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Entry version 104 (22 Apr 2020)
Sequence version 2 (22 Feb 2012)
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Protein

Ryanodine receptor 2

Gene

Ryr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca2+ levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development (By similarity).By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Channel activity is modulated by the alkaloid ryanodine that binds to the open Ca-release channel with high affinity. At low concentrations, ryanodine maintains the channel in an open conformation. High ryanodine concentrations inhibit channel activity. Channel activity is regulated by calmodulin (CALM). The calcium release is activated by increased cytoplasmic calcium levels, by nitric oxyde (NO), caffeine and ATP. Channel activity is inhibited by magnesium ions, possibly by competition for calcium binding sites (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Calmodulin-binding, Developmental protein, Ion channel, Ligand-gated ion channel, Receptor
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-2672351 Stimuli-sensing channels
R-RNO-5578775 Ion homeostasis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ryanodine receptor 2
Short name:
RYR-2
Short name:
RyR2
Alternative name(s):
Cardiac muscle ryanodine receptor
Cardiac muscle ryanodine receptor-calcium release channel
Type 2 ryanodine receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ryr2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
620314 Ryr2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 4218CytoplasmicSequence analysisAdd BLAST4218
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4219 – 4239HelicalSequence analysisAdd BLAST21
Transmembranei4265 – 4285HelicalSequence analysisAdd BLAST21
Transmembranei4489 – 4509HelicalSequence analysisAdd BLAST21
Transmembranei4566 – 4586HelicalSequence analysisAdd BLAST21
Transmembranei4716 – 4736HelicalSequence analysisAdd BLAST21
Transmembranei4755 – 4775HelicalSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei4806 – 4815Pore-formingBy similarity10
Transmembranei4836 – 4856HelicalSequence analysisAdd BLAST21
Topological domaini4857 – 4953CytoplasmicSequence analysisAdd BLAST97

Keywords - Cellular componenti

Membrane, Sarcoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3388

DrugCentral

More...
DrugCentrali
B0LPN4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004155831 – 4953Ryanodine receptor 2Add BLAST4953

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1334PhosphoserineCombined sources1
Modified residuei1863PhosphoserineCombined sources1
Modified residuei2021PhosphoserineCombined sources1
Modified residuei2359PhosphoserineBy similarity1
Modified residuei2687PhosphoserineCombined sources1
Modified residuei2787PhosphoserineBy similarity1
Modified residuei2798Phosphoserine; by CaMK2D and PKACombined sources1 Publication1
Modified residuei2801PhosphoserineCombined sources1
Modified residuei2804Phosphoserine; by CaMK2DCombined sources1 Publication1
Modified residuei2937PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2798 and Ser-2804 increases the open probability of the calcium channel. Phosphorylation is increased in failing heart, leading to calcium leaks and increased cytoplasmic Ca2+ levels (By similarity).By similarity
Phosphorylation at Ser-2021 by PKA enhances the response to lumenal calcium.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B0LPN4

PeptideAtlas

More...
PeptideAtlasi
B0LPN4

PRoteomics IDEntifications database

More...
PRIDEi
B0LPN4

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
B0LPN4

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
B0LPN4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
B0LPN4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in heart muscle myocytes (at protein level). Widely expressed. Detected in heart muscle and cerebral artery smooth muscle. Detected in pancreatic islet cells.4 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer. Can also form heterotetramers with RYR3.

Identified in a complex composed of RYR2, FKBP1B, PKA catalytic subunit, PRKAR2A, AKAP6, and the protein phosphatases PP2A and PP1.

Interacts directly with FKBP1B, PKA, PP1 and PP2A (By similarity).

Interacts with FKBP1A and FKBP1B; these interactions may stabilize the channel in its closed state and prevent Ca2+ leaks.

Interacts with CALM and S100A1; these interactions regulate channel activity.

