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UniProtKB - B0G103 (PKS10_DICDI)
Protein
Probable polyketide synthase 10
Gene
pks10
Organism
Dictyostelium discoideum (Slime mold)
Status
Functioni
Probable polyketide synthase.
By similarityMiscellaneous
Encoded by one of the numerous copies of polyketide synthase genes in chromosome 2.
Cofactori
pantetheine 4'-phosphateBy similarityNote: Binds 1 phosphopantetheine covalently.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 184 | For beta-ketoacyl synthase activityPROSITE-ProRule annotation | 1 | |
Active sitei | 646 | For acyl/malonyl transferase activityPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: InterPro
- oxidoreductase activity Source: InterPro
GO - Biological processi
- fatty acid biosynthetic process Source: InterPro
Keywordsi
Molecular function | Transferase |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:pks10 ORF Names:DDB_G0271662 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0271662, pks10 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000376885 | 1 – 2485 | Probable polyketide synthase 10Add BLAST | 2485 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2447 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation | 1 |
Keywords - PTMi
Phosphopantetheine, PhosphoproteinProteomic databases
PaxDbi | B0G103 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2410 – 2485 | CarrierPROSITE-ProRule annotationAdd BLAST | 76 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 165 – 218 | Beta-ketoacyl synthaseAdd BLAST | 54 | |
Regioni | 636 – 669 | Acyl/malonyl transferaseAdd BLAST | 34 |
Domaini
Modular protein that is responsible for the completion of one condensation-processing cycle. The beta-ketoacyl synthase region is responsible for the actual condensation reaction while the acyl/malonyl transferase region is responsible for incorporating carboxylic acids units onto an acyl carrier protein (ACP) domain (By similarity).By similarity
Phylogenomic databases
eggNOGi | KOG1202, Eukaryota |
HOGENOMi | CLU_000022_31_0_1 |
InParanoidi | B0G103 |
PhylomeDBi | B0G103 |
Family and domain databases
Gene3Di | 1.10.1200.10, 1 hit 3.10.129.110, 1 hit 3.40.366.10, 1 hit 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR001227, Ac_transferase_dom_sf IPR036736, ACP-like_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR011032, GroES-like_sf IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR016036, Malonyl_transacylase_ACP-bd IPR013217, Methyltransf_12 IPR036291, NAD(P)-bd_dom_sf IPR032821, PKS_assoc IPR020841, PKS_Beta-ketoAc_synthase_dom IPR020807, PKS_dehydratase IPR042104, PKS_dehydratase_sf IPR020843, PKS_ER IPR013968, PKS_KR IPR009081, PP-bd_ACP IPR029063, SAM-dependent_MTases IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 1 hit PF16197, KAsynt_C_assoc, 1 hit PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit PF08659, KR, 1 hit PF08242, Methyltransf_12, 1 hit PF00550, PP-binding, 1 hit PF14765, PS-DH, 1 hit |
SMARTi | View protein in SMART SM00827, PKS_AT, 1 hit SM00829, PKS_ER, 1 hit SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF47336, SSF47336, 1 hit SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit SSF52151, SSF52151, 1 hit SSF53335, SSF53335, 1 hit SSF53901, SSF53901, 1 hit SSF55048, SSF55048, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit PS50075, CARRIER, 1 hit |
i Sequence
Sequence statusi: Complete.
