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UniProtKB - B0G0Z9 (PKS6_DICDI)
Protein
Probable polyketide synthase 6
Gene
pks6
Organism
Dictyostelium discoideum (Slime mold)
Status
Functioni
Probable polyketide synthase.
By similarityMiscellaneous
Encoded by one of the numerous copies of polyketide synthase genes and clustered as a quintuplet pks5/pks6/pks7/pks8/pks9 in chromosome 2.
Cofactori
pantetheine 4'-phosphateBy similarityNote: Binds 1 phosphopantetheine covalently.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 181 | For beta-ketoacyl synthase activityPROSITE-ProRule annotation | 1 | |
Active sitei | 645 | For acyl/malonyl transferase activityPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: InterPro
- oxidoreductase activity Source: InterPro
GO - Biological processi
- fatty acid biosynthetic process Source: InterPro
Keywordsi
Molecular function | Transferase |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:pks6 ORF Names:DDB_G0271524 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0271524, pks6 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 2551 – 2571 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000376881 | 1 – 2924 | Probable polyketide synthase 6Add BLAST | 2924 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2468 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation | 1 |
Keywords - PTMi
Phosphopantetheine, PhosphoproteinProteomic databases
PaxDbi | B0G0Z9 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2431 – 2508 | CarrierPROSITE-ProRule annotationAdd BLAST | 78 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 162 – 215 | Beta-ketoacyl synthaseAdd BLAST | 54 | |
Regioni | 635 – 668 | Acyl/malonyl transferaseAdd BLAST | 34 |
Domaini
Modular protein that is responsible for the completion of one condensation-processing cycle. The beta-ketoacyl synthase region is responsible for the actual condensation reaction while the acyl/malonyl transferase region is responsible for incorporating carboxylic acids units onto an acyl carrier protein (ACP) domain (By similarity).By similarity
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1202, Eukaryota KOG1221, Eukaryota |
HOGENOMi | CLU_000022_31_0_1 |
InParanoidi | B0G0Z9 |
PhylomeDBi | B0G0Z9 |
Family and domain databases
CDDi | cd05235, SDR_e1, 1 hit |
Gene3Di | 1.10.1200.10, 1 hit 3.10.129.110, 1 hit 3.40.366.10, 1 hit 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR001227, Ac_transferase_dom_sf IPR036736, ACP-like_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR013154, ADH_N IPR013120, Far_NAD-bd IPR011032, GroES-like_sf IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR016036, Malonyl_transacylase_ACP-bd IPR013217, Methyltransf_12 IPR036291, NAD(P)-bd_dom_sf IPR032821, PKS_assoc IPR020841, PKS_Beta-ketoAc_synthase_dom IPR020807, PKS_dehydratase IPR042104, PKS_dehydratase_sf IPR020843, PKS_ER IPR013968, PKS_KR IPR009081, PP-bd_ACP IPR029063, SAM-dependent_MTases IPR010080, Thioester_reductase-like_dom IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 1 hit PF08240, ADH_N, 1 hit PF16197, KAsynt_C_assoc, 1 hit PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit PF08659, KR, 1 hit PF08242, Methyltransf_12, 1 hit PF07993, NAD_binding_4, 1 hit PF14765, PS-DH, 1 hit |
SMARTi | View protein in SMART SM00827, PKS_AT, 1 hit SM00829, PKS_ER, 1 hit SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF47336, SSF47336, 1 hit SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 3 hits SSF52151, SSF52151, 1 hit SSF53335, SSF53335, 1 hit SSF53901, SSF53901, 1 hit SSF55048, SSF55048, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit PS50075, CARRIER, 1 hit |
i Sequence
Sequence statusi: Complete.