Interacts with SELENON (By similarity). In cardiac muscles, identified in a complex composed of FSD2, CMYA5 and RYR2 (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
604379, 3 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
B0LPN4

Protein interaction database and analysis system

More...
IntActi
B0LPN4, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000059019

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
B0LPN4

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

14953
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B0LPN4

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
B0LPN4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini103 – 158MIR 1PROSITE-ProRule annotationAdd BLAST56
Domaini165 – 210MIR 2PROSITE-ProRule annotationAdd BLAST46
Domaini218 – 273MIR 3PROSITE-ProRule annotationAdd BLAST56
Domaini279 – 336MIR 4PROSITE-ProRule annotationAdd BLAST58
Domaini344 – 401MIR 5PROSITE-ProRule annotationAdd BLAST58
Domaini592 – 802B30.2/SPRY 1PROSITE-ProRule annotationAdd BLAST211
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati846 – 9591Add BLAST114
Repeati960 – 10732Add BLAST114
Domaini1018 – 1215B30.2/SPRY 2PROSITE-ProRule annotationAdd BLAST198
Domaini1350 – 1556B30.2/SPRY 3PROSITE-ProRule annotationAdd BLAST207
Repeati2682 – 28003Add BLAST119
Repeati2802 – 29154Add BLAST114

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni846 – 29154 X approximate repeatsAdd BLAST2070
Regioni3559 – 3588Interaction with CALMBy similarityAdd BLAST30

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The calcium release channel activity resides in the C-terminal region while the remaining part of the protein resides in the cytoplasm.Curated

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2243 Eukaryota
ENOG410YCNW LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B0LPN4

KEGG Orthology (KO)

