Osr1

Functionⁱ

Transcription factor that plays a role in the regulation of embryonic heart and urogenital development.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	175 – 197	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	203 – 225	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	231 – 253	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
protein kinase binding Source: Ensembl
protein serine/threonine kinase activity Source: Ensembl
RNA polymerase II regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell proliferation involved in kidney development Source: UniProtKB
cellular response to retinoic acid Source: Ensembl
chondrocyte differentiation Source: Ensembl
embryonic digit morphogenesis Source: Ensembl
embryonic forelimb morphogenesis Source: Ensembl
embryonic hindlimb morphogenesis Source: Ensembl
embryonic skeletal limb joint morphogenesis Source: Ensembl
gonad development Source: Ensembl
heart development Source: UniProtKB
intermediate mesoderm development Source: Ensembl
mesangial cell development Source: UniProtKB
mesonephric duct morphogenesis Source: UniProtKB
mesonephros development Source: UniProtKB
metanephric cap mesenchymal cell proliferation involved in metanephros development Source: UniProtKB
metanephric epithelium development Source: UniProtKB
metanephric glomerulus vasculature development Source: UniProtKB
metanephric interstitial fibroblast development Source: UniProtKB
metanephric mesenchymal cell differentiation Source: UniProtKB
metanephric mesenchyme development Source: UniProtKB
metanephric mesenchyme morphogenesis Source: UniProtKB
metanephric nephron tubule development Source: UniProtKB
metanephric smooth muscle tissue development Source: UniProtKB
middle ear morphogenesis Source: UniProtKB
negative regulation of apoptotic process Source: UniProtKB
negative regulation of creatine transmembrane transporter activity Source: Ensembl
negative regulation of epithelial cell differentiation Source: UniProtKB
negative regulation of nephron tubule epithelial cell differentiation Source: UniProtKB
negative regulation of sodium ion transmembrane transporter activity Source: Ensembl
negative regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
odontogenesis Source: UniProtKB
osmosensory signaling pathway Source: Ensembl
pattern specification involved in metanephros development Source: UniProtKB
peptidyl-threonine phosphorylation Source: Ensembl
positive regulation of bone mineralization Source: Ensembl
positive regulation of epithelial cell proliferation Source: UniProtKB
positive regulation of gastrulation Source: UniProtKB
positive regulation of gene expression Source: UniProtKB
positive regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
posterior mesonephric tubule development Source: UniProtKB
pronephros development Source: UniProtKB
renal vesicle progenitor cell differentiation Source: UniProtKB
roof of mouth development Source: UniProtKB
signal transduction by trans-phosphorylation Source: Ensembl
specification of anterior mesonephric tubule identity Source: UniProtKB
specification of posterior mesonephric tubule identity Source: UniProtKB
stem cell differentiation Source: UniProtKB
ureteric bud development Source: UniProtKB
ureter urothelium development Source: UniProtKB
urogenital system development Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein odd-skipped-related 1
Gene namesⁱ	Name:Osr1 Synonyms:Odd1
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 6

Organism-specific databases

Rat genome database More...RGDⁱ	1311807 Osr1

RGDⁱ

1311807 Osr1

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000402805	1 – 266	Protein odd-skipped-related 1Add BLAST		266

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	116	Asymmetric dimethylarginineBy similarity		1

Keywords - PTMⁱ

Methylation

Proteomic databases

PaxDbⁱ	B0K011
PRIDEⁱ	B0K011

PTM databases

PhosphoSitePlusⁱ	B0K011

PhosphoSitePlusⁱ

B0K011

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000004210 Expressed in 8 organ(s), highest expression level in skeletal muscle tissue

Bgeeⁱ

ENSRNOG00000004210 Expressed in 8 organ(s), highest expression level in skeletal muscle tissue

Interactionⁱ

GO - Molecular functionⁱ

protein kinase binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000005666

STRINGⁱ

10116.ENSRNOP00000005666

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B0K011
SMRⁱ	B0K011
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the Odd C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	175 – 197	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	203 – 225	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	231 – 253	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000137939
HOGENOMⁱ	HOG000013107
HOVERGENⁱ	HBG054398
InParanoidⁱ	B0K011
KEGG Orthology (KO) More...KOⁱ	K09215
OMAⁱ	GPALKTK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0LRE
PhylomeDBⁱ	B0K011
TreeFamⁱ	TF350876

