AKT1

Functionⁱ

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
GTPase activating protein binding Source: Ensembl
protein kinase C binding Source: Ensembl
protein phosphatase 2A binding Source: Ensembl
protein serine/threonine kinase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

aging Source: Ensembl
apoptotic mitochondrial changes Source: Ensembl
cell projection organization Source: Ensembl
cellular response to DNA damage stimulus Source: Ensembl
cellular response to epidermal growth factor stimulus Source: Ensembl
cellular response to granulocyte macrophage colony-stimulating factor stimulus Source: Ensembl
cellular response to hypoxia Source: Ensembl
cellular response to mechanical stimulus Source: Ensembl
cellular response to nerve growth factor stimulus Source: Ensembl
cellular response to organic cyclic compound Source: Ensembl
cellular response to prostaglandin E stimulus Source: Ensembl
cellular response to tumor necrosis factor Source: Ensembl
cellular response to vascular endothelial growth factor stimulus Source: Ensembl
execution phase of apoptosis Source: Ensembl
germ cell development Source: Ensembl
glucose homeostasis Source: Ensembl
glucose metabolic process Source: Ensembl
glycogen biosynthetic process Source: Ensembl
glycogen cell differentiation involved in embryonic placenta development Source: Ensembl
hyaluronan metabolic process Source: Ensembl
inflammatory response Source: Ensembl
insulin receptor signaling pathway Source: Ensembl
labyrinthine layer blood vessel development Source: Ensembl
lipopolysaccharide-mediated signaling pathway Source: Ensembl
maternal placenta development Source: Ensembl
negative regulation of cell size Source: Ensembl
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
negative regulation of gene expression Source: Ensembl
negative regulation of JNK cascade Source: Ensembl
negative regulation of protein kinase activity Source: Ensembl
negative regulation of release of cytochrome c from mitochondria Source: Ensembl
osteoblast differentiation Source: Ensembl
peptidyl-serine phosphorylation Source: Ensembl
peripheral nervous system myelin maintenance Source: Ensembl
positive regulation of apoptotic process Source: Ensembl
positive regulation of cell growth Source: Ensembl
positive regulation of fibroblast migration Source: Ensembl
positive regulation of organ growth Source: Ensembl
positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
positive regulation of protein localization to cell surface Source: Ensembl
positive regulation of sodium ion transport Source: Ensembl
positive regulation of transcription by RNA polymerase II Source: Ensembl
positive regulation of vasoconstriction Source: Ensembl
protein catabolic process Source: Ensembl
protein kinase B signaling Source: Ensembl
protein ubiquitination Source: Ensembl
regulation of myelination Source: Ensembl
regulation of neuron projection development Source: Ensembl
response to food Source: Ensembl
response to growth hormone Source: AgBase
response to insulin-like growth factor stimulus Source: AgBase
spinal cord development Source: Ensembl
striated muscle cell differentiation Source: Ensembl
translation Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase
Ligand	ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Non-specific serine/threonine protein kinaseSAAS annotation (EC:2.7.11.1SAAS annotation)
Gene namesⁱ	Name:AKT1Imported ORF Names:hCG_96740Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000142208.15

EuPathDBⁱ

HostDB:ENSG00000142208.15

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA24684

PharmGKBⁱ

PA24684

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000142208 Expressed in 215 organ(s), highest expression level in left adrenal gland

Bgeeⁱ

ENSG00000142208 Expressed in 215 organ(s), highest expression level in left adrenal gland

Interactionⁱ

GO - Molecular functionⁱ

GTPase activating protein binding Source: Ensembl
protein kinase C binding Source: Ensembl
protein phosphatase 2A binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	B0LPE5, 1 interactor

IntActⁱ

B0LPE5, 1 interactor

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	5 – 108	PHInterPro annotationAdd BLAST	104
Domainⁱ	150 – 408	Protein kinaseInterPro annotationAdd BLAST	259
Domainⁱ	409 – 480	AGC-kinase C-terminalInterPro annotationAdd BLAST	72

