSC-5685942 HDR through Homologous Recombination (HRR)
R-SSC-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
R-SSC-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-SSC-5693579 Homologous DNA Pairing and Strand Exchange
R-SSC-5693616 Presynaptic phase of homologous DNA pairing and strand exchange

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein RAD51 homologUniRule annotation
Gene namesi
Name:pigRAD51Imported
Synonyms:RAD51Imported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Expressioni

Gene expression databases

BgeeiENSSSCG00000004766 Expressed in 5 organ(s), highest expression level in lung

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000005138

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini98 – 269RECA_2InterPro annotationAdd BLAST172
Domaini276 – 339RECA_3InterPro annotationAdd BLAST64

Sequence similaritiesi

Belongs to the RecA family. RAD51 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1433 Eukaryota
COG0468 LUCA
GeneTreeiENSGT00890000139508
HOGENOMiHOG000227426
HOVERGENiHBG001504
KOiK04482
OMAiYNTDHQT
OrthoDBiEOG091G09QY
TreeFamiTF101218

Family and domain databases

CDDicd01123 Rad51_DMC1_radA, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011941 DNA_recomb/repair_Rad51
IPR013632 DNA_recomb/repair_Rad51_C
IPR016467 DNA_recomb/repair_RecA-like
IPR010995 DNA_repair_Rad51/TF_NusA_a-hlx
IPR027417 P-loop_NTPase
IPR033925 Rad51_DMC1_RadA
IPR020588 RecA_ATP-bd
IPR020587 RecA_monomer-monomer_interface
PfamiView protein in Pfam
PF08423 Rad51, 1 hit
PIRSFiPIRSF005856 Rad51, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF47794 SSF47794, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR02239 recomb_RAD51, 1 hit
PROSITEiView protein in PROSITE
PS50162 RECA_2, 1 hit
PS50163 RECA_3, 1 hit

Sequencei

Sequence statusi: Complete.

B0M1M6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVQMQLESN ADTSVEEESF GPQPISRLEQ CGINANDVKK LEEAGFHTVE
60 70 80 90 100
AVAYAPKKEL INIKGISEAK ADKILTEAAK LVPMGFTTAT EFHQRRSEII
110 120 130 140 150
QITTGSKELD KLLQGGIETG SITEMFGEFR TGKTQICHTL AVTCQLPIDR
160 170 180 190 200
GGGEGKAMYI DTEGTFRPER LLAVAERYGL SGSDVLDNVA YARAFNTDHQ
210 220 230 240 250
TQLLYQASAM MVESRYALLI IDSATALYRT DYSGRGELSA RQMHLARFLR
260 270 280 290 300
MLLRLADEFG VAVVITNQVV AQVDGAAMFA ADPKKPIGGN IIAHASTTRL
310 320 330
YLRKGRGETR ICKIYDSPCL PEAEAMFAIN ADGVGDAKD
Length:339
Mass (Da):36,994
Last modified:April 8, 2008 - v1
Checksum:iCBE3582048B63A3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000004 Genomic DNA No translation available.
EU302125 mRNA Translation: ABZ89107.1
AB355632 mRNA Translation: BAG09486.1
RefSeqiNP_001116653.1, NM_001123181.1
UniGeneiSsc.22664

Genome annotation databases

EnsembliENSSSCT00000005265; ENSSSCP00000005138; ENSSSCG00000004766
GeneIDi100141309
KEGGissc:100141309

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000004 Genomic DNA No translation available.
EU302125 mRNA Translation: ABZ89107.1
AB355632 mRNA Translation: BAG09486.1
RefSeqiNP_001116653.1, NM_001123181.1
UniGeneiSsc.22664

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000005138

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000005265; ENSSSCP00000005138; ENSSSCG00000004766
GeneIDi100141309
KEGGissc:100141309

Organism-specific databases

CTDi5888

Phylogenomic databases

eggNOGiKOG1433 Eukaryota
COG0468 LUCA
GeneTreeiENSGT00890000139508
HOGENOMiHOG000227426
HOVERGENiHBG001504
KOiK04482
OMAiYNTDHQT
OrthoDBiEOG091G09QY
TreeFamiTF101218

Enzyme and pathway databases

ReactomeiR-SSC-5685938 HDR through Single Strand Annealing (SSA)
R-SSC-5685942 HDR through Homologous Recombination (HRR)
R-SSC-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
R-SSC-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-SSC-5693579 Homologous DNA Pairing and Strand Exchange
R-SSC-5693616 Presynaptic phase of homologous DNA pairing and strand exchange

Gene expression databases

BgeeiENSSSCG00000004766 Expressed in 5 organ(s), highest expression level in lung

Family and domain databases

CDDicd01123 Rad51_DMC1_radA, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011941 DNA_recomb/repair_Rad51
IPR013632 DNA_recomb/repair_Rad51_C
IPR016467 DNA_recomb/repair_RecA-like
IPR010995 DNA_repair_Rad51/TF_NusA_a-hlx
IPR027417 P-loop_NTPase
IPR033925 Rad51_DMC1_RadA
IPR020588 RecA_ATP-bd
IPR020587 RecA_monomer-monomer_interface
PfamiView protein in Pfam
PF08423 Rad51, 1 hit
PIRSFiPIRSF005856 Rad51, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF47794 SSF47794, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR02239 recomb_RAD51, 1 hit
PROSITEiView protein in PROSITE
PS50162 RECA_2, 1 hit
PS50163 RECA_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB0M1M6_PIG
AccessioniPrimary (citable) accession number: B0M1M6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: October 10, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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