B0G103-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYLEKYQEDD IAIIGVGLRL PGEESGGGVV GELLNDSPQN FWNNLKKGFN
60 70 80 90 100
GISKTNERWS ENYSKLGEIS NGYAGVLPLE ELKSFDPLFF GISPSEASTI
110 120 130 140 150
DPQQRLLLKT TWESLEDAGI DHQSIRGSDC SVFIGSSTTE YRESIVNINE
160 170 180 190 200
QYLNIFGTYA HGIANRISYC FDLRGESVTL DTACASSGTA ISMGAQCIKN
210 220 230 240 250
GKSKLSIVGG VNLIVDTTNI KAFSYLNMLS TSGVCRPFDI GADGLLRGEG
260 270 280 290 300
VGTIVLKSLK DSIRDGNKIY CIIKGSSYNV DGNGNSDKQN FYAPSSISQS
310 320 330 340 350
DNIKLAIKST NGSITCDDID YFECHGTGTP TGDPIETKGI SMAFNRSKQN
360 370 380 390 400
PLLIGSLKGS SGHSEAASGV IGVIKCCLIF KNKSLVPCVN FSKPNPQIKF
410 420 430 440 450
EEWNLKVVTE PIPFTSLPSR KLNNKPISIA INNFGVTGAN CCIILSEFIN
460 470 480 490 500
NNTNDNLKQI NKSFLIPFSA NSVKSLENYK LKLNSIINEN DYYLNNSAIF
510 520 530 540 550
NGFVNNQIYN KSKSLSQRSV YVASNLNELV DGKVNFKTSN SKSSNFSILK
560 570 580 590 600
KKPIVLFVFS GQGSQYNTMF DQLYNDEIIF KESIDRIDNS LFKYYGYSVF
610 620 630 640 650
EKFKSSNLNS IHEPLIAQAA ISMLNISLFE LYKHWGIEAS FIVGHSLGEI
660 670 680 690 700
SAAHCSGMID LETLCYIIYH RSIAQIKTHG NGRMLSINQS SDEYISKYSS
710 720 730 740 750
KYADLEIACY NSQNSIVVAG NEHKLNQLFN ELKENNEFAT MIASQSSFHT
760 770 780 790 800
SNQCITKDDI FKLQFTANLP LIPIFSTVTT NLFDNSTLFN SSYIYDNIIC
810 820 830 840 850
PVRFEQTISN FYKHIDDDND KSDVEVVIIE LAPHPTLSYY LKQMKPVIEN
860 870 880 890 900
KDIKVNVYSA LHKLKNSTKE FQKVISQLYC DNGININFKC QLENQVNMYD
910 920 930 940 950
TIFSLPNYQW DDQKYWKVDY THSRSYINGP PITILGNESY NSPYLSRETY
960 970 980 990 1000
IDIKRNPFKY LNGHQIKMKI YFPGMGYIDN LLKLFKNNHK NIIIDQIEFI
1010 1020 1030 1040 1050
APLILNEGIN QCVQTNVNQI EINEYSLNCY YKDIKSNEWV KTCIGNFHIS
1060 1070 1080 1090 1100
NNLFTQQRNY NINQLINEKC NYSLIERDDL YDMIKIKTGL NYSGDFKGIN
1110 1120 1130 1140 1150
KCYIGNSCSL SEVSMNLPDN LPDKESFFNC TILDSCTHGF LVLIDYQCQL
1160 1170 1180 1190 1200
VFHKVEGLRY YNSNIPTDRN KHKNIYVYSI LNQILNDSFH SSVIIMLEDG
1210 1220 1230 1240 1250
TVLIEIDNLI SKSLTPIQDP LKIEYPMNEL FSTHLQPKDS PFPLISMTFK
1260 1270 1280 1290 1300
SKFKNINEIK NEFMLNCCKN FISNQFLSNI INRTNIKLNE IKTLTIDQLV
1310 1320 1330 1340 1350
KLYCLYNNNE RLFRFVFETI KKYDYNSNHS NNENEMVLKD DGIYQVLDTS
1360 1370 1380 1390 1400
IKVISKLLFP YENDKEDPIT ETPTSLFENG LLDKFYGTNN FMTTTIQRNL
1410 1420 1430 1440 1450
ITDIIINSLK PILNQKLVIR IVELGGGVCS FTVDFLEKLD KLLKENPFHE
1460 1470 1480 1490 1500
IEIEFTWSDI SSSFIPEAKK KLEPFSNNIN IVYRSIDIEK EFKKQGLKHS
1510 1520 1530 1540 1550
YFDFIILTNV LHVVKNIGNS LDQLYKILSP NGQILLIEPY VSIVNDSIFG
1560 1570 1580 1590 1600
SFSQWWSFED TEIRKTNCCM EPNSWLQVFK NHNFKNTNSY EEDGSCCYVI
1610 1620 1630 1640 1650
HSQKPPLLYG LNELKYTQSP NQIIIYGNEN ENENENENYT IKFNKSVIKI
1660 1670 1680 1690 1700
SNIDQFNQSI LNSQINNETI IYFTKSINQL DVNNFKFVTF EYIQINKLLL
1710 1720 1730 1740 1750
KYKLKSKHVL ITLNSRDSNY LSASLVGAKR YFEEYPQLSL KAIDFDLQSL
1760 1770 1780 1790 1800
EEIKDIQSLL IELLDENKNT QNDYIIKNCQ VYYERVKKEI ISKSKFISNS
1810 1820 1830 1840 1850
FENNDSLITQ LIDSEYKLTS NKPIFKVKEK EEGEEEVEIK VLSTTIGNVN
1860 1870 1880 1890 1900
DGDNFGEFSG IITRVCSNSN FKIGEKVYGF GYNTTSSHIV VNGDWIYYKP
1910 1920 1930 1940 1950
LNISNNNAAS IPYKYLEVLY GLYNIGELDE NENILIHLNN NINNNNNNIS
1960 1970 1980 1990 2000
TLNILKWKGH KGLIYVTVDS NEMEIYVNDN FGGFISGVFI LILKCLNSTS
2010 2020 2030 2040 2050
RIINFNYLNN NNNDNNDLEF FYKYCRKLNI GYHFIDLKKL IPIRRRGRII
2060 2070 2080 2090 2100
KDLFKEISKA IENNEINLLP IIDYSNLNIN HAIQMVKNEK NMVHTIVIEN
