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UniProtKB - B0G138 (PKS21_DICDI)
Protein
Probable polyketide synthase 21
Gene
pks21
Organism
Dictyostelium discoideum (Slime mold)
Status
Functioni
Probable polyketide synthase.
By similarityMiscellaneous
Encoded by one of the numerous copies of polyketide synthase genes and clustered as a triplet pks19/pks20/pks21 in chromosome 3.
Cofactori
pantetheine 4'-phosphateBy similarityNote: Binds 1 phosphopantetheine covalently.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 176 | For beta-ketoacyl synthase activityPROSITE-ProRule annotation | 1 | |
Active sitei | 642 | For acyl/malonyl transferase activityPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: InterPro
- oxidoreductase activity Source: InterPro
GO - Biological processi
- fatty acid biosynthetic process Source: InterPro
Keywordsi
Molecular function | Transferase |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:pks21 ORF Names:DDB_G0282029 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0282029, pks21 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000371384 | 1 – 2779 | Probable polyketide synthase 21Add BLAST | 2779 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2319 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation | 1 |
Keywords - PTMi
Phosphopantetheine, PhosphoproteinProteomic databases
PaxDbi | B0G138 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2282 – 2359 | CarrierPROSITE-ProRule annotationAdd BLAST | 78 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 157 – 210 | Beta-ketoacyl synthaseAdd BLAST | 54 | |
Regioni | 632 – 665 | Acyl/malonyl transferaseAdd BLAST | 34 |
Domaini
Modular protein that is responsible for the completion of one condensation-processing cycle. The beta-ketoacyl synthase region is responsible for the actual condensation reaction while the acyl/malonyl transferase region is responsible for incorporating carboxylic acids units onto an acyl carrier protein (ACP) domain (By similarity).By similarity
Phylogenomic databases
eggNOGi | KOG1178, Eukaryota KOG1202, Eukaryota |
HOGENOMi | CLU_000022_31_0_1 |
InParanoidi | B0G138 |
PhylomeDBi | B0G138 |
Family and domain databases
CDDi | cd05235, SDR_e1, 1 hit |
Gene3Di | 1.10.1200.10, 1 hit 3.10.129.110, 1 hit 3.40.366.10, 1 hit 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR001227, Ac_transferase_dom_sf IPR036736, ACP-like_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR013120, Far_NAD-bd IPR011032, GroES-like_sf IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR016036, Malonyl_transacylase_ACP-bd IPR036291, NAD(P)-bd_dom_sf IPR032821, PKS_assoc IPR020841, PKS_Beta-ketoAc_synthase_dom IPR020807, PKS_dehydratase IPR042104, PKS_dehydratase_sf IPR020843, PKS_ER IPR013968, PKS_KR IPR009081, PP-bd_ACP IPR010080, Thioester_reductase-like_dom IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 1 hit PF16197, KAsynt_C_assoc, 1 hit PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit PF08659, KR, 1 hit PF07993, NAD_binding_4, 1 hit PF00550, PP-binding, 1 hit PF14765, PS-DH, 1 hit |
SMARTi | View protein in SMART SM00827, PKS_AT, 1 hit SM00829, PKS_ER, 1 hit SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF47336, SSF47336, 1 hit SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 3 hits SSF52151, SSF52151, 1 hit SSF53901, SSF53901, 1 hit SSF55048, SSF55048, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit PS50075, CARRIER, 1 hit |
i Sequence
Sequence statusi: Complete.