More...
KOi
K04962

Database of Orthologous Groups

More...
OrthoDBi
5161at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12877 SPRY1_RyR, 1 hit
cd12878 SPRY2_RyR, 1 hit
cd12879 SPRY3_RyR, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR014821 Ins145_P3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR013333 Ryan_recept
IPR003032 Ryanodine_rcpt
IPR009460 Ryanrecept_TM4-6
IPR035910 RyR/IP3R_RIH_dom_sf
IPR035761 SPRY1_RyR
IPR035764 SPRY2_RyR
IPR035762 SPRY3_RyR
IPR003877 SPRY_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF06459 RR_TM4-6, 1 hit
PF01365 RYDR_ITPR, 2 hits
PF02026 RyR, 4 hits
PF00622 SPRY, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00795 RYANODINER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00472 MIR, 4 hits
SM00449 SPRY, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100909 SSF100909, 2 hits
SSF47473 SSF47473, 1 hit
SSF49899 SSF49899, 2 hits
SSF82109 SSF82109, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188 B302_SPRY, 3 hits
PS50919 MIR, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: B0LPN4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADAGEGEDE IQFLRTDDEV VLQCTATIHK EQQKLCLAAE GFGNRLCFLE
60 70 80 90 100
STSNSKNVPP DLSICTFVLE QSLSVRALQE MLANTVEKSE GKFMMKTAQG
110 120 130 140 150
GGHRTLLYGH AILLRHSYSG MYLCCLSTSR SSTDKLAFDV GLQEDTTGEA
160 170 180 190 200
CWWTIHPASK QRSEGEKVRV GDDLILVSVS SERYLHLSYG NSSWRVDAAF
210 220 230 240 250
QQTLWSVAPI SSGSEAAQGY LIGGDVLRLL HGHMDECLTV PSGEHGEEQR
260 270 280 290 300
RTVHYEGGAV SVHARSLWRL ETLRVAWSGS HIRWGQPFRL RHVTTGKYLS
310 320 330 340 350
LMEDKNLLLM DKEKADVKST AFAFRSSKEK LDAGVRKEVD GMGTSEIKYG
360 370 380 390 400
DSICYIQHVD TGLWLTYQAV DVKSARMGSI QRKAIMHHEG HMDDGLNLSR
410 420 430 440 450
SQHEESRTAR VIRSTVFLFN RFIRGLDALS KRAKLPTVDL PIESVSLSLQ
460 470 480 490 500
DLIGYFHPPD EHLEHEDKQN RLRALKNRQN LFQEEGMINL VLECIDRLHV
510 520 530 540 550
YSSAAHFADV AGREAGESWK SILNSLYELL AALIRGNRKN CAQFSGSLDW
560 570 580 590 600
LISRLERLEA SSGILEVLHC VLVESPEALN IIKEGHIKSI ISLLDKHGRN
610 620 630 640 650
HKVLDVLCSL CVCHGVAVRS NQHLICDNLL PGRDLLLQTR LVNHVSSMRP
660 670 680 690 700
NIFLGVSEGS AQYKKWYYEL MVDHTEPFVT AEATHLRVGW ASTEGYSPYP
710 720 730 740 750
GGGEEWGGNG VGDDLFSYGF DGLHLWSGCI ARTVSSPNQH LLRTDDVISC
760 770 780 790 800
CLDLSAPSIS FRINGQPVQG MFENFNIDGL FFPVVSFSAG IKVRFLLGGR
810 820 830 840 850
HGEFKFLPPP GYAACYEAVL PKEKLKVEHS REYKQERTYT RDLLGPTVSL
860 870 880 890 900
TQAAFTPVPV DTSQIVLPPH LERIRERLAE NIHELWVMNK IELGWQYGPV
910 920 930 940 950
RDDNKRQHPC LVEFCKLPEQ ERNYNLQMSL ETLKTLLALG CHVGIADEHA
960 970 980 990 1000
EEKVKKMKLP KNYQLTSGYK PAPMDLSFIK LTPSQEAMVD KLAENAHNVW
1010 1020 1030 1040 1050
ARDRIRQGWT YGIQQDVKNR RNPRLVPYTL LDDRTKKSNK DSLREAVRTL
1060 1070 1080 1090 1100
LGYGYHLEAP DQDHASRAEV CSGTGERFRI FRAEKTYAVK AGRWYFEFEA
1110 1120 1130 1140 1150
VTAGDMRVGW SRPGCQPDLE LGSDERAFAF DGFKAQRWHQ GNEHYGRSWQ
1160 1170 1180 1190 1200
AGDVVGCMVD MNEHTMMFTL NGEILLDDSG SELAFKDFDV GDGFIPVCSL
1210 1220 1230 1240 1250