B0G0Z9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNNLKNIDLI EKGVAIVGIG FRIPSGNNEN SICSPDDLFN NLKNGFDGVS
60 70 80 90 100
STSERWSDNY HKLGEISSPN AGLLPLNEWK SFDPLFFGIN PSEASLIDPQ
110 120 130 140 150
QRLLLKCTWE ALEDASIDPI SIRGTNTSVF IGASNIDYQH TNKHQDSVLK
160 170 180 190 200
NAIAQSTCAI SNRISYCFDF NGPSLSIDTA CSSSLNAVSQ GYHSILNGTS
210 220 230 240 250
DISIVGGVNL ILDVEMTKAY SYLSMLSKTH GKCKAFDESG DGFTRGECVG
260 270 280 290 300
VVVLKNLQDA IKDGNRIYCV INGSSSNVDG NGNMDKVNFY SPSKQSQFNN
310 320 330 340 350
INSAFKSTND KLSINDIQYI EAHGTGTKTG DPIETEAISM AFKNRDKSAP
360 370 380 390 400
ILIGSIKSNI GHCEAGSGVA SLIKCCLMFK YQCFLPNIHF KNPNPLIKFN
410 420 430 440 450
EWNLKVVTSP IPFNKRNNEK PVSMMINNFG VTGSNCCLLI SEFKNNNNFK
460 470 480 490 500
ENINLESQSV NDRVLIPFSA NSSNSLNQYQ SKFKNIINNQ FNFIDFTAIQ
510 520 530 540 550
IYSKSNYLYQ RSVVIASNSN ELFENISNKK QIQTKNSIIS NMSFKGKNPI
560 570 580 590 600
TIFVFSGQGS QYPKMALELY NNEVIFKKSI DLIDSKLSKY YGFSVWEKVK
610 620 630 640 650
TIKDDDLTSI HDPIFAQPAL CMISVSLFEL YYHWGVNPSF ILGHSLGEIS
660 670 680 690 700
ASYCSGMIDL DTFCYTVYQR SIAQSKTNGC GRMLSINISD EEFKSMYSQK
710 720 730 740 750
YPQIEIACYN SPQSIVVAGN ESILNEISKE LKEKEIFTAM LGSLSSFHTS
760 770 780 790 800
SQQSTKDSIL QLNIESNQPK VPIFSTVTTN LFNESNRFNS QYVYDNIIKP
810 820 830 840 850
VKFTQTISNI YKHIESNQLD NDIVFIEIAP HPTLSFYIKQ MVPSSLNESV
860 870 880 890 900
SVYSALHKKK NDVEEFQQTI SNLYCQNGYN INFKCQFNNK KSNLNIELPL
910 920 930 940 950
YQWSDELYFA QNQVLEQHRK GGPPIDHLGL SNSYYSPFKN SYKTLIDINY
960 970 980 990 1000
KPFQYLKGHM VKGKYYFPGC GYIDNIIQLY KNQDIFISFI EFKTPLILIE
1010 1020 1030 1040 1050
GINQYLQTNI QQTGKSEYRA QFHFKDHKSN EWIQSSNSNF QLLDHGNDIP
1060 1070 1080 1090 1100
SNYNIKEIIK NKCNLSKLTK NELYKNIKSK TGLNYTGVFQ GVTECYIGDN
1110 1120 1130 1140 1150
CTLSVVSLES QTNSFLNIPI LDTCLHGMLI LINDQCQIVF DKAIGFKYYS
1160 1170 1180 1190 1200
SNIPADFKEN KDSFYVYSNL RPRVGGDSYH GTIIVMLSDG SVLYEIEEVV
1210 1220 1230 1240 1250
CKSLIPIKDS LKIEYPNDEL YKVHLQSKDS PIPTPSSFKS IIYENDFFQS
1260 1270 1280 1290 1300
SLNIPEDLFK YISTLFYKDI IKRCPEININ KINSHSVNEI ISSFSKISKH
1310 1320 1330 1340 1350
ERLFRFVFET IKENGILNSF EEKDDTYFEF NKVIIKSSRI ISKLLFPLEN
1360 1370 1380 1390 1400
DNDNEDLPQS LFQNGLMDKI YKCSYLRKKN QVISHVIKHS IKEIINNNII
1410 1420 1430 1440 1450
IRILEFGGGT ASLSVEVIEE IVTLLQENPN YQVEIEYTWS DISPAFIADA
1460 1470 1480 1490 1500
KNKINKIIND AAITNGLNVI YHPLTIGESL IETQSIKPSY YDFVIMSNVL
1510 1520 1530 1540 1550
HVVKDIKQAV EQMYQLLTTN GQLVFLEPPY KSVLNDSIVG SFEQWWSFTD
1560 1570 1580 1590 1600
TDIRKDRCGM PQQSWYQLLN SCNFKDIVMS KECIFFGSVI QAQKPPISLL
