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Protein

Probable polyketide synthase 21

Gene

pks21

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Probable polyketide synthase.By similarity

Miscellaneous

Encoded by one of the numerous copies of polyketide synthase genes and clustered as a triplet pks19/pks20/pks21 in chromosome 3.

Cofactori

pantetheine 4'-phosphateBy similarityNote: Binds 1 phosphopantetheine covalently.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei176For beta-ketoacyl synthase activityPROSITE-ProRule annotation1
Active sitei642For acyl/malonyl transferase activityPROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-DDI-163765 ChREBP activates metabolic gene expression
R-DDI-199220 Vitamin B5 (pantothenate) metabolism
R-DDI-75105 Fatty acyl-CoA biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Probable polyketide synthase 21 (EC:2.3.1.-)
Short name:
dipks21
Gene namesi
Name:pks21
ORF Names:DDB_G0282029
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0282029 pks21

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003713841 – 2779Probable polyketide synthase 21Add BLAST2779

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2319O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PaxDbiB0G138
PRIDEiB0G138

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0235174

Structurei

3D structure databases

ProteinModelPortaliB0G138
SMRiB0G138
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2282 – 2359CarrierPROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni157 – 210Beta-ketoacyl synthaseAdd BLAST54
Regioni632 – 665Acyl/malonyl transferaseAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi456 – 461Poly-Gln6
Compositional biasi1364 – 1367Poly-Asn4

Domaini

Modular protein that is responsible for the completion of one condensation-processing cycle. The beta-ketoacyl synthase region is responsible for the actual condensation reaction while the acyl/malonyl transferase region is responsible for incorporating carboxylic acids units onto an acyl carrier protein (ACP) domain (By similarity).By similarity

Phylogenomic databases

eggNOGiENOG410ISPY Eukaryota
KOG1202 Eukaryota
COG3320 LUCA
COG3321 LUCA
InParanoidiB0G138
PhylomeDBiB0G138

Family and domain databases

CDDicd05235 SDR_e1, 1 hit
Gene3Di1.10.1200.10, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit
InterProiView protein in InterPro
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR011032 GroES-like_sf
IPR032821 KAsynt_C_assoc
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR013120 Male_sterile_NAD-bd
IPR016036 Malonyl_transacylase_ACP-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR020807 PKS_dehydratase
IPR020843 PKS_ER
IPR013968 PKS_KR
IPR009081 PP-bd_ACP
IPR010080 Thioester_reductase-like_dom
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PF16197 KAsynt_C_assoc, 1 hit
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PF08659 KR, 1 hit
PF07993 NAD_binding_4, 1 hit
PF14765 PS-DH, 1 hit
SMARTiView protein in SMART
SM00827 PKS_AT, 1 hit
SM00829 PKS_ER, 1 hit
SM00825 PKS_KS, 1 hit
SUPFAMiSSF47336 SSF47336, 1 hit
SSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 3 hits
SSF52151 SSF52151, 2 hits
SSF53901 SSF53901, 1 hit
SSF55048 SSF55048, 1 hit
PROSITEiView protein in PROSITE
PS00606 B_KETOACYL_SYNTHASE, 1 hit
PS50075 CARRIER, 1 hit

Sequencei

Sequence statusi: Complete.

