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Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

6pgd

Organism
Leishmania braziliensis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.UniRule annotation

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 3 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase (LBRM_20_0160), Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase (G6PD)
  2. no protein annotated in this organism
  3. 6-phosphogluconate dehydrogenase, decarboxylating (6pgd), 6-phosphogluconate dehydrogenase, decarboxylating (6pgd), 6-phosphogluconate dehydrogenase, decarboxylating (6PGD)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei105NADPUniRule annotation1
Binding sitei105SubstrateUniRule annotation1
Active sitei186Proton acceptorUniRule annotation1
Active sitei193Proton donorUniRule annotation1
Binding sitei194SubstrateUniRule annotation1
Binding sitei263Substrate; via amide nitrogenUniRule annotation1
Binding sitei290SubstrateUniRule annotation1
Binding sitei454Substrate; shared with dimeric partnerUniRule annotation1
Binding sitei460Substrate; shared with dimeric partnerUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 14NADPUniRule annotation6
Nucleotide bindingi32 – 34NADPUniRule annotation3
Nucleotide bindingi77 – 79NADPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processGluconate utilizationUniRule annotation, Pentose shuntUniRule annotation
LigandNADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00115; UER00410

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylatingUniRule annotation (EC:1.1.1.44UniRule annotation)
Gene namesi
Name:6pgdImported
OrganismiLeishmania braziliensisImported
Taxonomic identifieri5660 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmaniaLeishmania braziliensis species complex

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei414 – 436HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB0FGJ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini182 – 4766PGDInterPro annotationAdd BLAST295

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni131 – 133Substrate bindingUniRule annotation3
Regioni189 – 190Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the 6-phosphogluconate dehydrogenase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2653 Eukaryota
COG0362 LUCA

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006114 6PGDH_C
IPR006113 6PGDH_Gnd/GntZ
IPR006115 6PGDH_NADP-bd
IPR006184 6PGdom_BS
IPR036291 NAD(P)-bd_dom_sf
IPR006183 Pgluconate_DH
PfamiView protein in Pfam
PF00393 6PGD, 1 hit
PF03446 NAD_binding_2, 1 hit
PIRSFiPIRSF000109 6PGD, 1 hit
PRINTSiPR00076 6PGDHDRGNASE
SMARTiView protein in SMART
SM01350 6PGD, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00873 gnd, 1 hit
PROSITEiView protein in PROSITE
PS00461 6PGD, 1 hit

Sequencei

Sequence statusi: Complete.

B0FGJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNDLGIIGL GVMGANLALN IAEKHFKVAV YNRTCSKTHD FLKEHEHETF
60 70 80 90 100
ASNLQGYETM KEFAASLKKP RRAFILVQAG AATDSTIEQL KVVFENGDII
110 120 130 140 150
IDTGNANFKD QSRRAAQLES QGLRFLGMGI SGGEEGARKG PAFFPGGTPS
160 170 180 190 200
VWEEVRPIVE AASAKAEDGR PCVTFNGKGG AGSCVKMYHN AGEYAILQIW
210 220 230 240 250
GEAYSALQAL GFNNDQVADV FESWKAGGFL KSYMLDISIA ACRAKEPAGN
260 270 280 290 300
YLSEKVKDCI GSKGTGLWSA QEALEVGVPA PSLNMAVISR QMTMCKDERA
310 320 330 340 350
ENFKAFPTFP CSVREQXKDK SPNAPEVKQL YHAVSLSIIA SYAQMFQCLR
360 370 380 390 400
ELDKVHGFGL NLPATIATFR AGCILQGYLL IPMTKAFEEN PNLPNLMDAF
410 420 430 440 450
TKEMKEGLPA YRQIVAMLTA STAVSLPVMT ASLAYINAMY TLILPYGQLV
460 470
SLQRDVFGRH GYERVDKEGR ESFTWPAMQ
Length:479
Mass (Da):52,384
Last modified:February 26, 2008 - v1
Checksum:iBC64900367C8C2CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU327920 Genomic DNA Translation: ABY50511.1

Similar proteinsi

Entry informationi

Entry nameiB0FGJ4_LEIBR
AccessioniPrimary (citable) accession number: B0FGJ4
Entry historyiIntegrated into UniProtKB/TrEMBL: February 26, 2008
Last sequence update: February 26, 2008
Last modified: March 28, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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