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

B0K011-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGSKTLPAPV PIHPSLQLTN YSFLQAVNGL PTVPSDHLPN LYGFSALHAV 
        60         70         80         90        100
HLHQWTLGYP AMHLPRSSFS KVPGAVSSLM DARFQLPAFP WFPHVIHPKP 
       110        120        130        140        150
EITAGGSGAA LKTKPRFDFA NLALAATQED PTKLGRGEGP GSPAGGLGAL 
       160        170        180        190        200
LDVTKLSPEK KPTRGRLPSK TKKEFVCKFC GRHFTKSYNL LIHERTHTDE 
       210        220        230        240        250
RPYTCDICHK AFRRQDHLRD HRYIHSKEKP FKCQECGKGF CQSRTLAVHK 
       260 
TLHSQVKELK TSKIKC

Length:266

Mass (Da):29,584

Last modified:March 18, 2008 - v1

Checksum:ⁱCC9948ACFC90F7A5

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH473947 Genomic DNA Translation: EDM03089.1 BC159410 mRNA Translation: AAI59411.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001100186.1, NM_001106716.2 XP_006239948.1, XM_006239886.2
UniGeneⁱ	Rn.160611

Genome annotation databases

Ensemblⁱ	ENSRNOT00000005666; ENSRNOP00000005666; ENSRNOG00000004210
GeneIDⁱ	298878
KEGGⁱ	rno:298878

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
B0K011	Protein odd-skipped-related 1		MOUSE		266	UniRef100_Q9WVG7
Protein odd-skipped-related 1 (Fragment)		MOUSE		161

Protein	Similar proteins		Species	Score	Length	Source
B0K011	Protein odd-skipped-related 1		MOUSE		266	UniRef90_Q9WVG7
Protein odd-skipped-related 1		HUMAN		266
Uncharacterized protein		MANLE		266
Protein odd-skipped-related 1		CRIGR		266
Uncharacterized protein		RHIBE		266
+53

Protein	Similar proteins		Species	Score	Length	Source
B0K011	Protein odd-skipped-related 1		MOUSE		266	UniRef50_Q9WVG7
Protein odd-skipped-related 1		HUMAN		266
Protein odd-skipped-related 1		BOVIN		267
OSR1 isoform 1		PANTR		266
Uncharacterized protein		PANPA		266
+242

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH473947 Genomic DNA Translation: EDM03089.1 BC159410 mRNA Translation: AAI59411.1
RefSeqⁱ	NP_001100186.1, NM_001106716.2 XP_006239948.1, XM_006239886.2
UniGeneⁱ	Rn.160611

3D structure databases

ProteinModelPortalⁱ	B0K011
SMRⁱ	B0K011
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000005666

STRINGⁱ

10116.ENSRNOP00000005666

PTM databases

PhosphoSitePlusⁱ	B0K011

PhosphoSitePlusⁱ

B0K011

Proteomic databases

PaxDbⁱ	B0K011
PRIDEⁱ	B0K011

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000005666; ENSRNOP00000005666; ENSRNOG00000004210
GeneIDⁱ	298878
KEGGⁱ	rno:298878

Organism-specific databases

CTDⁱ	130497
RGDⁱ	1311807 Osr1

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00880000137939
HOGENOMⁱ	HOG000013107
HOVERGENⁱ	HBG054398
InParanoidⁱ	B0K011
KOⁱ	K09215
OMAⁱ	GPALKTK
OrthoDBⁱ	EOG091G0LRE
PhylomeDBⁱ	B0K011
TreeFamⁱ	TF350876

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:B0K011

PROⁱ

PR:B0K011

Gene expression databases

Bgeeⁱ	ENSRNOG00000004210 Expressed in 8 organ(s), highest expression level in skeletal muscle tissue

Bgeeⁱ

ENSRNOG00000004210 Expressed in 8 organ(s), highest expression level in skeletal muscle tissue

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	OSR1_RAT
Accessionⁱ	B0K011Primary (citable) accession number: B0K011
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 11, 2011
	Last sequence update:	March 18, 2008
	Last modified:	November 7, 2018
	This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

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Supporting data

UniProtKB - B0K011 (OSR1_RAT)

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Protein odd-skipped-related 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