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Entry version 106 (02 Jun 2021)
Sequence version 1 (18 Mar 2008)
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Protein
Submitted name:

NF-kappaB transcription factor p65 subunit

Gene

RELA

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SSC-1169091, Activation of NF-kappaB in B cells
R-SSC-1810476, RIP-mediated NFkB activation via ZBP1
R-SSC-193692, Regulated proteolysis of p75NTR
R-SSC-202424, Downstream TCR signaling
R-SSC-209560, NF-kB is activated and signals survival
R-SSC-2871837, FCERI mediated NF-kB activation
R-SSC-3134963, DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-SSC-3214841, PKMTs methylate histone lysines
R-SSC-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-SSC-4755510, SUMOylation of immune response proteins
R-SSC-5607764, CLEC7A (Dectin-1) signaling
R-SSC-5621575, CD209 (DC-SIGN) signaling
R-SSC-9020702, Interleukin-1 signaling
R-SSC-933542, TRAF6 mediated NF-kB activation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
NF-kappaB transcription factor p65 subunitImported
Submitted name:
RELA proto-oncogene, NF-kB subunitImported
Submitted name:
Transcription factor p65Imported
Submitted name:
Transcription factor p65 isoform 1Imported
Submitted name:
p65Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RELAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008227 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:92203, RELA

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
B0LXP3

PRoteomics IDEntifications database

More...
PRIDEi
B0LXP3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSSSCG00000027479, Expressed in blood and 24 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
B0LXP3, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9823.ENSSSCP00000013805

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B0LXP3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 190RHDInterPro annotationAdd BLAST175

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni41 – 60DisorderedSequence analysisAdd BLAST20
Regioni314 – 347DisorderedSequence analysisAdd BLAST34
Regioni507 – 527DisorderedSequence analysisAdd BLAST21

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QT4Z, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159867

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004343_5_1_1

Database of Orthologous Groups

More...
OrthoDBi
916931at2759

TreeFam database of animal gene trees

More...
TreeFami
TF325632

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01177, IPT_NFkappaB, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
2.60.40.340, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR033926, IPT_NFkappaB
IPR000451, NFkB/Dor
IPR008967, p53-like_TF_DNA-bd
IPR030495, RelA
IPR030492, RHD_CS
IPR032397, RHD_dimer
IPR011539, RHD_DNA_bind_dom
IPR037059, RHD_DNA_bind_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR24169, PTHR24169, 1 hit
PTHR24169:SF1, PTHR24169:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16179, RHD_dimer, 1 hit
PF00554, RHD_DNA_bind, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00057, NFKBTNSCPFCT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00429, IPT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49417, SSF49417, 1 hit
SSF81296, SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01204, REL_1, 1 hit
PS50254, REL_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

B0LXP3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDDLFPLIFP SEPAPASGPY VEIIEQPKQR GMRFRYKCEG RSAGSIPGER
60 70 80 90 100
STDTTKTHPT IKINGYTGPG TVRISLVTKD PPHRPHPHEL VGKDCRDGFY
110 120 130 140 150
EAELCPDRCI HSFQNLGIQC VKKRDLEQAI NQRIQTNNNP FQVPIEEQRG
160 170 180 190 200
DYDLNAVRLC FQVTVRDPAG RPLRLPPVLS HPIFDNRAPN TAELKICRVN
210 220 230 240 250
RNSGSCLGGD EIFLLCDKVQ KEDIEVYFTG PGWEARGSFS QADVHRQVAI
260 270 280 290 300
VFRTPPYADP SLQAPVRVSM QLRRPSDREL SEPMEFQYLP DTDDRHRIEE
310 320 330 340 350
KRKRTYETFK SIMKKSPFNG PTDPRPATRR IAVPSRSSAS VPKPAPQPYP
360 370 380 390 400
FTPSLSTINF DEFTPMAFAS GQIPGQTSAL APAPAPVLVQ APAPAPAPAM
410 420 430 440 450
ASALAQAPAP VPVLAPGLAQ AVAPPAPKTN QAGEGTLTEA LLQLQFDTDE
460 470 480 490 500
DLGALLGNNT DPTVFTDLAS VDNSEFQQLL NQGVSMPPHT AEPMLMEYPE
510 520 530 540 550
AITRLVTGSQ RPPDPAPTPL GASGLTNGLL SGDEDFSSIA DMDFSALLSQ

