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UniProtKB - B0G101 (PKS8_DICDI)
Protein
Probable polyketide synthase 8/35
Gene
pks8
moreOrganism
Dictyostelium discoideum (Slime mold)
Status
Functioni
Probable polyketide synthase.
By similarityMiscellaneous
Encoded by one of the numerous copies of polyketide synthase genes and clustered as a quintuplet pks5/pks6/pks7/pks8/pks9 in chromosome 2.
Cofactori
pantetheine 4'-phosphateBy similarityNote: Binds 1 phosphopantetheine covalently.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 181 | For beta-ketoacyl synthase activityPROSITE-ProRule annotation | 1 | |
Active sitei | 645 | For acyl/malonyl transferase activityPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: InterPro
- oxidoreductase activity Source: InterPro
GO - Biological processi
- fatty acid biosynthetic process Source: InterPro
Keywordsi
Molecular function | Transferase |
Names & Taxonomyi
Protein namesi | Recommended name: Probable polyketide synthase 8/35 (EC:2.3.1.-)Short name: dipks35 Short name: dipks8 |
Gene namesi | Name:pks8 ORF Names:DDB_G0271618 AND Name:pks35 ORF Names:DDB_G0295667 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0295667, pks35 DDB_G0271618, pks8 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000376883 | 1 – 2514 | Probable polyketide synthase 8/35Add BLAST | 2514 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2468 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation | 1 |
Keywords - PTMi
Phosphopantetheine, PhosphoproteinProteomic databases
PaxDbi | B0G101 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2431 – 2508 | CarrierPROSITE-ProRule annotationAdd BLAST | 78 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 162 – 215 | Beta-ketoacyl synthaseAdd BLAST | 54 | |
Regioni | 635 – 668 | Acyl/malonyl transferaseAdd BLAST | 34 |
Domaini
Modular protein that is responsible for the completion of one condensation-processing cycle. The beta-ketoacyl synthase region is responsible for the actual condensation reaction while the acyl/malonyl transferase region is responsible for incorporating carboxylic acids units onto an acyl carrier protein (ACP) domain (By similarity).By similarity
Phylogenomic databases
eggNOGi | KOG1202, Eukaryota |
HOGENOMi | CLU_000022_31_0_1 |
InParanoidi | B0G101 |
PhylomeDBi | B0G101 |
Family and domain databases
Gene3Di | 1.10.1200.10, 1 hit 3.10.129.110, 1 hit 3.40.366.10, 1 hit 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR001227, Ac_transferase_dom_sf IPR036736, ACP-like_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR013154, ADH_N IPR011032, GroES-like_sf IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR016036, Malonyl_transacylase_ACP-bd IPR013217, Methyltransf_12 IPR036291, NAD(P)-bd_dom_sf IPR032821, PKS_assoc IPR020841, PKS_Beta-ketoAc_synthase_dom IPR020807, PKS_dehydratase IPR042104, PKS_dehydratase_sf IPR020843, PKS_ER IPR013968, PKS_KR IPR009081, PP-bd_ACP IPR029063, SAM-dependent_MTases IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 1 hit PF08240, ADH_N, 1 hit PF16197, KAsynt_C_assoc, 1 hit PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit PF08659, KR, 1 hit PF08242, Methyltransf_12, 1 hit PF14765, PS-DH, 1 hit |
SMARTi | View protein in SMART SM00827, PKS_AT, 1 hit SM00829, PKS_ER, 1 hit SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF47336, SSF47336, 1 hit SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 2 hits SSF52151, SSF52151, 1 hit SSF53335, SSF53335, 1 hit SSF53901, SSF53901, 1 hit SSF55048, SSF55048, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit PS50075, CARRIER, 1 hit |
i Sequence
Sequence statusi: Complete.