B0G138-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLENKEIAI VGIGFRIPQG KESINNGSVS HLWNNLKNGF SGIVETSERW
60 70 80 90 100
SDNINLLGEV NNKFGGLLPL KEWSDFDPVH FAINPSEVPL MDPQTRLLLK
110 120 130 140 150
CTWEALEDAF IDPIDIRGSN TSCFIGCSTL DYSTTNRDFN ETSENYFASN
160 170 180 190 200
VLHTISNRLS FSYDIRGPSM TIDTACSSSL NSIAMGFQSI QNGTSNLSIV
210 220 230 240 250
GGVSLLLDPY ISKSFSFLNM LSKKGKCKPF DSEADGYIRA ESCGIVILKP
260 270 280 290 300
LSDAIRDGNN IYCVINSFSS NVDGGGLNDK SNFYSPSKQS QSDNIKLALK
310 320 330 340 350
SANMKASDIS FVECHGTGTP TGDPIEVEGV SMALNSSKTS TPSKPLLIGS
360 370 380 390 400
LKSNIGHSEA ASGVASLIKC CLMFKNKHYA PNVNFDQPNP KINFKDWNIK
410 420 430 440 450
VVTEAIPFTN NNEKPVSMVI NNFGVTGSNC CLILSQFIEQ SINQNGNGHS
460 470 480 490 500
YPAESQQQQQ QRFLIPFSAN SVKSLKNYED LIINDIKIST NSFKEFVKNQ
510 520 530 540 550
IYSKSKKLYQ RSVLISSNWD QLKTKNKYFK TNNDKSSNIT IKRNQPLVVI
560 570 580 590 600
VFGGQGSQWN KMAQQLYECE PIFRSSMDKF NKELSKYYGY SVLDKLRSIK
610 620 630 640 650
DDDIISIHQP IIAQPSILML QISLFELYKH WGINVSFIVG HSLGEIATSY
660 670 680 690 700
CSGMVDFQTV CKLIYHRSIS QNNTNGCGKM LSVNISHSEF IELYSNKYPT
710 720 730 740 750
IEVACYNSPT SIVIAGNENI LKEISLNLKE NNIFCAFLGS LSSFHTSSQH
760 770 780 790 800
STKNEILPLD IPSKQSRIPT FSTVTTNLFN HETTPFNSSY VYENIIQPVR
810 820 830 840 850
FSQTISNLYQ HIENNKLGNE LIFIEVSPHP SLSFYLKQMI PKSSSYFNSV
860 870 880 890 900
SVLTSTNKKN SNDLDEIHST ISQIYCLGYD VNFKCQFNHN DDDVSSIRNS
910 920 930 940 950
KVNISLPNYQ FDEQHYWKVD INFEQYRLNG PNVFNSLGKS MINYSSNNKS
960 970 980 990 1000
YESIIDINRN PFKYLKDHIV KGKYYFPGIG YADNIMKLYP NQDIIINNLE
1010 1020 1030 1040 1050
FLAPFVLKEN VKHTLQTNVY QLGNTDYRVT FNIKDNKTNQ WVQTCTGNFQ
1060 1070 1080 1090 1100
LISLKDNNND HSSKYDINQL LSECNFTTLS KQEVYKHSRS ITGITHLGAF
1110 1120 1130 1140 1150
QGIEELYFGN DCIISKIQVN TENFDIDGKP VYQTYDKSFF NTALLDSCSQ
1160 1170 1180 1190 1200
TIVGFITNSS QFVFERLEGL KVYSENIPTD KLKYKNIYCQ AKFISLESDS
1210 1220 1230 1240 1250
YKSSVLVLLE DGTKLLEMDC ISLHSTLPLL NSLLINNPTT ELFTNNLQCK
1260 1270 1280 1290 1300
DSLVNILSID NNQTFSSISS SNTVTEIIKQ TIKPIINEKI VFRILQSFSD
1310 1320 1330 1340 1350
LELSKQIIET LNQIFDDNSL QEIDIEFTII DNSNDKLPTL HDSSLIFKND
1360 1370 1380 1390 1400
ITQLKPSYYD IIINNNNDGD DETIIKSIFN ILSSNGLLLI IGDDIGDKYN
1410 1420 1430 1440 1450
IDSLINLGFN ENKIQKSNKV IQSQKSTILS NELTVVPNNK NDNIIIYCEK
1460 1470 1480 1490 1500
ESKYTNEFMK LISNNHISCK QTIISNINEF NQLLPSITND SIIYFIKSME
1510 1520 1530 1540 1550
QLEMNNFKQI TMEYIEINQQ LLKHSLTCKH VLITIDSQIK NYLSSSIIGT
1560 1570 1580 1590 1600
ARYFNEFPSL NLYSIDFDNQ LSISSLLNKI INQLIENSNN HIQREYIIRN