GVAQVGRMNF GKDVSTLKYF TICGLQEGYE PFAVNTNRDI TMWLSKRLPQ
1260 1270 1280 1290 1300
FLQVPSNHEH IEVTRIDGTI DSSPCLKVTQ KSFGSQNSNT DIMFYRLSMP
1310 1320 1330 1340 1350
IECAEVFSKS VAGGIPGAGF YGPKNDLEDF DVDSDFEVLM KTAHGHLVPD
1360 1370 1380 1390 1400
RMDKDKETPK PEFNNHKDYA QEKPSRLKQR FLLRRTKPDY STSHSARLTE
1410 1420 1430 1440 1450
DVLADDRDDY EYLMQTSTYY YSVRIFPGQE PANVWVGWIT SDFHQYDTGF
1460 1470 1480 1490 1500
DLDRVRTVTV TLGDEKGKVH ESIKRSNCYM VCAGESMSPG QGRNNSNGLE
1510 1520 1530 1540 1550
IGCVVDAASG LLTFIANGKE LSTYYQVEPS TKLFPAVFAQ ATSPNVFQFE
1560 1570 1580 1590 1600
LGRIKNVMPL SAGLFKSEHK NPVPQCPPRL HVQFLSHVLW SRMPNQFLKV
1610 1620 1630 1640 1650
DVSRISERQG WLVQCLDPLQ FMSLHIPEEN RSVDILELTE QEELLQFHYH
1660 1670 1680 1690 1700
TLRLYSAVCA LGNHRVAHAL CSHVDEPQLL YAIENKYMPG LLRAGYYDLL
1710 1720 1730 1740 1750
IDIHLSSYAT ARLMMNNEFI VPMTEETKSI TLFPDENKKH GLPGIGLSTS
1760 1770 1780 1790 1800
LRPRMCFSSP SFVSISNECY QYSPEFPLDI LKAKTIQMLT EAVKEGSLHA
1810 1820 1830 1840 1850
RDPVGGTTEF LFVPLIKLFY TLLIMGIFHN EDLKHILQLI EPSVFKEAAT
1860 1870 1880 1890 1900
PEEEGGAPEK EISIDDSKLE VKEEAKAGKR PKEGLLQMKL PEPVKLQMCL
1910 1920 1930 1940 1950
LLQYLCDCQV RHRIEAIVAF SDDFVAKLQD NQRFRYNEVM QALNMSAALT
1960 1970 1980 1990 2000
ARKEFRSPPQ EQINMLLNFK DDKSECPCPE EIRDQLLDFH EDLMTHCGIE
2010 2020 2030 2040 2050
LDEDGSLDGS NDLTIRGRLL SLVEKVTYLK KKQAEKPVAS DSRKSSSLQQ
2060 2070 2080 2090 2100
LISETMVRWA QESVIEDPEL VRAMFVLLHR QYDGIGGLVR ALPKTYTING
2110 2120 2130 2140 2150
VSVEDTINLL ASLGQIRSLL SVRMGKEEEK LMIRGLGDIM NNKVFYQHPN
2160 2170 2180 2190 2200
LMRALGMHET VMEVMVNVLG GGESKEITFP KMVANCCRFL CYFCRISRQN
2210 2220 2230 2240 2250
QKAMFDHLSY LLENSSVGLA SPAMRGSTPL DVAAASVMDN NELALALREP
2260 2270 2280 2290 2300
DLEKVVRYLA GCGLQSCQML VSKGYPDIGW NPVEGERYLD FLRFAVFCNG
2310 2320 2330 2340 2350
ESVEENANVV VRLLIRRPEC FGPALRGEGG NGLLAAMEEA IKIAEDPSRD
2360 2370 2380 2390 2400
GPSPTSGSSK TLDAEEEEDD TIHMGNAIMT FYAALIDLLG RCAPEMHLIH
2410 2420 2430 2440 2450
AGKGEAIRIR SILRSLIPLG DLVGVISIAF QMPTIAKDGK VVEPDMSAGF
2460 2470 2480 2490 2500
CPDHKAAMVL FLDRVYGIEV QDFLLHLLEV GFLPDLRAAA SLDTAALSAT
2510 2520 2530 2540 2550
DMALALNRYL CTAVLPLLTR CAPLFAGTEH HASLIDSLLH TVYRLSKGCS
2560 2570 2580 2590 2600
LTKAQRDSIE VCLLSICGQL RPSMMQHLLR RLVFDVPLLN EHAKMPLKLL
2610 2620 2630 2640 2650
TNHYERCWKY YCLPGGWSNF GAASEEELHL SRKLFWGIFD ALSQKKYEQE
2660 2670 2680 2690 2700
LFKLALPCLS AVAGALPPDY MESNYVSMME KQSSMDSEGN FNPQPVDTSN
2710 2720 2730 2740 2750
ITIPEKLEYF INKYAEHSHD KWSMDKLANG WIYGEIYSDS SKIQPLMKPY
2760 2770 2780 2790 2800
KLLSEKEKEI YRWPIKESLK TMLAWGWRIE RTREGDSMAL YNRTRRISQT
2810 2820 2830 2840 2850
SQVSIDAAHG YSPRAIDMSN VTLSRDLHAM AEMMAENYHN IWAKKKKMEL
2860 2870 2880 2890 2900
ESKGGGNHPL LVPYDTLTAK EKAKDREKAQ DIFKFLQISG YAVSRGFKDL
2910 2920 2930 2940 2950
DLDTPSIEKR FAYSFLQQLI RYVDEAHQYI LEFDGGSRSK GEHFPYEQEI
2960 2970 2980 2990 3000
KFFAKVVLPL IDQYFKNHRL YFLSAASRPL CTGGHASNKE KEMVTSLFCK
3010 3020 3030 3040 3050
LGVLVRHRIS LFGNDATSIV NCLHILGQTL DARTVMKTGL DSVKSALRAF
3060 3070 3080 3090 3100
LDNAAEDLEK TMENLKQGQF THTRSQPKGV TQIINYTTVA LLPMLSSLFE
