UniProtKB - B0LPE5 (B0LPE5_HUMAN)
Protein
RAC-PK-alpha
Gene
AKT1
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 189 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- GTPase activating protein binding Source: Ensembl
- protein kinase C binding Source: Ensembl
- protein phosphatase 2A binding Source: Ensembl
- protein serine kinase activity Source: UniProtKB-EC
- protein threonine kinase activity Source: UniProtKB-EC
GO - Biological processi
- aging Source: Ensembl
- apoptotic mitochondrial changes Source: Ensembl
- cell projection organization Source: Ensembl
- cellular response to DNA damage stimulus Source: Ensembl
- cellular response to epidermal growth factor stimulus Source: Ensembl
- cellular response to granulocyte macrophage colony-stimulating factor stimulus Source: Ensembl
- cellular response to hypoxia Source: Ensembl
- cellular response to mechanical stimulus Source: Ensembl
- cellular response to nerve growth factor stimulus Source: Ensembl
- cellular response to organic cyclic compound Source: Ensembl
- cellular response to prostaglandin E stimulus Source: Ensembl
- cellular response to tumor necrosis factor Source: Ensembl
- cellular response to vascular endothelial growth factor stimulus Source: Ensembl
- execution phase of apoptosis Source: Ensembl
- germ cell development Source: Ensembl
- glucose homeostasis Source: Ensembl
- glucose metabolic process Source: UniProtKB-KW
- glycogen biosynthetic process Source: UniProtKB-KW
- glycogen cell differentiation involved in embryonic placenta development Source: Ensembl
- hyaluronan metabolic process Source: Ensembl
- inflammatory response Source: Ensembl
- insulin receptor signaling pathway Source: Ensembl
- labyrinthine layer blood vessel development Source: Ensembl
- lipopolysaccharide-mediated signaling pathway Source: Ensembl
- maternal placenta development Source: Ensembl
- negative regulation of cell size Source: Ensembl
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
- negative regulation of gene expression Source: Ensembl
- negative regulation of intrinsic apoptotic signaling pathway Source: Ensembl
- negative regulation of JNK cascade Source: Ensembl
- negative regulation of protein kinase activity Source: Ensembl
- negative regulation of release of cytochrome c from mitochondria Source: Ensembl
- osteoblast differentiation Source: Ensembl
- peptidyl-serine phosphorylation Source: Ensembl
- peripheral nervous system myelin maintenance Source: Ensembl
- positive regulation of apoptotic process Source: Ensembl
- positive regulation of cell growth Source: Ensembl
- positive regulation of fibroblast migration Source: Ensembl
- positive regulation of organ growth Source: Ensembl
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
- positive regulation of protein localization to cell surface Source: Ensembl
- positive regulation of sodium ion transport Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- positive regulation of vasoconstriction Source: Ensembl
- protein catabolic process Source: Ensembl
- protein kinase B signaling Source: Ensembl
- protein ubiquitination Source: Ensembl
- regulation of myelination Source: Ensembl
- regulation of neuron projection development Source: Ensembl
- response to food Source: Ensembl
- response to growth hormone Source: AgBase
- response to insulin-like growth factor stimulus Source: AgBase
- spinal cord development Source: Ensembl
- striated muscle cell differentiation Source: Ensembl
- translation Source: Ensembl
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseUniRule annotationARBA annotation, Transferase |
Biological process | Carbohydrate metabolism, Glucose metabolismARBA annotation, Glycogen biosynthesisARBA annotation |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: RAC-PK-alphaARBA annotation (EC:2.7.11.1ARBA annotation)Alternative name(s): RAC-alpha serine/threonine-protein kinaseARBA annotation |
Gene namesi | Name:AKT1Imported ORF Names:hCG_96740Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000142208.15 |
Subcellular locationi
Cytoskeleton
- ciliary basal body Source: Ensembl
- microtubule cytoskeleton Source: HPA
- spindle Source: Ensembl
Cytosol
- cytosol Source: Ensembl
Mitochondrion
- mitochondrion Source: Ensembl
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- plasma membrane Source: Ensembl
Other locations
- cell-cell junction Source: Ensembl
- protein-containing complex Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSG00000142208, Expressed in left adrenal gland and 232 other tissues |
ExpressionAtlasi | B0LPE5, baseline and differential |
Interactioni
Binary interactionsi
B0LPE5
With | #Exp. | IntAct |
---|---|---|
TCL1A [P56279] | 3 | EBI-10175397,EBI-749995 |
GO - Molecular functioni