1610 1620 1630 1640 1650
NSIYYEILKN EKNIKSNFNS NSFEDNDFMT LLDSTNLEYK LASKPKKLKK
1660 1670 1680 1690 1700
NQIEVKVLAT GINYKDYLIY RGLVVIDENV SISKNPLGLE FSGIITRISN
1710 1720 1730 1740 1750
ENQNCEFKVG DNVFGIACDT TASHVIADVL YVSHKPENIS HVEAASLPVI
1760 1770 1780 1790 1800
FSTCLHGMFN IGNFNIDDDE VILIHSATGG IGLATLEILK WKGHKSPIFV
1810 1820 1830 1840 1850
TVGSKDKEQY LIDNYGSFIT GIYSSRNKNY VNEIKSKLNQ LYGTTGKFNG
1860 1870 1880 1890 1900
VDLIINTLPN EFTHSNFLCL KERGKIIDLS ITHLNNNEFL NFNNFKFNKS
1910 1920 1930 1940 1950
YHNIELMHIN KKVVSRLLKS ISNALNENKL KPIPITTFQI EDVKEAIEYI
1960 1970 1980 1990 2000
NQRKHIGKIV LDHSCSNGSI GSDGLLNQLI ESDNNEKNHT ILKYDFKIDT
2010 2020 2030 2040 2050
KNIIGKNIII TGQSGIILEI LKWLIKYSPT ESFENIIILS KSSLKWELEL
2060 2070 2080 2090 2100
LINKTISRKD NNTKFHFKSV DVGDPIEMRK SINQILLENP NIDNIDSIFH
2110 2120 2130 2140 2150
YAFAQITKEV EEIDIESLDI SHNAKTMGAI NLHEISIEKS WKLKQFVMAS
2160 2170 2180 2190 2200
SIASLFGSFN QCSYVSANLV LDSLSRYRKS IGLPSTCTNW GAIKSAGFVS
2210 2220 2230 2240 2250
RNELVSKMLD DQGFIPIPTN IILGSLDLQL QNSNKNSNLI VSKFNYDSIK
2260 2270 2280 2290 2300
KLSSETSTFQ RLDFILNSIK EKDNDSNGGE NSVSESIQTK ILNKISELLS
2310 2320 2330 2340 2350
IEQSKINTDI RLSDYGADSL TSVQLKNFID KDIKSNVITL QQLQNNTIDM
2360 2370 2380 2390 2400
NIQTILEQIK KLDSNETKGK SKNIIKKDSA PTLDYWRNEM KLDESIQAIK
2410 2420 2430 2440 2450
MNPIDFRNDS KVFLTGATGF LGVHLLSNLI KSPNCSVVYC LIRNKKSEPN
2460 2470 2480 2490 2500
PINAIINNLK HHKLYHFHNE FELSKIKVIV GNLASPLLGL SKLDFDYISN
2510 2520 2530 2540 2550
QINLIINSGA DINLASNYEE SKVVNIGGFI ELIKLSTTGD YQKPIVGFSS
2560 2570 2580 2590 2600
VSVFFNASNC KEFDEETVIP TIENINNLPG GYMKSKVVVE NLLREVAKRG
2610 2620 2630 2640 2650
IPSMLIRPPI IFSHEETGIG HDSDFFQLII QSCYAVKKYP KIDKNILTSP
2660 2670 2680 2690 2700
IGWISLNTIK MIGNEKCWNK SSSNQLNIYS LNSEVSAMNP SFSFLEKQYG
2710 2720 2730 2740 2750
CEMVEYEQWK NIINQSKILS CVKLKTFHSL DDLYNIYNLG NGFGVSKKTK
2760 2770
ELLQSMNSYE GGMVNEKMIQ NHINYIFKN
Length:2,779
Mass (Da):314,195
Last modified:March 18, 2008 - v1
Checksum:i8853A4F20089A375
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000044 Genomic DNA Translation: EDR41070.1
RefSeqiXP_001733001.1, XM_001732949.1

Genome annotation databases

EnsemblProtistsiEDR41070; EDR41070; DDB_G0282029
GeneIDi8623374
KEGGiddi:DDB_G0282029

Similar proteinsi

Entry informationi

Entry nameiPKS21_DICDI
AccessioniPrimary (citable) accession number: B0G138
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: March 18, 2008
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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