ISS
Length:553
Mass (Da):60,383
Last modified:March 18, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i60B115EF4DC505F0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6PVF4F6PVF4_PIG
RELA proto-oncogene, NF-kB subunit
RELA
573Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286ZJ10A0A286ZJ10_PIG
RELA proto-oncogene, NF-kB subunit
RELA
449Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AEMK02000006 Genomic DNA No translation available.
EU399817 mRNA Translation: ABY81295.1
KC316023 mRNA Translation: AGH25608.1
KY369935 mRNA Translation: ATV90884.1
DQIR01257747 Transcribed RNA Translation: HDC13225.1
DQIR01285838 Transcribed RNA Translation: HDC41316.1

NCBI Reference Sequences

More...
RefSeqi
NP_001107753.1, NM_001114281.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSSCT00000029216; ENSSSCP00000028005; ENSSSCG00000012981

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100135665

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ssc:100135665

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000006 Genomic DNA No translation available.
EU399817 mRNA Translation: ABY81295.1
KC316023 mRNA Translation: AGH25608.1
KY369935 mRNA Translation: ATV90884.1
DQIR01257747 Transcribed RNA Translation: HDC13225.1
DQIR01285838 Transcribed RNA Translation: HDC41316.1
RefSeqiNP_001107753.1, NM_001114281.1

3D structure databases

SMRiB0LXP3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000013805

Proteomic databases

PeptideAtlasiB0LXP3
PRIDEiB0LXP3

Genome annotation databases

EnsembliENSSSCT00000029216; ENSSSCP00000028005; ENSSSCG00000012981
GeneIDi100135665
KEGGissc:100135665

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5970
VGNCiVGNC:92203, RELA

Phylogenomic databases

eggNOGiENOG502QT4Z, Eukaryota
GeneTreeiENSGT00940000159867
HOGENOMiCLU_004343_5_1_1
OrthoDBi916931at2759
TreeFamiTF325632

Enzyme and pathway databases

ReactomeiR-SSC-1169091, Activation of NF-kappaB in B cells
R-SSC-1810476, RIP-mediated NFkB activation via ZBP1
R-SSC-193692, Regulated proteolysis of p75NTR
R-SSC-202424, Downstream TCR signaling
R-SSC-209560, NF-kB is activated and signals survival
R-SSC-2871837, FCERI mediated NF-kB activation
R-SSC-3134963, DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-SSC-3214841, PKMTs methylate histone lysines
R-SSC-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-SSC-4755510, SUMOylation of immune response proteins
R-SSC-5607764, CLEC7A (Dectin-1) signaling
R-SSC-5621575, CD209 (DC-SIGN) signaling
R-SSC-9020702, Interleukin-1 signaling
R-SSC-933542, TRAF6 mediated NF-kB activation

Gene expression databases

BgeeiENSSSCG00000027479, Expressed in blood and 24 other tissues
ExpressionAtlasiB0LXP3, baseline and differential

Family and domain databases

CDDicd01177, IPT_NFkappaB, 1 hit
Gene3Di2.60.40.10, 1 hit
2.60.40.340, 1 hit
InterProiView protein in InterPro
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR033926, IPT_NFkappaB
IPR000451, NFkB/Dor
IPR008967, p53-like_TF_DNA-bd
IPR030495, RelA
IPR030492, RHD_CS
IPR032397, RHD_dimer
IPR011539, RHD_DNA_bind_dom
IPR037059, RHD_DNA_bind_dom_sf
PANTHERiPTHR24169, PTHR24169, 1 hit
PTHR24169:SF1, PTHR24169:SF1, 1 hit
PfamiView protein in Pfam
PF16179, RHD_dimer, 1 hit
PF00554, RHD_DNA_bind, 1 hit
PRINTSiPR00057, NFKBTNSCPFCT
SMARTiView protein in SMART
SM00429, IPT, 1 hit
SUPFAMiSSF49417, SSF49417, 1 hit
SSF81296, SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS01204, REL_1, 1 hit
PS50254, REL_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB0LXP3_PIG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B0LXP3
Secondary accession number(s): I3LV53
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 18, 2008
Last sequence update: March 18, 2008
Last modified: June 2, 2021
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
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