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG0598 Eukaryota ENOG410XNPH LUCA
HOVERGENⁱ	HBG108317
KEGG Orthology (KO) More...KOⁱ	K04456
OMAⁱ	QHRFFAS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06FF

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01241 PH_PKB, 1 hit cd05594 STKc_PKB_alpha, 1 hit
Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR000961 AGC-kinase_C IPR034676 Akt1 IPR011009 Kinase-like_dom_sf IPR011993 PH-like_dom_sf IPR001849 PH_domain IPR039026 PH_PKB IPR017892 Pkinase_C IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR039027 RAC_alpha/beta IPR008271 Ser/Thr_kinase_AS
PANTHERⁱ	PTHR24356:SF176 PTHR24356:SF176, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00169 PH, 1 hit PF00069 Pkinase, 1 hit PF00433 Pkinase_C, 1 hit
SMARTⁱ	View protein in SMART SM00233 PH, 1 hit SM00133 S_TK_X, 1 hit SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51285 AGC_KINASE_CTER, 1 hit PS50003 PH_DOMAIN, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

B0LPE5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSDVAIVKEG WLHKRGEYIK TWRPRYFLLK NDGTFIGYKE RPQDVDQREA 
        60         70         80         90        100
PLNNFSVAQC QLMKTERPRP NTFIIRCLQW TTVIERTFHV ETPEEREEWT 
       110        120        130        140        150
TAIQTVADGL KKQEEEEMDF RSGSPSDNSG AEEMEVSLAK PKHRVTMNEF 
       160        170        180        190        200
EYLKLLGKGT FGKVILVKEK ATGRYYAMKI LKKEVIVAKD EVAHTLTENR 
       210        220        230        240        250
VLQNSRHPFL TALKYSFQTH DRLCFVMEYA NGGELFFHLS RERVFSEDRA 
       260        270        280        290        300
RFYGAEIVSA LDYLHSEKNV VYRDLKLENL MLDKDGHIKI TDFGLCKEGI 
       310        320        330        340        350
KDGATMKTFC GTPEYLAPEV LEDNDYGRAV DWWGLGVVMY EMMCGRLPFY 
       360        370        380        390        400
NQDHEKLFEL ILMEEIRFPR TLGPEAKSLL SGLLKKDPKQ RLGGGSEDAK 
       410        420        430        440        450
EIMQHRFFAG IVWQHVYEKK LSPPFKPQVT SETDTRYFDE EFTAQMITIT 
       460        470        480
PPDQDDSMEC VDSERRPHFP QFSYSASGTA

Length:480

Mass (Da):55,686

Last modified:March 18, 2008 - v1

Checksum:ⁱ6EAFF4F8AD436714

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	480	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EU332835 Genomic DNA Translation: ABY87524.1 JX512440 Genomic DNA Translation: AGC09587.1 KU177898 mRNA Translation: ALQ33356.1 CH471061 Genomic DNA Translation: EAW81881.1 CH471061 Genomic DNA Translation: EAW81882.1 CH471061 Genomic DNA Translation: EAW81883.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001014431.1, NM_001014431.1 NP_001014432.1, NM_001014432.1 NP_005154.2, NM_005163.2 XP_005267458.1, XM_005267401.1
UniGeneⁱ	Hs.525622

Genome annotation databases

GeneIDⁱ	207
KEGGⁱ	hsa:207

Protein	Similar proteins		Species	Score	Length	Source
B0LPE5	RAC-alpha serine/threonine-protein kinase	)	HUMAN		480	UniRef100_P31749
Non-specific serine/threonine protein kinase		PANTR		480
Non-specific serine/threonine protein kinase		PONAB		480
Non-specific serine/threonine protein kinase		PANPA		480
Non-specific serine/threonine protein kinase		NOMLE		480
+4