B0G138-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLENKEIAI VGIGFRIPQG KESINNGSVS HLWNNLKNGF SGIVETSERW
60 70 80 90 100
SDNINLLGEV NNKFGGLLPL KEWSDFDPVH FAINPSEVPL MDPQTRLLLK
110 120 130 140 150
CTWEALEDAF IDPIDIRGSN TSCFIGCSTL DYSTTNRDFN ETSENYFASN
160 170 180 190 200
VLHTISNRLS FSYDIRGPSM TIDTACSSSL NSIAMGFQSI QNGTSNLSIV
210 220 230 240 250
GGVSLLLDPY ISKSFSFLNM LSKKGKCKPF DSEADGYIRA ESCGIVILKP
260 270 280 290 300
LSDAIRDGNN IYCVINSFSS NVDGGGLNDK SNFYSPSKQS QSDNIKLALK
310 320 330 340 350
SANMKASDIS FVECHGTGTP TGDPIEVEGV SMALNSSKTS TPSKPLLIGS
360 370 380 390 400
LKSNIGHSEA ASGVASLIKC CLMFKNKHYA PNVNFDQPNP KINFKDWNIK
410 420 430 440 450
VVTEAIPFTN NNEKPVSMVI NNFGVTGSNC CLILSQFIEQ SINQNGNGHS
460 470 480 490 500
YPAESQQQQQ QRFLIPFSAN SVKSLKNYED LIINDIKIST NSFKEFVKNQ
510 520 530 540 550
IYSKSKKLYQ RSVLISSNWD QLKTKNKYFK TNNDKSSNIT IKRNQPLVVI
560 570 580 590 600
VFGGQGSQWN KMAQQLYECE PIFRSSMDKF NKELSKYYGY SVLDKLRSIK
610 620 630 640 650
DDDIISIHQP IIAQPSILML QISLFELYKH WGINVSFIVG HSLGEIATSY
660 670 680 690 700
CSGMVDFQTV CKLIYHRSIS QNNTNGCGKM LSVNISHSEF IELYSNKYPT
710 720 730 740 750
IEVACYNSPT SIVIAGNENI LKEISLNLKE NNIFCAFLGS LSSFHTSSQH
760 770 780 790 800
STKNEILPLD IPSKQSRIPT FSTVTTNLFN HETTPFNSSY VYENIIQPVR
810 820 830 840 850
FSQTISNLYQ HIENNKLGNE LIFIEVSPHP SLSFYLKQMI PKSSSYFNSV
860 870 880 890 900
SVLTSTNKKN SNDLDEIHST ISQIYCLGYD VNFKCQFNHN DDDVSSIRNS
910 920 930 940 950
KVNISLPNYQ FDEQHYWKVD INFEQYRLNG PNVFNSLGKS MINYSSNNKS
960 970 980 990 1000
YESIIDINRN PFKYLKDHIV KGKYYFPGIG YADNIMKLYP NQDIIINNLE
1010 1020 1030 1040 1050
FLAPFVLKEN VKHTLQTNVY QLGNTDYRVT FNIKDNKTNQ WVQTCTGNFQ
1060 1070 1080 1090 1100
LISLKDNNND HSSKYDINQL LSECNFTTLS KQEVYKHSRS ITGITHLGAF
1110 1120 1130 1140 1150
QGIEELYFGN DCIISKIQVN TENFDIDGKP VYQTYDKSFF NTALLDSCSQ
1160 1170 1180 1190 1200
TIVGFITNSS QFVFERLEGL KVYSENIPTD KLKYKNIYCQ AKFISLESDS
1210 1220 1230 1240 1250
YKSSVLVLLE DGTKLLEMDC ISLHSTLPLL NSLLINNPTT ELFTNNLQCK
1260 1270 1280 1290 1300
DSLVNILSID NNQTFSSISS SNTVTEIIKQ TIKPIINEKI VFRILQSFSD
1310 1320 1330 1340 1350
LELSKQIIET LNQIFDDNSL QEIDIEFTII DNSNDKLPTL HDSSLIFKND
1360 1370 1380 1390 1400
ITQLKPSYYD IIINNNNDGD DETIIKSIFN ILSSNGLLLI IGDDIGDKYN
1410 1420 1430 1440 1450
IDSLINLGFN ENKIQKSNKV IQSQKSTILS NELTVVPNNK NDNIIIYCEK
1460 1470 1480 1490 1500
ESKYTNEFMK LISNNHISCK QTIISNINEF NQLLPSITND SIIYFIKSME
1510 1520 1530 1540 1550
QLEMNNFKQI TMEYIEINQQ LLKHSLTCKH VLITIDSQIK NYLSSSIIGT
1560 1570 1580 1590 1600
ARYFNEFPSL NLYSIDFDNQ LSISSLLNKI INQLIENSNN HIQREYIIRN
1610 1620 1630 1640 1650
NSIYYEILKN EKNIKSNFNS NSFEDNDFMT LLDSTNLEYK LASKPKKLKK
1660 1670 1680 1690 1700
NQIEVKVLAT GINYKDYLIY RGLVVIDENV SISKNPLGLE FSGIITRISN
1710 1720 1730 1740 1750
ENQNCEFKVG DNVFGIACDT TASHVIADVL YVSHKPENIS HVEAASLPVI
1760 1770 1780 1790 1800
FSTCLHGMFN IGNFNIDDDE VILIHSATGG IGLATLEILK WKGHKSPIFV
1810 1820 1830 1840 1850
TVGSKDKEQY LIDNYGSFIT GIYSSRNKNY VNEIKSKLNQ LYGTTGKFNG
1860 1870 1880 1890 1900
VDLIINTLPN EFTHSNFLCL KERGKIIDLS ITHLNNNEFL NFNNFKFNKS
1910 1920 1930 1940 1950
YHNIELMHIN KKVVSRLLKS ISNALNENKL KPIPITTFQI EDVKEAIEYI
1960 1970 1980 1990 2000
NQRKHIGKIV LDHSCSNGSI GSDGLLNQLI ESDNNEKNHT ILKYDFKIDT
2010 2020 2030 2040 2050
KNIIGKNIII TGQSGIILEI LKWLIKYSPT ESFENIIILS KSSLKWELEL
2060 2070 2080 2090 2100
LINKTISRKD NNTKFHFKSV DVGDPIEMRK SINQILLENP NIDNIDSIFH
2110 2120 2130 2140 2150
YAFAQITKEV EEIDIESLDI SHNAKTMGAI NLHEISIEKS WKLKQFVMAS
2160 2170 2180 2190 2200
SIASLFGSFN QCSYVSANLV LDSLSRYRKS IGLPSTCTNW GAIKSAGFVS
2210 2220 2230 2240 2250
RNELVSKMLD DQGFIPIPTN IILGSLDLQL QNSNKNSNLI VSKFNYDSIK