1610 1620 1630 1640 1650
NSQPKYDNII IYGGSINSSF VENIKLDSNS KSLFQIETIQ EFNKLISKST
1660 1670 1680 1690 1700
ITNDSIVYFI KTLETLSLDN FKQITLEYIE INQKLLQINS LCKHVLIVSD
1710 1720 1730 1740 1750
SRKTNYLASS AIGAARYFDE FPLLKLHTLD FDYDSTQNYI NSKNNKMVQF
1760 1770 1780 1790 1800
INILTDSKTN VHKEMIIINN KVYYEIVQKE KNLKLKYNSE SFENQNNLMC
1810 1820 1830 1840 1850
SLSPNLEYQL QSKQIKLRDN QVEVKTIATG INYKDYLNFS GSNSNGDDNT
1860 1870 1880 1890 1900
GLPQFGYEFS GIITRVGNNV KDYKVGDNVF GLSNSCTSSH IVTNFKKIQI
1910 1920 1930 1940 1950
KPSKISHIEA SSIPIDYLTS FMSLFNVGSL NIEDNESILI HLGRDGFGLS
1960 1970 1980 1990 2000
TFEILKWKGF KSNLFVTVNS DKTKQYLLKK YGDLITGIYS NTDKSYVAEI
2010 2020 2030 2040 2050
KNKLIKLGSK KKGVDLILNT LPSDFMDSNF KLLTKYGRII DLNSNHLNQS
2060 2070 2080 2090 2100
EFLKNINFKY NHGYHNFELS LFQKNKILKC LNEISNAIEN GELKTIPIKE
2110 2120 2130 2140 2150
FTNLNIKDAI KYITNGNIEK ITVSHDHEIY SDIIYRYLDE KEFSILKSNY
2160 2170 2180 2190 2200
QINSNNLGKN ILITGQSGII LEILKWIIKY SNINTIENVI ILSRSSLKWE
2210 2220 2230 2240 2250
LELLINQTKL SNNNIKFHFK SVDVGDSEQV DNAINDILNE NQQIRNIDSI
2260 2270 2280 2290 2300
FHFAFQQIAC KVQEINMKHL NISHGAKSMG AINLHNQSIK RNWKLINFVM
2310 2320 2330 2340 2350
ASSALSFIDS TDQCTYACAN TLLDSFSKYR VSLGLPSTCI NLGLIESTGF
2360 2370 2380 2390 2400
VSKNESISVF LDGNGIIPTP INRVLGLLDL QIQNASKFTN SMISNFKPSK
2410 2420 2430 2440 2450
FKNNQQISLF LKFDYLMNLK NNSEQTKKEN TGNKNIDELF IEKVSELFSM
2460 2470 2480 2490 2500
DESKINKNLR LIDYGADSLI IVQLKNWIDK EIGINLITIQ QLQNNTINIS
2510 2520 2530 2540 2550
IKMILNSLMK NNQNKYLPSN RIDYWKNEMK FEESIKPIPN EIRSRNNNSG
2560 2570 2580 2590 2600
KIILLTGTTG FLGGFLLFNM LRLDSCKLIY CLIRNKSKSS YPLDEIINNL
2610 2620 2630 2640 2650
KYHQLYEKLN KSQISKIIPI IGDLSMNKLG LSNDDYETIS KNVNLIINPG
2660 2670 2680 2690 2700
ADINQKSSYQ DCKLVNVNGV KEIIKLSLSS LKQRIPIVNF SSFSVFFNQS
2710 2720 2730 2740 2750
LDKNFDESVL PSIDNIDNLP TEYMKSKVVG EYILLEASKN YNIPSILIRP
2760 2770 2780 2790 2800
PSIFLNPETG IGHSSDLTLL MIQSCYELGY CPNQILNGFI LINTITWLSN
2810 2820 2830 2840 2850
NITNIIMNDN CWTNSKMNIY NVHGKQIQSS LIIKPLEKHF NCKQINNNDW
2860 2870 2880 2890 2900
IDMVNNSNKK SCIKLKSFHS LENIFKSENK GYKSNESQSI SLSTKSLLES
2910 2920
MGSYNTDLKI TDKMIISHIK HIFK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000006 Genomic DNA Translation: EDR41104.1 |
RefSeqi | XP_001732962.1, XM_001732910.1 |
Genome annotation databases
EnsemblProtistsi | EDR41104; EDR41104; DDB_G0271524 |
GeneIDi | 8618015 |
KEGGi | ddi:DDB_G0271524 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000006 Genomic DNA Translation: EDR41104.1 |
