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Entry version 78 (07 Oct 2020)
Sequence version 1 (18 Mar 2008)
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Protein

DNA damage-binding protein 1

Gene

repE

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in DNA repair. May be a component of an E3 ubiquitin-protein ligase which promotes histone ubiquitination in response to UV irradiation. Histone ubiquitination may be important for subsequent DNA repair (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • damaged DNA binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA repair

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DDI-5696394, DNA Damage Recognition in GG-NER
R-DDI-5696395, Formation of Incision Complex in GG-NER
R-DDI-6781823, Formation of TC-NER Pre-Incision Complex
R-DDI-6782135, Dual incision in TC-NER
R-DDI-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER
R-DDI-8951664, Neddylation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA damage-binding protein 1
Alternative name(s):
DNA repair protein E
UV-damaged DNA-binding protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:repE
Synonyms:ddb1
ORF Names:DDB_G0286013
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyosteliaDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0286013, repE

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003760071 – 1181DNA damage-binding protein 1Add BLAST1181

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B0M0P5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Levels accumulate after the removal of the food source and increase with the onset of development (accumulation at 1-3 hours) peaking at 5-7 hours of development and declining abruptly. Not expressed by mitotically dividing cells. Not measurable during vegetative growth on bacteria.3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated in response to UV-damage followed by an increase in transcription back to basal level. Shows slight increase in transcription following cisplatin treatment.3 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0191144

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi152 – 186Poly-AsnAdd BLAST35
Compositional biasi445 – 467Poly-AsnAdd BLAST23
Compositional biasi877 – 884Poly-Ser8
Compositional biasi892 – 899Poly-Asn8

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DDB1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1897, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002893_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B0M0P5

KEGG Orthology (KO)

