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Entry version 66 (05 Dec 2018)
Sequence version 1 (18 Mar 2008)
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Protein
Submitted name:

DNAH6 variant protein

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
DNAH6 variant proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
B0I1R8

PRoteomics IDEntifications database

More...
PRIDEi
B0I1R8

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
B0I1R8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini180 – 333AAAInterPro annotationAdd BLAST154
Domaini531 – 689AAAInterPro annotationAdd BLAST159

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1011 – 1045Sequence analysisAdd BLAST35
Coiled coili1060 – 1080Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysisSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3595 Eukaryota
COG5245 LUCA

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG107830

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR035706 AAA_9
IPR026983 DHC_fam
IPR026980 DNAH6
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_D6_P-loop
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR10676 PTHR10676, 1 hit
PTHR10676:SF339 PTHR10676:SF339, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

B0I1R8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
VKTWMKGISK KLTEETQEYI LNLFQRYVDE GLHFINKKCS QAIPQVDISK
60 70 80 90 100
VTTLCCLLES LILGKDGVNL AMEQTKLNTI LCQTFVFCYL WSLGGNLTEN
110 120 130 140 150
YYDSFDTFIR TQFDDNPDAR LPNSGDLWSI HMDFDTKRLD PWERIIPTFK
160 170 180 190 200
YNRDVPFFEM LVPTTDTVRY GYLMEKLLAV KHSVLFTGIT GVGKSVIAKG
210 220 230 240 250
LLNKIQESAG YVPVYLNFSA QTSSARTQEI IESKLERKRK NILGAPGNKR
260 270 280 290 300
IVIFVDDLNM PRLDRYGSQP PIELLRQYQD FGGFYDRNKL FWKEIQDVTI
310 320 330 340 350
ISACAPPGGG RNPVTPRFIR HFSMLCLPMP SEHSLKQIFQ AILNGFLSDF
360 370 380 390 400
PPAVKQTASS IVEASVEIYN KMSVDLLPTP AKSHYVFNLR DLSKCVQGIL
410 420 430 440 450
QCDPGTIREE IQIFRLFCHE CQRVFHDRLI NNEDKHYFHV ILTEMANKHF
460 470 480 490 500
GIAIDLEYFL NKPIIFGDFI KFGADKADRI YDDMPDIEKT ANVLQDYLDD
510 520 530 540 550
YNLTNPKEVK LVFFQDAIEH VSRIARMIRQ ERGNALLVGV GGTGKQSLTR
560 570 580 590 600
LAAHICGYKC LQIELSRGYN YDSFHEDLRK LYKMAGVEDK NMVFLFTDTQ
610 620 630 640 650
IVVEEFLEDI NNILNSGEVP NLFEKDELEQ VLAATRPRAK EVGISEGNRD
660 670 680 690 700
EVFQYFISKV RQKLHIVLCM SPVGEAFRSR CRMFPSLVNC CTIDWFVQWP
710 720 730 740 750
REALLSVSKT FFSQVDAGNE ELKEKLPLMC VNVHLSVSSM AERYYNELRR
760 770 780 790 800
RYYTTPTSYL ELINLYLSML SEKRKQIISA RDRVKNGLTK LLETNILVDK
810 820 830 840 850
MKLDLSALEP VLLAKSEDVE ALMEKLAVDQ ESADQVRNTV QEDEATAKVK
860 870 880 890 900
AEETQAIADD AQRDLDEALP ALDAANKALD SLDKADISEI RVFTKPPDLV
910 920 930 940 950
MTVMEAISIL LNAKPDWPSA KQLLGDSNFL KRLLEYDKEN IKPQILAKLQ
960 970 980 990 1000
KYINNPDFVP EKVEKVSKAC KSMCMWVRAM DLYSRVVKVV EPKRQKLRAA
1010 1020 1030 1040 1050
QAELDITMAT LREKQALLRQ VEDQIQALQD EYDKGVNEKE SLAKTMALTK
1060 1070 1080 1090 1100
ARLVRAGKLT AALEDEQVRW EESIQKFEEE ISNITGNVFI AAACVAYYGA
1110 1120 1130 1140 1150
FTAQYRQSLI ECWIQDCQSL EIPIDPSFSL INILGDPYEI RQWNTDGLPR