RefSeqi | XP_001732962.1, XM_001732910.1 |
3D structure databases
SMRi | B0G0Z9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 44689.DDB0235162 |
Proteomic databases
PaxDbi | B0G0Z9 |
Genome annotation databases
EnsemblProtistsi | EDR41104; EDR41104; DDB_G0271524 |
GeneIDi | 8618015 |
KEGGi | ddi:DDB_G0271524 |
Organism-specific databases
dictyBasei | DDB_G0271524, pks6 |
Phylogenomic databases
eggNOGi | KOG1202, Eukaryota KOG1221, Eukaryota |
HOGENOMi | CLU_000022_31_0_1 |
InParanoidi | B0G0Z9 |
PhylomeDBi | B0G0Z9 |
Miscellaneous databases
PROi | PR:B0G0Z9 |
Family and domain databases
CDDi | cd05235, SDR_e1, 1 hit |
Gene3Di | 1.10.1200.10, 1 hit 3.10.129.110, 1 hit 3.40.366.10, 1 hit 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR001227, Ac_transferase_dom_sf IPR036736, ACP-like_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR013154, ADH_N IPR013120, Far_NAD-bd IPR011032, GroES-like_sf IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR016036, Malonyl_transacylase_ACP-bd IPR013217, Methyltransf_12 IPR036291, NAD(P)-bd_dom_sf IPR032821, PKS_assoc IPR020841, PKS_Beta-ketoAc_synthase_dom IPR020807, PKS_dehydratase IPR042104, PKS_dehydratase_sf IPR020843, PKS_ER IPR013968, PKS_KR IPR009081, PP-bd_ACP IPR029063, SAM-dependent_MTases IPR010080, Thioester_reductase-like_dom IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 1 hit PF08240, ADH_N, 1 hit PF16197, KAsynt_C_assoc, 1 hit PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit PF08659, KR, 1 hit PF08242, Methyltransf_12, 1 hit PF07993, NAD_binding_4, 1 hit PF14765, PS-DH, 1 hit |
SMARTi | View protein in SMART SM00827, PKS_AT, 1 hit SM00829, PKS_ER, 1 hit SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF47336, SSF47336, 1 hit SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 3 hits SSF52151, SSF52151, 1 hit SSF53335, SSF53335, 1 hit SSF53901, SSF53901, 1 hit SSF55048, SSF55048, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit PS50075, CARRIER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PKS6_DICDI | |
Accessioni | B0G0Z9Primary (citable) accession number: B0G0Z9 Secondary accession number(s): Q86AE8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 16, 2009 |
Last sequence update: | March 18, 2008 | |
Last modified: | February 23, 2022 | |
This is version 83 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Dictyostelium discoideum
Dictyostelium discoideum: entries, gene names and cross-references to dictyBase