3110 3120 3130 3140 3150
HIGQHQFGED LILEDVQVSC YRILTSLYAL GTSKSIYVER QRSALGECLA
3160 3170 3180 3190 3200
AFAGAFPIAF LETHLDKHNV YSIYNTRSSR ERAALSLPAN VEDVCPNIPS
3210 3220 3230 3240 3250
LEKLMTEIIE LAESGIRYTQ MPHMMEVVLP MLCSYMSRWW EHGPENHPER
3260 3270 3280 3290 3300
AEMCCTALNS EHMNTLLGNI LKIIYNNLGI DEGAWMKRLA VFSQPIINKV
3310 3320 3330 3340 3350
KPQLLKTHFL PLMEKLKKKA AMVVSEEDHL KAEARGDMSE AELLILDEFT
3360 3370 3380 3390 3400
TLARDLYAFY PLLIRFVDYN RAKWLKEPNP EAEELFRMVA EVFIYWSKSH
3410 3420 3430 3440 3450
NFKREEQNFV VQNEINNMSF LITDTKSKMS KAAISDQERK KMKRKGDRYS
3460 3470 3480 3490 3500
MQTSLIVAAL KRLLPIGLNI CAPGDQELIA LAKNRFSLKD TEEEVRDVIR
3510 3520 3530 3540 3550
SNIHLQGKLE DPAIRWQMAL YKDLPNRAED TSDPERTVER VLDIANVLFH
3560 3570 3580 3590 3600
LEQVEHPQRS KKAVWHKLLS KQRKRAVVAC FRMAPLYNLP RHRAVNLFLQ
3610 3620 3630 3640 3650
GYEKSWIETE EHYFEDKLIE DLAKPGSELP EEDEAMKRVD PLHQLILLFS
3660 3670 3680 3690 3700
RTALTEKCKL EEDFLYMAYA DIMAKSCHDE EDDDGEEEVK SFEVTGSQRS
3710 3720 3730 3740 3750
KEKEMEKQKL LYQQARLHDR GAAEMVLQTF SASKGETGPM VAATLKLGIA
3760 3770 3780 3790 3800
ILNGGNSTVQ QKMLDYLKEK KDVGFFQSLA GLMQSCSVLD LNAFERQNKA
3810 3820 3830 3840 3850
EGLGMVTEEG SGEKVLQDDE FTCDLFRFLQ LLCEGHNSDF QNYLRTQTGN
3860 3870 3880 3890 3900
NTTVNIIIST VDYLLRVQES ISDFYWYYSG KDIIDEQGQR NFSKAIQVAK
3910 3920 3930 3940 3950
QVFNTLTEYI QGPCTGNQQS LAHSRLWDAV VGFLHVFAHM QMKLSQDSSQ
3960 3970 3980 3990 4000
IELLKELMDL QKDMVVMLLS MLEGNVVNGT IGKQMVDMLV ESSNNVEMIL
4010 4020 4030 4040 4050
KFFDMFLKLK DLTSSDTFKE YDPDGKGVIS KRDFHKAMES HKHYTQSETE
4060 4070 4080 4090 4100
FLLSCAETDE NETLDYEEFV KRFHEPAKDI GFNVAVLLTN LSEHMPNDTR
4110 4120 4130 4140 4150
LQTFLELAES VLNYFQPFLG RIEIMGSAKR IERVYFEISE SSRTQWEKPQ
4160 4170 4180 4190 4200
VKESKRQFIF DVVNEGGEKE KMELFVNFCE DTIFEMQLAA QISESDLNER
4210 4220 4230 4240 4250
SANKEESEKE RPEEQAPRMG FFSLLTVQSA LFALRYNVLT LVRMLSLKSL
4260 4270 4280 4290 4300
KKQMKRMKKM TVKDMVSAFF SSYWSVFVTL LHFVASVCRG FFRIVSSLLL
4310 4320 4330 4340 4350
GGSLVEGAKK IKVAELLANM PDPTQDEVRG DEEEGERKPL ESALPSEDLT
4360 4370 4380 4390 4400
DLKELTEESD LLSDIFGLDL KREGGQYKLI PHNPNAGLSD LMTNPIPVPE
4410 4420 4430 4440 4450
VQEKFQEQKV KEEKEGKEET KSEPEKAEGE DGEKEEKAKD DKGKQKLRQL
4460 4470 4480 4490 4500
HTHRYGEPEV PESAFWKKII AYQQKLLNYF ARNFYNMRML ALFVAFAINF
4510 4520 4530 4540 4550
ILLFYKVSTS SVVEGKELPT RTSSDAAKVT TSLDSSPHRI IAVHYVLEES
4560 4570 4580 4590 4600
SGYMEPTLRI LAILHTIISF FCIIGYYCLK VPLVIFKREK EVARKLEFDG
4610 4620 4630 4640 4650
LYITEQPSED DIKGQWDRLV INTQSFPNNY WDKFVKRKVM DKYGEFYGRD
4660 4670 4680 4690 4700
RISELLGMDK AALDFSDARE KKKPKKDSSL SAVLNSIDVK YQMWKLGVVF
4710 4720 4730 4740 4750
TDNSFLYLAW YMTMSVLGHY NNFFFAAHLL DIAMGFKTLR TILSSVTHNG
4760 4770 4780 4790 4800
KQLVLTVGLL AVVVYLYTVV AFNFFRKFYN KSEDGDTPDM KCDDMLTCYM
4810 4820 4830 4840 4850
FHMYVGVRAG GGIGDEIEDP AGDEYEIYRI IFDITFFFFV IVILLAIIQG
4860 4870 4880 4890 4900
LIIDAFGELR DQQEQVKEDM ETKCFICGIG NDYFDTVPHG FETHTLQEHN
4910 4920 4930 4940 4950
LANYLFFLMY LINKDETEHT GQESYVWKMY QERCWEFFPA GDCFRKQYED

