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Protein
Submitted name:

Suppressor of cytokine signaling 5

Gene

socs5a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.SAAS annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-DRE-8951664 Neddylation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Submitted name:
Suppressor of cytokine signaling 5Imported
Submitted name:
Suppressor of cytokine-signaling 5aImported
Gene namesi
Name:socs5aImported
Synonyms:SOCS5Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 12

Organism-specific databases

ZFINiZDB-GENE-061013-408 socs5a

Subcellular locationi

PTM / Processingi

Proteomic databases

PRIDEiB0EVP7

Expressioni

Gene expression databases

BgeeiENSDARG00000100717 Expressed in 18 organ(s), highest expression level in embryo

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000102564

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini373 – 468SH2InterPro annotationAdd BLAST96
Domaini463 – 512SOCS boxInterPro annotationAdd BLAST50

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4566 Eukaryota
ENOG4111V4J LUCA
GeneTreeiENSGT00760000119136
HOGENOMiHOG000027791
HOVERGENiHBG054138
OMAiLARATIC
OrthoDBiEOG091G0EQ0

Family and domain databases

Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR022252 SOCS4/SOCS5_dom
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF12610 SOCS, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50225 SOCS, 1 hit

Sequencei

Sequence statusi: Complete.

B0EVP7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKVGKVWSN LKRGCQSLLH TDGGSRVETS PQHQPQTDTV CHSVDGAQGD
60 70 80 90 100
ITLDANSPSS SVAALPLVAW RTSGSVTRRG HNCVADVPQI LEITVEQDAD
110 120 130 140 150
DARAPLGARR DSYSRHAPWS GKKRHSCSTK AQSSLETTDR RSGRSRRRHG
160 170 180 190 200
TSNSPEELES GTTRSIRQQI HDTVGLCLPL RSSSRNTHLP PPKRKIQITE
210 220 230 240 250
LMLETCPFAP GSDLARKWHL IKQHTAPINV IPLDSSPDAC GATCASPEDE
260 270 280 290 300
EERLRERRRL SIEEGVDPPP DAQIHTVEAI TAPLASLYKL GPKLAPGMGE
310 320 330 340 350
AVGDSRGAAA ANCDSEDDET TTLCLQARKP KQWQASGEGH PSSKQPGPWK
360 370 380 390 400
VHTQIDYIHC LVPDLLQITA LPCYWGVMDR YEAEALLDGR PEGTFLLRDS
410 420 430 440 450
AQEDYLFSVS FRRYGRSLHA RIEQWNHNFS FDAHDPCVFH AATVTALLEH
460 470 480 490 500
YKDPSACMFF EPLLTVPLHR TFPFGLQSLA RAAICHGITY DGIGALPLPP
510 520
ALQDYLREYH YKQRVRVRWL EREPVKAK
Length:528
Mass (Da):58,617
Last modified:February 26, 2008 - v1
Checksum:i97AE0573FB70880C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR385067 Genomic DNA No translation available.
EF195763 mRNA Translation: ABM68036.1
RefSeqiNP_001107230.1, NM_001113758.1
UniGeneiDr.117259

Genome annotation databases

EnsembliENSDART00000159167; ENSDARP00000137510; ENSDARG00000100717
GeneIDi768142
KEGGidre:768142

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR385067 Genomic DNA No translation available.
EF195763 mRNA Translation: ABM68036.1
RefSeqiNP_001107230.1, NM_001113758.1
UniGeneiDr.117259

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000102564

Proteomic databases

PRIDEiB0EVP7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000159167; ENSDARP00000137510; ENSDARG00000100717
GeneIDi768142
KEGGidre:768142

Organism-specific databases

CTDi768142
ZFINiZDB-GENE-061013-408 socs5a

Phylogenomic databases

eggNOGiKOG4566 Eukaryota
ENOG4111V4J LUCA
GeneTreeiENSGT00760000119136
HOGENOMiHOG000027791
HOVERGENiHBG054138
OMAiLARATIC
OrthoDBiEOG091G0EQ0

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-DRE-8951664 Neddylation

Gene expression databases

BgeeiENSDARG00000100717 Expressed in 18 organ(s), highest expression level in embryo

Family and domain databases

Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR022252 SOCS4/SOCS5_dom
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF12610 SOCS, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50225 SOCS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB0EVP7_DANRE
AccessioniPrimary (citable) accession number: B0EVP7
Entry historyiIntegrated into UniProtKB/TrEMBL: February 26, 2008
Last sequence update: February 26, 2008
Last modified: November 7, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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