- GTPase activating protein binding Source: Ensembl
- protein kinase C binding Source: Ensembl
- protein phosphatase 2A binding Source: Ensembl
Protein-protein interaction databases
IntActi | B0LPE5, 1 interactor |
Chemistry databases
BindingDBi | B0LPE5 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 108 | PHInterPro annotationAdd BLAST | 104 | |
Domaini | 150 – 408 | Protein kinaseInterPro annotationAdd BLAST | 259 | |
Domaini | 409 – 480 | AGC-kinase C-terminalInterPro annotationAdd BLAST | 72 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 113 – 138 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 450 – 480 | DisorderedSequence analysisAdd BLAST | 31 |
Sequence similaritiesi
Belongs to the protein kinase superfamily.UniRule annotation
Phylogenomic databases
OMAi | KFFAGIN |
OrthoDBi | 614710at2759 |
Family and domain databases
CDDi | cd01241, PH_PKB, 1 hit cd05594, STKc_PKB_alpha, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR034676, Akt1 IPR011009, Kinase-like_dom_sf IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR039026, PH_PKB IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR039027, RAC_alpha IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR24351:SF200, PTHR24351:SF200, 1 hit |
Pfami | View protein in Pfam PF00169, PH, 1 hit PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS50003, PH_DOMAIN, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
B0LPE5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDVAIVKEG WLHKRGEYIK TWRPRYFLLK NDGTFIGYKE RPQDVDQREA
60 70 80 90 100
PLNNFSVAQC QLMKTERPRP NTFIIRCLQW TTVIERTFHV ETPEEREEWT
110 120 130 140 150
TAIQTVADGL KKQEEEEMDF RSGSPSDNSG AEEMEVSLAK PKHRVTMNEF
160 170 180 190 200
EYLKLLGKGT FGKVILVKEK ATGRYYAMKI LKKEVIVAKD EVAHTLTENR
210 220 230 240 250
VLQNSRHPFL TALKYSFQTH DRLCFVMEYA NGGELFFHLS RERVFSEDRA
260 270 280 290 300
RFYGAEIVSA LDYLHSEKNV VYRDLKLENL MLDKDGHIKI TDFGLCKEGI
310 320 330 340 350
KDGATMKTFC GTPEYLAPEV LEDNDYGRAV DWWGLGVVMY EMMCGRLPFY
360 370 380 390 400
NQDHEKLFEL ILMEEIRFPR TLGPEAKSLL SGLLKKDPKQ RLGGGSEDAK
410 420 430 440 450
EIMQHRFFAG IVWQHVYEKK LSPPFKPQVT SETDTRYFDE EFTAQMITIT
460 470 480
PPDQDDSMEC VDSERRPHFP QFSYSASGTA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU332835 Genomic DNA Translation: ABY87524.1 JX512440 Genomic DNA Translation: AGC09587.1 KU177898 mRNA Translation: ALQ33356.1 CH471061 Genomic DNA Translation: EAW81881.1 CH471061 Genomic DNA Translation: EAW81882.1 CH471061 Genomic DNA Translation: EAW81883.1 |
RefSeqi | NP_001014431.1, NM_001014431.1 NP_001014432.1, NM_001014432.1 NP_005154.2, NM_005163.2 XP_005267458.1, XM_005267401.1 |
Genome annotation databases
GeneIDi | 207 |
KEGGi | hsa:207 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU332835 Genomic DNA Translation: ABY87524.1 JX512440 Genomic DNA Translation: AGC09587.1 KU177898 mRNA Translation: ALQ33356.1 CH471061 Genomic DNA Translation: EAW81881.1 CH471061 Genomic DNA Translation: EAW81882.1 CH471061 Genomic DNA Translation: EAW81883.1 |
RefSeqi | NP_001014431.1, NM_001014431.1 NP_001014432.1, NM_001014432.1 NP_005154.2, NM_005163.2 XP_005267458.1, XM_005267401.1 |
3D structure databases
SMRi | B0LPE5 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | B0LPE5, 1 interactor |
Chemistry databases
BindingDBi | B0LPE5 |
Protocols and materials databases
Antibodypediai | 135, 5127 antibodies |
DNASUi | 207 |
Genome annotation databases
GeneIDi | 207 |
KEGGi | hsa:207 |
Organism-specific databases
CTDi | 207 |
PharmGKBi | PA24684 |
VEuPathDBi | HostDB:ENSG00000142208.15 |
Phylogenomic databases
OMAi | KFFAGIN |
OrthoDBi | 614710at2759 |
Miscellaneous databases
BioGRID-ORCSi | 207, 45 hits in 1031 CRISPR screens |
ChiTaRSi | AKT1, human |
GenomeRNAii | 207 |
Gene expression databases
Bgeei | ENSG00000142208, Expressed in left adrenal gland and 232 other tissues |
ExpressionAtlasi | B0LPE5, baseline and differential |
Family and domain databases
CDDi | cd01241, PH_PKB, 1 hit cd05594, STKc_PKB_alpha, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR034676, Akt1 IPR011009, Kinase-like_dom_sf IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR039026, PH_PKB IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR039027, RAC_alpha IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR24351:SF200, PTHR24351:SF200, 1 hit |
Pfami | View protein in Pfam PF00169, PH, 1 hit PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS50003, PH_DOMAIN, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B0LPE5_HUMAN | |
Accessioni | B0LPE5Primary (citable) accession number: B0LPE5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 18, 2008 |
Last sequence update: | March 18, 2008 | |
Last modified: | April 7, 2021 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |