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Entry version 57 (12 Aug 2020)
Sequence version 1 (18 Mar 2008)
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Protein
Submitted name:

DNAH17 variant protein

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
DNAH17 variant proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection, CiliumARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
B0I1S3

PRoteomics IDEntifications database

More...
PRIDEi
B0I1S3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 328MTInterPro annotationAdd BLAST328
Domaini355 – 572AAA_9InterPro annotationAdd BLAST218
Domaini813 – 940Dynein_heavyInterPro annotationAdd BLAST128
Domaini942 – 1101AAA_lid_11InterPro annotationAdd BLAST160
Domaini1109 – 1402Dynein_CInterPro annotationAdd BLAST294

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1 – 28Sequence analysisAdd BLAST28
Coiled coili200 – 248Sequence analysisAdd BLAST49
Coiled coili516 – 536Sequence analysisAdd BLAST21
Coiled coili572 – 592Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.8.720, 1 hit
3.10.490.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035706, AAA_9
IPR041658, AAA_lid_11
IPR042219, AAA_lid_11_sf
IPR026983, DHC_fam
IPR041228, Dynein_C
IPR043160, Dynein_C_barrel
IPR024743, Dynein_HC_stalk
IPR004273, Dynein_heavy_D6_P-loop

The PANTHER Classification System

More...
PANTHERi
PTHR10676, PTHR10676, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12781, AAA_9, 1 hit
PF18198, AAA_lid_11, 1 hit
PF18199, Dynein_C, 1 hit
PF03028, Dynein_heavy, 1 hit
PF12777, MT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

B0I1S3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
VDDLKAKLAI QEAELKQKNE SADQLIQVVG IEAEKVSKEK AIADQEEVKV
60 70 80 90 100
EVINKNVTEK QKACETDLAK AEPALLAAQE ALDTLNKNNL TELKSFGSPP
110 120 130 140 150
DAVVNVTAAV MILTAPGGKI PKDKSWKAAK IMMGKVDTFL DSLKKFDKEH
160 170 180 190 200
IPEACLKAFK PYQGNPTFDP EFIRSKSTAA AGLCSWCINI VRFYEVYCDV
210 220 230 240 250
APKRQALEEA NAELAEAQEK LSRIKNKIAE LNANLSNLTS AFEKATAEKI
260 270 280 290 300
KCQQEADATN RVILLANRLV GGLASENIRW AESVENFRSQ GVTLCGDVLL
310 320 330 340 350
ISAFVSYVGY FTKKYRNELM EKFWIPYIHN LKVPIPITNG LDPLSLLTDD
360 370 380 390 400
ADVATWNNQG LPSDRMSTEN ATILGNTERW PLIVDAQLQG IKWIKNKYRS
410 420 430 440 450
ELKAIRLGQK SYLDVIEQAI SEGDTLLIEN IGETVDPVLD PLLGRNTIKK
460 470 480 490 500
GKYIKIGDKE VEYHPKFRLI LHTKYFNPHY KPEMQAQCTL INFLVTRDGL
510 520 530 540 550
EDQLLAAVVA KERPDLEQLK ANLTKSQNEF KIVLKELEDS LLARLSAASG
560 570 580 590 600
NFLGDTALVE NLETTKHTAS EIEEKVVEAK ITEVKINEAR ENYRPAAERA
610 620 630 640 650
SLLYFILNDL NKINPVYQFS LKAFNVVFEK AIQRTTPANE VKQRVINLTD
660 670 680 690 700
EITYSVYMYT ARGLFERDKL IFLAQVTFQV LSMKKELNPV ELDFLLRFPF
710 720 730 740 750
KAGVVSPVDF LQHQGWGGIK ALSEMDEFKN LDSDIEGSAK RWKKLVESEA
760 770 780 790 800
PEKEIFPKEW KNKTALQKLC MVRCLRPDRM TYAIKNFVEE KMGSKFVEGR
810 820 830 840 850
SVEFSKSYEE SSPSTSIFFI LSPGVDPLKD VEALGKKLGF TIDNGKLHNV
860 870 880 890 900
SLGQGQEVVA ENALDVAAEK GHWVILQNIH LVARWLGTLD KKLERYSTGS
910 920 930 940 950
HEDYRVFISA EPAPSPETHI IPQGILENAI KITNEPPTGM HANLHKALDL
960 970 980 990 1000
FTQDTLEMCT KEMEFKCMLF ALCYFHAVVA ERRKFGAQGW NRSYPFNNGD
1010 1020 1030 1040 1050
LTISINVLYN YLEANPKVPW DDLRYLFGEI MYGGHITDDW DRRLCRTYLA
1060 1070 1080 1090 1100
EYIRTEMLEG DVLLAPGFQI PPNLDYKGYH EYIDENLPPE SPYLYGLHPN
1110 1120 1130 1140 1150
AEIGFLTVTS EKLFRTVLEM QPKETDSGAG TGVSREEKVK AVLDDILEKI
1160 1170 1180 1190 1200
PETFNMAEIM AKAAEKTPYV VVAFQECERM NILTNEMRRS LKELNLGLKG
1210 1220 1230 1240 1250
ELTITTDVED LSTALFYDTV PDTWVARAYP SMMGLAAWYA DLLLRIRELE
1260 1270 1280 1290 1300
AWTTDFALPT TVWLAGFFNP QSFLTAIMQS MARKNEWPLD KMCLSVEVTK
1310 1320 1330 1340 1350
KNREDMTAPP REGSYVYGLF MEGARWDTQT GVIAEARLKE LTPAMPVIFI
1360 1370 1380 1390 1400
KAIPVDRMET KNIYECPVYK TRIRGPTYVW TFNLKTKEKA AKWILAAVAL

LLQV
Length:1,404
Mass (Da):158,861
Last modified:March 18, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i57EDB8AFA3387D17
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB290170 mRNA Translation: BAG06724.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB290170 mRNA Translation: BAG06724.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiB0I1S3
PRIDEiB0I1S3

Family and domain databases

Gene3Di1.10.8.720, 1 hit
3.10.490.20, 1 hit
InterProiView protein in InterPro
IPR035706, AAA_9
IPR041658, AAA_lid_11
IPR042219, AAA_lid_11_sf
IPR026983, DHC_fam
IPR041228, Dynein_C
IPR043160, Dynein_C_barrel
IPR024743, Dynein_HC_stalk
IPR004273, Dynein_heavy_D6_P-loop
PANTHERiPTHR10676, PTHR10676, 1 hit
PfamiView protein in Pfam
PF12781, AAA_9, 1 hit
PF18198, AAA_lid_11, 1 hit
PF18199, Dynein_C, 1 hit
PF03028, Dynein_heavy, 1 hit
PF12777, MT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB0I1S3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B0I1S3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 18, 2008
Last sequence update: March 18, 2008
Last modified: August 12, 2020
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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