2110 2120 2130 2140 2150
NEDVLENLLK EHSNNSTYSI IKSDYKISEN HLGKNLIITG QIGVALEVLK
2160 2170 2180 2190 2200
WICKYSKGVE NIIILSKSLI KWELKLLIDK TYNSKENNQI KFHFNTIDIS
2210 2220 2230 2240 2250
NSNELTNTLN QLLKDTNIDN IDSIFHYAFT KVVSEVEDID LNQLNLSHGA
2260 2270 2280 2290 2300
KTMGAINLHN ESVNRCWNLK NFINASSTVT LAGSPGQCTY VCANSVLDSL
2310 2320 2330 2340 2350
SRYRKSIGLP SICSYYGSIK SGIVLRSESI ATSLEKQGYV HVSMNKFLGA
2360 2370 2380 2390 2400
LDLQIQNPNL STNLIVSNFN FKLFKNNPQH SIIDKFEHQI NENNSKLEIS
2410 2420 2430 2440 2450
TNNNPSTSTE SNKGIDGLLL SKVSELLSIN ETNFNADITL IDYGADSLIT
2460 2470 2480
SQLKNFIEKE FSLSVTSQQL QRNSINQLIK FLNKK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000006 Genomic DNA Translation: EDR41109.1 |
RefSeqi | XP_001732967.1, XM_001732915.1 |
Genome annotation databases
EnsemblProtistsi | EDR41109; EDR41109; DDB_G0271662 |
GeneIDi | 8618074 |
KEGGi | ddi:DDB_G0271662 |
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000006 Genomic DNA Translation: EDR41109.1 |
RefSeqi | XP_001732967.1, XM_001732915.1 |
3D structure databases
SMRi | B0G103 |
ModBasei | Search... |
Proteomic databases
PaxDbi | B0G103 |
Genome annotation databases
EnsemblProtistsi | EDR41109; EDR41109; DDB_G0271662 |
GeneIDi | 8618074 |
KEGGi | ddi:DDB_G0271662 |
Organism-specific databases
dictyBasei | DDB_G0271662, pks10 |
Phylogenomic databases
eggNOGi | KOG1202, Eukaryota |
HOGENOMi | CLU_000022_31_0_1 |
InParanoidi | B0G103 |
PhylomeDBi | B0G103 |
Miscellaneous databases
PROi | PR:B0G103 |
Family and domain databases
Gene3Di | 1.10.1200.10, 1 hit 3.10.129.110, 1 hit 3.40.366.10, 1 hit 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR001227, Ac_transferase_dom_sf IPR036736, ACP-like_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR011032, GroES-like_sf IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR016036, Malonyl_transacylase_ACP-bd IPR013217, Methyltransf_12 IPR036291, NAD(P)-bd_dom_sf IPR032821, PKS_assoc IPR020841, PKS_Beta-ketoAc_synthase_dom IPR020807, PKS_dehydratase IPR042104, PKS_dehydratase_sf IPR020843, PKS_ER IPR013968, PKS_KR IPR009081, PP-bd_ACP IPR029063, SAM-dependent_MTases IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 1 hit PF16197, KAsynt_C_assoc, 1 hit PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit PF08659, KR, 1 hit PF08242, Methyltransf_12, 1 hit PF00550, PP-binding, 1 hit PF14765, PS-DH, 1 hit |
SMARTi | View protein in SMART SM00827, PKS_AT, 1 hit SM00829, PKS_ER, 1 hit SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF47336, SSF47336, 1 hit SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit SSF52151, SSF52151, 1 hit SSF53335, SSF53335, 1 hit SSF53901, SSF53901, 1 hit SSF55048, SSF55048, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit PS50075, CARRIER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PKS10_DICDI | |
Accessioni | B0G103Primary (citable) accession number: B0G103 Secondary accession number(s): Q86AD4, Q86JF0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 16, 2009 |
Last sequence update: | March 18, 2008 | |
Last modified: | February 23, 2022 | |
This is version 80 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Dictyostelium discoideum
Dictyostelium discoideum: entries, gene names and cross-references to dictyBase