QLN
Length:4,953
Mass (Da):562,955
Last modified:February 22, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2C2798E8A2C4564A
GO
Isoform 2 (identifier: B0LPN4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1952-1952: R → RKT
     3694-3701: Missing.

Show »
Length:4,947
Mass (Da):562,340
Checksum:i2A7FC7A98D194D23
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1LS89F1LS89_RAT
Ryanodine receptor 2
Ryr2
4,938Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1LRZ1F1LRZ1_RAT
Ryanodine receptor 2
Ryr2
4,930Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti40E → G in ABY79796 (PubMed:20445169).Curated1
Sequence conflicti364W → R in ABY79796 (PubMed:20445169).Curated1
Sequence conflicti1838Q → R in ABY79796 (PubMed:20445169).Curated1
Sequence conflicti2691F → S in ABY79796 (PubMed:20445169).Curated1
Sequence conflicti3216I → T in ABY79796 (PubMed:20445169).Curated1
Sequence conflicti3226E → G in ABY79796 (PubMed:20445169).Curated1
Sequence conflicti3355D → N in ABY79796 (PubMed:20445169).Curated1
Sequence conflicti3541V → I in ABY79796 (PubMed:20445169).Curated1
Sequence conflicti3751I → T in ABY79796 (PubMed:20445169).Curated1
Sequence conflicti3885D → G in ABY79796 (PubMed:20445169).Curated1
Sequence conflicti3990V → A in ABY79796 (PubMed:20445169).Curated1
Sequence conflicti4196D → G in ABY79796 (PubMed:20445169).Curated1
Sequence conflicti4262V → A in ABY79796 (PubMed:20445169).Curated1
Sequence conflicti4536S → G in ABY79796 (PubMed:20445169).Curated1
Sequence conflicti4667D → G in ABY79796 (PubMed:20445169).Curated1
Sequence conflicti4930Y → H in ABY79796 (PubMed:20445169).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0422991952R → RKT in isoform 2. 1 Publication1
Alternative sequenceiVSP_0423003694 – 3701Missing in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EU346200 mRNA Translation: ABY79796.1
AB204523 mRNA Translation: BAJ10276.1