B0G101-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNNLEIINLI DKGVAIVGVG FRIPSGNNEN SICSPDDLFN NLKNGFDGVS
60 70 80 90 100
STSERWSDNF HKLGEISSPN AGLLPFNECK SFDPLFFGIN PSDAHQIDPQ
110 120 130 140 150
QRLLLKCTWE ALEDASIDPI SIRGTNTSVF IGSSNIDYQH INKHQDSVLK
160 170 180 190 200
NVIAQSAYAV SNRISYCFDF NGPSLSIDTA CSSSLNAVSQ GYHSILNGTS
210 220 230 240 250
NMSIVGGVNL ILDVGMIKAY SYLSMLSKTH GKCKAFDESG DGFTRGECAT
260 270 280 290 300
IVVLKNLQDA VKDGNRIYCV INGSSSNVDG GGHMDKVNLY SPSKQSQFNN
310 320 330 340 350
INSAFKSTNG KLSINDIQYI EAHGTGTKTG DPIETEAISM AFKNRDKSTP
360 370 380 390 400
ILIGSIKSNI GHCEAGSGVA SLIKCCLMFK YQCFLPNIHF KNPNPLIKFN
410 420 430 440 450
EWNLKVVTSP IPFNKRINEK PVSMMINNFG VTGSNCCLLI SEFKKQDYES
460 470 480 490 500
YENNNNNKSN HKNILIPFSA NSSNSLNQYQ SKFKNIINNQ FNFIDFTANQ
510 520 530 540 550
IYSKSNYLYQ RSVVIASNSN ELFEKILNKK QIQTKNSIIS NMSFKGKNPI
560 570 580 590 600
TIFVFSGQGS QYPKMALELY NNDEIFKKSI DLIDSKLSKY YGYSVWGKLT
610 620 630 640 650
TIKDDDLTSI HDPIFAQPAL CMLSVSLFEI YCHWGVNPSF ILGHSLGEIS
660 670 680 690 700
AAYCSGMIDL DTFCYTVYYR SIAQSKTNGC GRMLSINISD EEFKSMYSQK
710 720 730 740 750
YPQIEIACYN SPQSIVVAGN ESILNEISKE LKEKEIFTAM LGSLSSFHTS
760 770 780 790 800
SQQCTKDSIL QLNIESNQPK VPIFSTVTTN LFNESNRFNS QYVYDNIIKP
810 820 830 840 850
VKFTQTISNI YKHIESNQLN NDIVFIEIAP HPTISFYIKQ MVPSSLNESV
860 870 880 890 900
SVYSALHKKK NDVEEFQQTI SNLYCQNGYS INFKCQLENK KSNQSINLPL
910 920 930 940 950
YQWDDELYFA QTQTLEQYTK EGPPIDHLGL SNSYYSPFKN SYRTFIDINN
960 970 980 990 1000
KPFQYLKGHM VKGKYYFPGC GYIDIIIQLY KNQDIFISFI EFKTPLILIE
1010 1020 1030 1040 1050
GINQYLQTNI QQTGKSEYRA QFHFKDQKSN EWIQSSNANF QLLDHGNDIP
1060 1070 1080 1090 1100
SNYNIEEIIK NKCNLSKLTK NELYTQIKSK TGLNYTGVFQ GATECYLGND
1110 1120 1130 1140 1150
CSLSVLSLKS QTNSFLNIPI LDTCLHGMLV LINDQSQIVF DKAIGFKYYS
1160 1170 1180 1190 1200
SNIPSDLKEY KDSIYVYSNL KPKNADSYHG SIIVMLSDGS VLYEIQEVIF
1210 1220 1230 1240 1250
KSLIPIKHSL KIEYPNDELY KVHLQSKDSQ IPTPSSFKSI IYENDFFHSA
1260 1270 1280 1290 1300
LNIPEDLFKY ISTLFYKDII KRCPEININK INSHSVNEII SSFSKISKNQ
1310 1320 1330 1340 1350
RLFRFVFETI KENGILNSLE ENDDAYFEFN ELVIKSSKII SKLLFPLESD
1360 1370 1380 1390 1400
NDNEDLPQSL FQNGLMDKIY KCSYLRKKYQ MISHVIIHSI KEIINNNIII
1410 1420 1430 1440 1450
RILEFGGGTA SLSVEVIGEI VALLQENPNY QVEIEYTWSD ISPAFIADAK
1460 1470 1480 1490 1500
NKINKIINDA AITNGLNVIY RSLTIDESLL ENQAIKPSYY DFVIMSNVLH
1510 1520 1530 1540 1550
VVKNIKQAVE QMYQLLTPNG QLLFIEPPYK SVLIDSIIGS FEQWWSFTDT
1560 1570 1580 1590 1600
DIRKDRCGMS QQSWYQLLKT CNFKDILMSK ECIFVGSVIH AQKPPISLLN
1610 1620 1630 1640 1650
SQPKHDNIII YGGGGNLSFV ENIKLDSNSK SLIQIETIQE FNQLLSQSTI
1660 1670 1680 1690 1700
TNDSIIYFIK TLETLSLDNY KQITLEYIEI NQRLLQINSL CKHVLIVSDS
1710 1720 1730 1740 1750
RKTNYLASSV VGAARYFDEF QQLKLHTLDF DYDSTQNYIN SKNNKMVQFI
1760 1770 1780 1790 1800
NILVDSKTNV HKEMIIINNK VYYEIVQKEK NLKLKYNSES FENQNNLMCS
1810 1820 1830 1840 1850
LSPNLEYQLQ SKQIKLRDNQ VEVKTIATGI NYKDYLNFSG SNNNNGDDNT
1860 1870 1880 1890 1900
GLPQFGYEFS GIITRVGNNV KDYKVGDNVF GLSNSCTSSH IVTNFKNIQL
1910 1920 1930 1940 1950
KPSNISHNEA SSIPIDYLTS FMSLFNVGSL NIEDNESILI HLGSDSFGLS
1960 1970 1980 1990 2000
TFEILKWKGF KSNLFVTVDL DETKQYLLDR YGDFITGIYS NTDKSYVTEI
2010 2020 2030 2040 2050
KNELIKLGSK KKGVDLILNT LPSDFMDSNF ELLTKSGRII DLTSNHLNQS
2060 2070 2080 2090 2100
EFLKNINFKY NHGYHNFQLS LIQKNKIQKC LYEISHAIEN GELKTIPIKE
2110 2120 2130 2140 2150
FTNLNIKDAI KYITNGNIEK ITVSHDHEIY SDIIYRSLDE KEFSILKSNY
2160 2170 2180 2190 2200
QINSNNLGKN ILITGQSGII LEILKWIIKY SNINTIENVI ILSRSSLKWE
