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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Pseudomonas putida (strain GB-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei63SubstrateUniRule annotation1
Binding sitei139SubstrateUniRule annotation1
Binding sitei164SubstrateUniRule annotation1
Binding sitei194SubstrateUniRule annotation1
Binding sitei198SubstrateUniRule annotation1
Binding sitei199NADUniRule annotation1
Binding sitei251NADUniRule annotation1
Binding sitei300NADUniRule annotation1
Binding sitei375NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi165 – 167NADUniRule annotation3
Nucleotide bindingi228 – 233NADUniRule annotation6
Nucleotide bindingi321 – 323NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

BioCyciPPUT76869:G1GAZ-5166-MONOMER
UniPathwayiUPA00314; UER00076

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Ordered Locus Names:PputGB1_5025
OrganismiPseudomonas putida (strain GB-1)
Taxonomic identifieri76869 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002157 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000822801 – 469AdenosylhomocysteinaseAdd BLAST469

Proteomic databases

PRIDEiB0KM00

Interactioni

Protein-protein interaction databases

STRINGi76869.PputGB1_5025

Structurei

3D structure databases

ProteinModelPortaliB0KM00
SMRiB0KM00
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3E Bacteria
COG0499 LUCA
HOGENOMiHOG000227986
KOiK01251
OMAiTGNRDII

Family and domain databases

CDDicd00401 SAHH, 1 hit
HAMAPiMF_00563 AdoHcyase, 1 hit
InterProiView protein in InterPro
IPR034373 Adenosylhomocysteinase
IPR000043 Adenosylhomocysteinase-like
IPR015878 Ado_hCys_hydrolase_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020082 S-Ado-L-homoCys_hydrolase_CS
PANTHERiPTHR23420 PTHR23420, 1 hit
PfamiView protein in Pfam
PF05221 AdoHcyase, 1 hit
PF00670 AdoHcyase_NAD, 1 hit
PIRSFiPIRSF001109 Ad_hcy_hydrolase, 1 hit
SMARTiView protein in SMART
SM00996 AdoHcyase, 1 hit
SM00997 AdoHcyase_NAD, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00936 ahcY, 1 hit
PROSITEiView protein in PROSITE
PS00738 ADOHCYASE_1, 1 hit
PS00739 ADOHCYASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

B0KM00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAANMPAGF TDYKVADISL AAWGRRETII AESEMPALMG LRRKYLTEQP
60 70 80 90 100
LKGAKILGCI HMTIQTAVLI ETLVALGAEV RWSSCNIFST QDQAAASIAA
110 120 130 140 150
AGIPVFAWKG ETEEEYEWCL EQTILKDGQP WDANMILDDG GDLTELLHKK
160 170 180 190 200
YPQVLDRVHG VTEETTTGVH RLLDMLAKGE LKVPAINVND SVTKSKNDNK
210 220 230 240 250
YGCRHSLNDA IKRGTDHLLS GKQALVIGYG DVGKGSAQSL RQEGMIVKVT
260 270 280 290 300
EVDPICAMQA CMDGFELVSP FIDGINDGTE ASIDKALLGK IDLIVTTTGN
310 320 330 340 350
VNVCDANMLK ALKKRAVVCN IGHFDNEIDT AFMRKNWAWE EVKPQVHKIH
360 370 380 390 400
RTGAGSFDPQ NDDYLILLAE GRLVNLGNAT GHPSRIMDGS FANQVLAQIF
410 420 430 440 450
LFEQKYADLS AEKKAERLTV EVLPKKLDEE VALEMVRGFG GVVTKLTKQQ
460
ADYIGVTVEG PFKPHAYRY
Length:469
Mass (Da):51,511
Last modified:March 18, 2008 - v1
Checksum:iFB3A7B5971BA49C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000926 Genomic DNA Translation: ABZ00910.1
RefSeqiWP_012274535.1, NC_010322.1

Genome annotation databases

EnsemblBacteriaiABZ00910; ABZ00910; PputGB1_5025
KEGGippg:PputGB1_5025

Similar proteinsi

Entry informationi

Entry nameiSAHH_PSEPG
AccessioniPrimary (citable) accession number: B0KM00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 18, 2008
Last modified: February 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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