NCBI Reference Sequences

More...
RefSeqi
NP_001177972.1, NM_001191043.1
NP_114467.1, NM_032078.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
689560

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:689560

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU346200 mRNA Translation: ABY79796.1
AB204523 mRNA Translation: BAJ10276.1
RefSeqiNP_001177972.1, NM_001191043.1
NP_114467.1, NM_032078.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K2FNMR-C/D3561-3572[»]
SMRiB0LPN4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi604379, 3 interactors
CORUMiB0LPN4
IntActiB0LPN4, 1 interactor
STRINGi10116.ENSRNOP00000059019

Chemistry databases

BindingDBiB0LPN4
ChEMBLiCHEMBL3388
DrugCentraliB0LPN4

PTM databases

CarbonylDBiB0LPN4
iPTMnetiB0LPN4
PhosphoSitePlusiB0LPN4

Proteomic databases

PaxDbiB0LPN4
PeptideAtlasiB0LPN4
PRIDEiB0LPN4

Genome annotation databases

GeneIDi689560
KEGGirno:689560

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6262
RGDi620314 Ryr2

Phylogenomic databases

eggNOGiKOG2243 Eukaryota
ENOG410YCNW LUCA
InParanoidiB0LPN4
KOiK04962
OrthoDBi5161at2759

Enzyme and pathway databases

ReactomeiR-RNO-2672351 Stimuli-sensing channels
R-RNO-5578775 Ion homeostasis

Miscellaneous databases

EvolutionaryTraceiB0LPN4

Protein Ontology

More...
PROi
PR:B0LPN4

Family and domain databases

CDDicd12877 SPRY1_RyR, 1 hit
cd12878 SPRY2_RyR, 1 hit
cd12879 SPRY3_RyR, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR014821 Ins145_P3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR013333 Ryan_recept
IPR003032 Ryanodine_rcpt
IPR009460 Ryanrecept_TM4-6
IPR035910 RyR/IP3R_RIH_dom_sf
IPR035761 SPRY1_RyR
IPR035764 SPRY2_RyR
IPR035762 SPRY3_RyR
IPR003877 SPRY_dom
PfamiView protein in Pfam
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF06459 RR_TM4-6, 1 hit
PF01365 RYDR_ITPR, 2 hits
PF02026 RyR, 4 hits
PF00622 SPRY, 3 hits
PRINTSiPR00795 RYANODINER
SMARTiView protein in SMART
SM00472 MIR, 4 hits
SM00449 SPRY, 3 hits
SUPFAMiSSF100909 SSF100909, 2 hits
SSF47473 SSF47473, 1 hit
SSF49899 SSF49899, 2 hits
SSF82109 SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 3 hits
PS50919 MIR, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRYR2_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B0LPN4
Secondary accession number(s): D7UNT3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: February 22, 2012
Last modified: April 22, 2020
This is version 104 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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