1160 1170 1180 1190 1200
DLISTENGIL VTQGRRWPLM IDPQDQANRW IRNKESKSGL KIIKLTDSNF
1210 1220 1230 1240 1250
LRILENSIRL GLPVLLEELK ETLDPALEPI LLKQIFISGG RLLIRLGDSD
1260 1270 1280 1290 1300
IDYDKNFRFY MTTKMPNPHY LPEVCIKVTI INFTVTKSGL EDQLLSDVVR
1310 1320 1330 1340 1350
LEKPRLEEQR IKLIVRINTD KNQLKTIEEK ILRMLFTSEG NILDNEELID
1360 1370 1380 1390 1400
TLQDSKITSG AIKTRLEEAE STEQMINVAR EKYRPVATQG SVMYFVIASL
1410 1420 1430 1440 1450
SEIDPMYQYS LKYFKQLFNT TIETSVKTEN LQQRLDVLLE QTLLTAYVNV
1460 1470 1480 1490 1500
SRGLFEQHKL IYSFMLCVEM MRQQGTLSDA EWNFFLRGSA GLEKERPPKP
1510 1520 1530 1540 1550
EAPWLPTATW FACCDLEESF PVFHGLTQNI LSHPISIRLG SFETYINPQK
1560 1570 1580 1590 1600
WEGYSKMKHE DKHMRQEKEA AHQDPWSAGL SSFHKLILIK CCKEEKVVFA
1610 1620 1630 1640 1650
LTDFVIENLG KQFIETPPVD LPTLYQDMSC NTPLVFILST GSDPMGAFQR
1660 1670 1680 1690 1700
FARESGYSER VQSISLGQGQ GPIAEKMVKD AMKSGNWVFL QNCHLAVSWM
1710 1720 1730 1740 1750
LAMEELIKTF TDPDSAIKDT FRLFLSSMPS NTFPVTVLQN SVKVTNEPPK
1760 1770 1780 1790 1800
GLRANIRRAF TEMTPSFFEE NILGKKWRQI IFGICFFHAI IQERKKFGPL
1810 1820 1830 1840 1850
GWNICYEFND SDRECALLNL KLYCKEGKIP WDALIYITGE ITYGGRVTDS
1860 1870 1880 1890 1900
WDQRCLRTIL KRFFSPETLE EDYKYSESGI YFAPMADSLQ EFKDYIENLP
1910 1920 1930 1940 1950
LIDDPEIFGM HENANLVFQY KETSTLINTI LEVQPRSSTG GEGKSNDEIV
1960 1970 1980 1990 2000
QELVASVQTR VPEKLEMEGA SESLFVKDLQ GRLNSLTTVL GQEVDRFNNL
2010 2020 2030 2040 2050
LKLIHTSLET LNKAIAGFVV MSEEMEKVYN SFLNNQVPAL WSNTAYPSLK
2060 2070 2080 2090 2100
PLGSWVKDLI LRTSFVDLWL KRGQPKSYWI SGFFFPQGFL TGTLQNHARK
2110 2120 2130 2140 2150
YNLPIDELSF KYSVIPTYRD QAAVIEAAKT VQFGQELPMD MELPSPEDGV
2160 2170 2180 2190 2200
LVHGMFMDAS RWDDKEMVIE DALPGQMNPV LPVVHFEPQQ NYKPSPTLYH
2210 2220 2230 2240 2250
CPLYKTGARA GTLSTTGHST NFVVTVLLPS KRSKDYWIAK GSALLCQLSE
Length:2,250
Mass (Da):257,460
Last modified:March 18, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEA4499B7BA6BAE1A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB290165 mRNA Translation: BAG06719.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.249972

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB290165 mRNA Translation: BAG06719.1
UniGeneiHs.249972

3D structure databases

ProteinModelPortaliB0I1R8
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiB0I1R8
PRIDEiB0I1R8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3595 Eukaryota
COG5245 LUCA
HOVERGENiHBG107830

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR035706 AAA_9
IPR026983 DHC_fam
IPR026980 DNAH6
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_D6_P-loop
IPR027417 P-loop_NTPase
PANTHERiPTHR10676 PTHR10676, 1 hit
PTHR10676:SF339 PTHR10676:SF339, 1 hit
PfamiView protein in Pfam
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB0I1R8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B0I1R8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 18, 2008
Last sequence update: March 18, 2008
Last modified: December 5, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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