More...
KOi
K10610

Identification of Orthologs from Complete Genome Data

More...
OMAi
GDGSMYY

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B0M0P5

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004871, Cleavage/polyA-sp_fac_asu_C
IPR031297, DDB1
IPR011047, Quinoprotein_ADH-like_supfam
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR036322, WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10644:SF3, PTHR10644:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03178, CPSF_A, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978, SSF50978, 2 hits
SSF50998, SSF50998, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B0M0P5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYNFVSTVQK PTSVTHSVTG NFTGPNDKNL IISKCTKIEI FLMDQDGLKP
60 70 80 90 100
MFDVNIYGRI SVLKLFSVAG SKQDYLFIST ESFKFCILAY DYEKKEIITK
110 120 130 140 150
ASGNAEDTIG RPTEAGQLGI IDPDGRIVAL HLYEGLLKLI TLDNNNTPNK
160 170 180 190 200
INNNNNNNNN NNNNNNNNNN NNINNNNFNI NNNNNNSPIQ KNVNNVRLEE
210 220 230 240 250
LQVLDMTFLY GCKVPTIAVL FKDTKDEKHI STYEISSKDT ELVVGPWSQS
260 270 280 290 300
NVGVYSSLLV PVPLGGVLVV ADNGITYLNG KVTRSVAVSY TKFLAFTRVD
310 320 330 340 350
KDGSRFLFGD HFGRLSVLVL IHQQQKVMEL KFEQLGRISI PSSISYLDSG
360 370 380 390 400
VVYIGSSSGD SQLIRLNTEK DQTTDSYVTY LEAFTNIGPV VDFCVVDAEK
410 420 430 440 450
QGQAQIVTCS GTYRDGSLRI IRNGIGIAEQ ASIELEGIKG IFPINNNNNN
460 470 480 490 500
NNNNNNNNNN NNNNNSNGIT DSKDRYLITS FIECTKVLSF QGEEIEETEF
510 520 530 540 550
EGLESNCSTL YCGTIDKLNL LIQITNVSIN LIDSNTFKRV SQWNVEPSRR
560 570 580 590 600
INLVSTNQDQ IVLSIDKSLL YFQINSSNKS IQLVKEIELP HEISCIDISP
610 620 630 640 650
FDSFMDTKSQ LVSVGLWNDI TLRIFKLPTL EEIWKEPLGG EILPRSILMI
660 670 680 690 700
SFDSIDYIFC SLGDGHLFKF QFDFSSFKLF DKRKLTLGTQ PIILKKFKLK
710 720 730 740 750
NTINIFAISD RPTVIYSHNK KLFYSVVNLK DVTNVTSFNS DGFPNSMAIA
760 770 780 790 800
TTNSLTIGTI DEIQKLHIKT IPLNEEMGRR IVHLEDHSCY AVITVKNNEG
810 820 830 840 850
LLGGAQDLCE EDEEVSYIRI YNDQTFELIS SYKLDPYEMG WSITPCKFAG
860 870 880 890 900
DDVNTYLAVG TSINTPIKSS GRVLLFSLSS SSSSNDKDSL DNNNNNNNNS
910 920 930 940 950
GANGKLTLLE EIKFRSSVYF LLSFNGRLIA AVHKRLFSIR YTHSKEKNCK
960 970 980 990 1000
VISSESVHKG HTMILKLASR GHFILVGDMM KSMSLLVEQS DGSLEQIARN
1010 1020 1030 1040 1050
PQPIWIRSVA MINDDYFIGA EASNNFIVVK KNNDSTNELE RELLDSVGHY
1060 1070 1080 1090 1100
HIGESINSMR HGSLVRLPDS DQPIIPTILY ASVNGSIGVV ASISEEDFIF
1110 1120 1130 1140 1150
FSKLQKGLNQ VVRGVGGFSH ETWRAFSNDH HTIDSKNFID GDLIETFLDL
1160 1170 1180
KYESQLKAVA DLGITPDDAF RRIESLMQYI R
Length:1,181
Mass (Da):132,254
Last modified:March 18, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB05F8B5B66FB77B8
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC47162 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U50042 Genomic DNA Translation: AAC47162.1 Sequence problems.
AAFI02000085 Genomic DNA Translation: EAL64385.2

Protein sequence database of the Protein Information Resource

More...
PIRi
S71092

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL64385; EAL64385; DDB_G0286013

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0286013

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50042 Genomic DNA Translation: AAC47162.1 Sequence problems.
AAFI02000085 Genomic DNA Translation: EAL64385.2
PIRiS71092

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi44689.DDB0191144

Proteomic databases

PaxDbiB0M0P5

Genome annotation databases

EnsemblProtistsiEAL64385; EAL64385; DDB_G0286013
KEGGiddi:DDB_G0286013

Organism-specific databases

dictyBaseiDDB_G0286013, repE

Phylogenomic databases

eggNOGiKOG1897, Eukaryota
HOGENOMiCLU_002893_0_1_1
InParanoidiB0M0P5
KOiK10610
OMAiGDGSMYY
PhylomeDBiB0M0P5

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-DDI-5696394, DNA Damage Recognition in GG-NER
R-DDI-5696395, Formation of Incision Complex in GG-NER
R-DDI-6781823, Formation of TC-NER Pre-Incision Complex
R-DDI-6782135, Dual incision in TC-NER
R-DDI-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER
R-DDI-8951664, Neddylation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:B0M0P5

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR004871, Cleavage/polyA-sp_fac_asu_C
IPR031297, DDB1
IPR011047, Quinoprotein_ADH-like_supfam
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR036322, WD40_repeat_dom_sf
PANTHERiPTHR10644:SF3, PTHR10644:SF3, 1 hit
PfamiView protein in Pfam
PF03178, CPSF_A, 1 hit
SUPFAMiSSF50978, SSF50978, 2 hits
SSF50998, SSF50998, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDDB1_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B0M0P5
Secondary accession number(s): Q23865
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: March 18, 2008
Last modified: October 7, 2020
This is version 78 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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