Protein	Similar proteins		Species	Score	Length	Source
B0LPE5	RAC-alpha serine/threonine-protein kinase	)	HUMAN		480	UniRef90_P31749
RAC-alpha serine/threonine-protein kinase		XENLA		481
RAC-alpha serine/threonine-protein kinase		BOVIN		480
RAC-alpha serine/threonine-protein kinase		RAT		480
Non-specific serine/threonine protein kinase		PANTR		480
+219

Protein	Similar proteins		Species	Score	Length	Source
B0LPE5	RAC-alpha serine/threonine-protein kinase	)	HUMAN		480	UniRef50_P31749
RAC-alpha serine/threonine-protein kinase		XENLA		481
RAC-alpha serine/threonine-protein kinase		RAT		480
RAC-alpha serine/threonine-protein kinase		BOVIN		480
RAC-alpha serine/threonine-protein kinase		MOUSE		480
+276

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EU332835 Genomic DNA Translation: ABY87524.1 JX512440 Genomic DNA Translation: AGC09587.1 KU177898 mRNA Translation: ALQ33356.1 CH471061 Genomic DNA Translation: EAW81881.1 CH471061 Genomic DNA Translation: EAW81882.1 CH471061 Genomic DNA Translation: EAW81883.1
RefSeqⁱ	NP_001014431.1, NM_001014431.1 NP_001014432.1, NM_001014432.1 NP_005154.2, NM_005163.2 XP_005267458.1, XM_005267401.1
UniGeneⁱ	Hs.525622

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	B0LPE5, 1 interactor

IntActⁱ

B0LPE5, 1 interactor

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	207
Structural Biology Knowledgebase	Search...

Genome annotation databases

GeneIDⁱ	207
KEGGⁱ	hsa:207

Organism-specific databases

CTDⁱ	207
EuPathDBⁱ	HostDB:ENSG00000142208.15
PharmGKBⁱ	PA24684

Phylogenomic databases

eggNOGⁱ	KOG0598 Eukaryota ENOG410XNPH LUCA
HOVERGENⁱ	HBG108317
KOⁱ	K04456
OMAⁱ	QHRFFAS
OrthoDBⁱ	EOG091G06FF

Miscellaneous databases

ChiTaRSⁱ	AKT1 human
GenomeRNAiⁱ	207

Gene expression databases

Bgeeⁱ	ENSG00000142208 Expressed in 215 organ(s), highest expression level in left adrenal gland

Bgeeⁱ

ENSG00000142208 Expressed in 215 organ(s), highest expression level in left adrenal gland

Family and domain databases

CDDⁱ	cd01241 PH_PKB, 1 hit cd05594 STKc_PKB_alpha, 1 hit
Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR000961 AGC-kinase_C IPR034676 Akt1 IPR011009 Kinase-like_dom_sf IPR011993 PH-like_dom_sf IPR001849 PH_domain IPR039026 PH_PKB IPR017892 Pkinase_C IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR039027 RAC_alpha/beta IPR008271 Ser/Thr_kinase_AS
PANTHERⁱ	PTHR24356:SF176 PTHR24356:SF176, 1 hit
Pfamⁱ	View protein in Pfam PF00169 PH, 1 hit PF00069 Pkinase, 1 hit PF00433 Pkinase_C, 1 hit
SMARTⁱ	View protein in SMART SM00233 PH, 1 hit SM00133 S_TK_X, 1 hit SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51285 AGC_KINASE_CTER, 1 hit PS50003 PH_DOMAIN, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B0LPE5_HUMAN
Accessionⁱ	B0LPE5Primary (citable) accession number: B0LPE5
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	March 18, 2008
	Last sequence update:	March 18, 2008
	Last modified:	October 10, 2018
	This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - B0LPE5 (B0LPE5_HUMAN)

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Non-specific serine/threonine protein kinase

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytosol

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Plasma Membrane

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<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

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Miscellaneous databases

Gene expression databases

Family and domain databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