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Protein

RNA polymerase II transcription factor B subunit 2

Gene

LACBIDRAFT_257057

Organism
Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686) (Bicoloured deceiver) (Laccaria laccata var. bicolor)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II transcription factor B subunit 2UniRule annotation
Gene namesi
ORF Names:LACBIDRAFT_257057Imported
OrganismiLaccaria bicolor (strain S238N-H82 / ATCC MYA-4686) (Bicoloured deceiver) (Laccaria laccata var. bicolor)Imported
Taxonomic identifieri486041 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesTricholomataceaeLaccaria
Proteomesi
  • UP000001194 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi486041.XP_001891159.1

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3471 Eukaryota
COG5144 LUCA
InParanoidiB0E4P1
KOiK03144
OrthoDBiEOG092C3703

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit
TIGRFAMsiTIGR00625 tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

B0E4P1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSARPYVYA DGNVHQRKAH ALLPFLQSQS QNTLTKLYSK PSSCLSIFRL
60 70 80 90 100
LDPISRQLIM NLLWLESAIP ASTMQAWVTR EGKPVYTEAL ATLTKLHIFP
110 120 130 140 150
NSAIKLAVVP TFKTSFRQAI TGGGTSGSFG VPSEKDDKRS DVDIEFLDVF
160 170 180 190 200
ALERWETILH YMVSSGSGQN PTKPSVRVLF LLQRSGLMTT VGQGPLQITS
210 220 230 240 250
AGFQFLLHSP HEQLWELLLQ YLHLTEERQM DLVDVLGFLF MLSTMELGRE
260 270 280 290 300
YSTERLSKTQ TAMLEDLVDY GLIWRRKPSS KGFHPTRLAT TLTSSSPPLP
310 320 330 340 350
SSIGNRSGPQ EGFIVLETNY RIYAYTDNPL QTAILNLFVS LKYRFPNLVV
360 370 380 390 400
GAITRDSVKK ALLNGISADQ IISYLMSHAH PQMRKNVRLR SCNPLLPVTV
410 420 430 440 450
QDQIRLWELE KNRLKSQEGY LYTSFASQAD YDFVLNYAKE LGVVLWENPV
460 470
KRCFFGSLDG HANIRGFIER RTGAG
Length:475
Mass (Da):53,545
Last modified:February 26, 2008 - v1
Checksum:iEDA522B08324CB79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS547472 Genomic DNA Translation: EDQ98188.1
RefSeqiXP_001891159.1, XM_001891124.1

Genome annotation databases

EnsemblFungiiEDQ98188; EDQ98188; LACBIDRAFT_257057
GeneIDi6086816
KEGGilbc:LACBIDRAFT_257057

Similar proteinsi

Entry informationi

Entry nameiB0E4P1_LACBS
AccessioniPrimary (citable) accession number: B0E4P1
Entry historyiIntegrated into UniProtKB/TrEMBL: February 26, 2008
Last sequence update: February 26, 2008
Last modified: March 28, 2018
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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