2260 2270 2280 2290 2300
KLSSETSTFQ RLDFILNSIK EKDNDSNGGE NSVSESIQTK ILNKISELLS
2310 2320 2330 2340 2350
IEQSKINTDI RLSDYGADSL TSVQLKNFID KDIKSNVITL QQLQNNTIDM
2360 2370 2380 2390 2400
NIQTILEQIK KLDSNETKGK SKNIIKKDSA PTLDYWRNEM KLDESIQAIK
2410 2420 2430 2440 2450
MNPIDFRNDS KVFLTGATGF LGVHLLSNLI KSPNCSVVYC LIRNKKSEPN
2460 2470 2480 2490 2500
PINAIINNLK HHKLYHFHNE FELSKIKVIV GNLASPLLGL SKLDFDYISN
2510 2520 2530 2540 2550
QINLIINSGA DINLASNYEE SKVVNIGGFI ELIKLSTTGD YQKPIVGFSS
2560 2570 2580 2590 2600
VSVFFNASNC KEFDEETVIP TIENINNLPG GYMKSKVVVE NLLREVAKRG
2610 2620 2630 2640 2650
IPSMLIRPPI IFSHEETGIG HDSDFFQLII QSCYAVKKYP KIDKNILTSP
2660 2670 2680 2690 2700
IGWISLNTIK MIGNEKCWNK SSSNQLNIYS LNSEVSAMNP SFSFLEKQYG
2710 2720 2730 2740 2750
CEMVEYEQWK NIINQSKILS CVKLKTFHSL DDLYNIYNLG NGFGVSKKTK
2760 2770
ELLQSMNSYE GGMVNEKMIQ NHINYIFKN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000044 Genomic DNA Translation: EDR41070.1 |
RefSeqi | XP_001733001.1, XM_001732949.1 |
Genome annotation databases
EnsemblProtistsi | EDR41070; EDR41070; DDB_G0282029 |
GeneIDi | 8623374 |
KEGGi | ddi:DDB_G0282029 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000044 Genomic DNA Translation: EDR41070.1 |
RefSeqi | XP_001733001.1, XM_001732949.1 |
3D structure databases
SMRi | B0G138 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 44689.DDB0235174 |
Proteomic databases
PaxDbi | B0G138 |
Genome annotation databases
EnsemblProtistsi | EDR41070; EDR41070; DDB_G0282029 |
GeneIDi | 8623374 |
KEGGi | ddi:DDB_G0282029 |
Organism-specific databases
dictyBasei | DDB_G0282029, pks21 |
Phylogenomic databases
eggNOGi | KOG1178, Eukaryota KOG1202, Eukaryota |
HOGENOMi | CLU_000022_31_0_1 |
InParanoidi | B0G138 |
PhylomeDBi | B0G138 |
Miscellaneous databases
PROi | PR:B0G138 |
Family and domain databases
CDDi | cd05235, SDR_e1, 1 hit |
Gene3Di | 1.10.1200.10, 1 hit 3.10.129.110, 1 hit 3.40.366.10, 1 hit 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR001227, Ac_transferase_dom_sf IPR036736, ACP-like_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR013120, Far_NAD-bd IPR011032, GroES-like_sf IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR016036, Malonyl_transacylase_ACP-bd IPR036291, NAD(P)-bd_dom_sf IPR032821, PKS_assoc IPR020841, PKS_Beta-ketoAc_synthase_dom IPR020807, PKS_dehydratase IPR042104, PKS_dehydratase_sf IPR020843, PKS_ER IPR013968, PKS_KR IPR009081, PP-bd_ACP IPR010080, Thioester_reductase-like_dom IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 1 hit PF16197, KAsynt_C_assoc, 1 hit PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit PF08659, KR, 1 hit PF07993, NAD_binding_4, 1 hit PF00550, PP-binding, 1 hit PF14765, PS-DH, 1 hit |
SMARTi | View protein in SMART SM00827, PKS_AT, 1 hit SM00829, PKS_ER, 1 hit SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF47336, SSF47336, 1 hit SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 3 hits SSF52151, SSF52151, 1 hit SSF53901, SSF53901, 1 hit SSF55048, SSF55048, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit PS50075, CARRIER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PKS21_DICDI | |
Accessioni | B0G138Primary (citable) accession number: B0G138 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 5, 2009 |
Last sequence update: | March 18, 2008 | |
Last modified: | February 23, 2022 | |
This is version 84 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Dictyostelium discoideum
Dictyostelium discoideum: entries, gene names and cross-references to dictyBase