2210 2220 2230 2240 2250
LELLINQTKL SNNNIKFHFK SVDVGDSEQV DNAINEILNE NQQITNIDSI
2260 2270 2280 2290 2300
YHFAFQQITC KVQEINMKHL DISHGAKSMG AVNLHNQSIK RNWKLINFVM
2310 2320 2330 2340 2350
ASSALSLIGS TDQCTYACAN LLLDSFSKYR ESLGLPSACI NLGSIESTGF
2360 2370 2380 2390 2400
VSKNESISEF TDGIGYVPTP INLVLGLLDL QIQNAGKFTN SMLSNLISSK
2410 2420 2430 2440 2450
FKNIQQTSLF LKFDYLMNLN DNSEQTKKEN IGNKNIDELF IEKVSELFST
2460 2470 2480 2490 2500
DQSRINKNLR LIDYGADSLI IVQLKNWIDK EIGINLITIK QLQNNTINIS
2510
IKMILNSLMK NNQI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000006 Genomic DNA Translation: EDR41106.1 AAFI02000169 Genomic DNA Translation: EDR41032.1 |
RefSeqi | XP_001732964.1, XM_001732912.1 XP_001733036.1, XM_001732984.1 |
Genome annotation databases
EnsemblProtistsi | EDR41032; EDR41032; DDB_G0295667 EDR41106; EDR41106; DDB_G0271618 |
GeneIDi | 8618020 8627806 |
KEGGi | ddi:DDB_G0271618 ddi:DDB_G0295667 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000006 Genomic DNA Translation: EDR41106.1 AAFI02000169 Genomic DNA Translation: EDR41032.1 |
RefSeqi | XP_001732964.1, XM_001732912.1 XP_001733036.1, XM_001732984.1 |
3D structure databases
SMRi | B0G101 |
ModBasei | Search... |
Proteomic databases
PaxDbi | B0G101 |
Genome annotation databases
EnsemblProtistsi | EDR41032; EDR41032; DDB_G0295667 EDR41106; EDR41106; DDB_G0271618 |
GeneIDi | 8618020 8627806 |
KEGGi | ddi:DDB_G0271618 ddi:DDB_G0295667 |
Organism-specific databases
dictyBasei | DDB_G0295667, pks35 DDB_G0271618, pks8 |
Phylogenomic databases
eggNOGi | KOG1202, Eukaryota |
HOGENOMi | CLU_000022_31_0_1 |
InParanoidi | B0G101 |
PhylomeDBi | B0G101 |
Miscellaneous databases
PROi | PR:B0G101 |
Family and domain databases
Gene3Di | 1.10.1200.10, 1 hit 3.10.129.110, 1 hit 3.40.366.10, 1 hit 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR001227, Ac_transferase_dom_sf IPR036736, ACP-like_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR013154, ADH_N IPR011032, GroES-like_sf IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR016036, Malonyl_transacylase_ACP-bd IPR013217, Methyltransf_12 IPR036291, NAD(P)-bd_dom_sf IPR032821, PKS_assoc IPR020841, PKS_Beta-ketoAc_synthase_dom IPR020807, PKS_dehydratase IPR042104, PKS_dehydratase_sf IPR020843, PKS_ER IPR013968, PKS_KR IPR009081, PP-bd_ACP IPR029063, SAM-dependent_MTases IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 1 hit PF08240, ADH_N, 1 hit PF16197, KAsynt_C_assoc, 1 hit PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit PF08659, KR, 1 hit PF08242, Methyltransf_12, 1 hit PF14765, PS-DH, 1 hit |
SMARTi | View protein in SMART SM00827, PKS_AT, 1 hit SM00829, PKS_ER, 1 hit SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF47336, SSF47336, 1 hit SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 2 hits SSF52151, SSF52151, 1 hit SSF53335, SSF53335, 1 hit SSF53901, SSF53901, 1 hit SSF55048, SSF55048, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit PS50075, CARRIER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PKS8_DICDI | |
Accessioni | B0G101Primary (citable) accession number: B0G101 Secondary accession number(s): Q86AE5, Q86JI2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 16, 2009 |
Last sequence update: | March 18, 2008 | |
Last modified: | February 23, 2022 | |
This is version 84 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Dictyostelium discoideum
Dictyostelium discoideum: entries, gene names and cross-references to dictyBase