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Protein

Septin-8

Gene

SEPT8

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity).By similarityCurated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei106GTP; via amide nitrogenBy similarity1
Binding sitei241GTP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei256GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi51 – 58GTPBy similarity8
Nucleotide bindingi187 – 195GTPBy similarity9

GO - Molecular functioni

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-8
Gene namesi
Name:SEPT8
OrganismiCallithrix jacchus (White-tufted-ear marmoset)
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrixCallithrix
Proteomesi
  • UP000008225 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003632252 – 442Septin-8Add BLAST441

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei10PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiB0KWP7

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with CDK14, SEPT4, SEPT5 and SEPT7 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9483.ENSCJAP00000027173

Structurei

3D structure databases

ProteinModelPortaliB0KWP7
SMRiB0KWP7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 307Septin-type GPROSITE-ProRule annotationAdd BLAST267

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 58G1 motifPROSITE-ProRule annotation8
Regioni103 – 106G3 motifPROSITE-ProRule annotation4
Regioni186 – 189G4 motifPROSITE-ProRule annotation4

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili322 – 410Sequence analysisAdd BLAST89

Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2655 Eukaryota
COG5019 LUCA
HOGENOMiHOG000233586
HOVERGENiHBG065093
InParanoidiB0KWP7

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR030646 SEPT8
IPR016491 Septin
PANTHERiPTHR18884:SF54 PTHR18884:SF54, 1 hit
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B0KWP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATDLERFS NAEAEPRSLS LGGHVGFDSL PDQLVSKSVT QGFSFNILCV
60 70 80 90 100
GETGIGKSTL MNTLFNTTFE TEEASHHEAC VRLRPQTYDL QESNVQLKLT
110 120 130 140 150
IVDAVGFGDQ INKDESYRPI VDYIDAQFEN YLQEELKIRR SLFDYHDTRI
160 170 180 190 200
HVCLYFITPT GHSLKSLDLV TMKKLDSKVN IIPIIAKADT ISKSELHKFK
210 220 230 240 250
IKIMGELVSN GVQIYQFPTD DEAVAEINAV MNAHLPFAVV GSTEEVKVGN
260 270 280 290 300
KLVRARQYPW GVVQVENENH CDFVKLREML IRVNMEDLRE QTHSRHYELY
310 320 330 340 350
RRCKLEEMGF QDSDGDSQPF SLQETYEAKR KEFLSELQRK EEEMRQMFVN
360 370 380 390 400
KVKETELELK EKERELHEKF EHLKRVHQEE KRKVEEKRRE LEEETNAFNR
410 420 430 440
RKAAVEALQS QALHATSQQP LRKDKDKKKA SGWSSIYSVT IP
Length:442
Mass (Da):51,152
Last modified:March 18, 2008 - v1
Checksum:iBB23DEA3FE1019F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000584 Genomic DNA Translation: ABZ10527.1

Similar proteinsi

Entry informationi

Entry nameiSEPT8_CALJA
AccessioniPrimary (citable) accession number: B0KWP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: March 18, 2008
Last modified: June 20, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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