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Entry version 7 (02 Jun 2021)
Sequence version 1 (02 Nov 2016)
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Protein

Nephrocystin-4

Gene

nphp4

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the organization of apical junctions (By similarity).

Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit int to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as daam1 (PubMed:26644512).

May downregulate the canonical Wnt pathway and promote the Wnt-PCP pathway. Acts as negative regulator of the hippo pathway (By similarity).

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nephrocystin-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nphp4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004375751 – 1430Nephrocystin-4Add BLAST1430

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In the embryo expressed in the neural folds and the presumptive eye at stage 18. At stage 24 expressed in multiciliated cells of the epidermis. Also detected in the brain, spinal code, eye, olfactory placode, and cloaca. At stage 32 expressed in the pronephric duct, nephrostrome, cloaca, somites, posterior spinal cord, eye, branchial arch, otic vesicle, and fore-, mid-, and hindbrain.1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B0DOB4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni824 – 1430Sufficient for basal bodies localizationBy similarityAdd BLAST607
Regioni828 – 857DisorderedSequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi828 – 843Basic and acidic residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NPHP4 family.Curated

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029775, NPHP4

The PANTHER Classification System

More...
PANTHERi
PTHR31043, PTHR31043, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B0DOB4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKDWENIFSQ SHIIPPHKQR CKHAPSEKAG YQICIETLEG TPFRQGVLER
60 70 80 90 100
SVEVSCQLRM TLFDSTYHHF FGRTWKSSTK PIKAIPGKAS KILFNEPIYF
110 120 130 140 150
YTTLIDPSIM AVIEVVALSK KQGGSKQELS CGFGIMSLFS HQLEDDSSIQ
160 170 180 190 200
SGRLKLYYGT PRSLLHPTLK DPNELNQHMT LIENTCIQYS VRPHKVLPTV
210 220 230 240 250
AHLFPENVLV SGSETIPGIM PSCDNSGDAL KKPHVQKTVI CYLDQICLFL
260 270 280 290 300
YPTLEKFEEE LTMLVNSDWL PKDDGNINGG SVSIQERRLH IGVHNGWVFV
310 320 330 340 350
QKPQIVVVVP EAEMMRGHST TSLKKKNIAQ QKLSSTVQAL VLRSRIRLPE
360 370 380 390 400
MVNHHGFALV FLLEYVFSIP NGIHSKTPSA ASSTSYMHMI RWASWTPSME
410 420 430 440 450
QGSADVALPL QGGPHHNPSN NLVYKMPPAN MSSEEVQQVE SGTVHFTFCA
460 470 480 490 500
GSENQLEKTR DFAETTSKEL IQSKKNVKMS NSKLVPETTF SPLESQVGPA
510 520 530 540 550
LSISQLTTSP RYPAISHSSK TAMQYIPSQL LPSPMAYQLS HAELPYASSI
560 570 580 590 600
THLEADMSES HPNNSNGEHL QELLFSPVHA PIVAMGTQTG STTSLLSRAS
610 620 630 640 650
LARLHSVEFP EILDCNNEVA EVVDPSNPVN FNLQREEADY LLCNEIVLQF
660 670 680 690 700
LAFTRIHDGS TIWPESIFFT FQFYRFHHVT TPRLQLLQLE SSDIATADPL
710 720 730 740 750
THVLVQINKD GSIKKGSPGF QIKYSVDPGF LKPGERKWFL RFLALQTLQI
760 770 780 790 800
DIWDGESLLL IGSAAVEMKH LLRQGRTAVQ VSHDLEVITT EYEQDLMVMS
810 820 830 840 850
GDTAKQGTAK PIGVHTIIKG RLHMRMGNVG RPPEKKLKRR ETLPPSNSRI
860 870 880 890 900
ITMHDGRTGF HGGSMLSNKS MNWKQSVCQA HKLADLDSEL AAMLCSRMKE
910 920 930 940 950
VSIAYQQTNS ETDTTERRKK ERMMAVRQQE SQENANLRKS LIMAQHEERT
960 970 980 990 1000
QHTRDLQIIE AYRERTKPEC ISSMLNQAIT SNYTVYATLG TAEFFEFELK
1010 1020 1030 1040 1050
NPYNIQYTVT IEIDSTDLRV ITDTREWKHF KELTSTVTPI EENMFHVQPN
1060 1070 1080 1090 1100
TVIPQLYLRA KETVYIPFKY QTFCVDHTPM LQGPDAESLR KHSQLSQYKS
1110 1120 1130 1140 1150
NAMSSRRIKV SFKTSDGKLI AILQVNIEPQ PHVVDQTFRF YHPELTFLKK
1160 1170 1180 1190 1200
SIRLPPWYTL PGAPVGTPGG EPDLQVRCSD INIICDSKKM GPGEPQDVFI
1210 1220 1230 1240 1250
KVAGGPSPQI KRFFIALYID PWLAAPIQIW QIYVHSLKRV DVSCITGQLT
1260 1270 1280 1290 1300
QLSLVLRGTQ VVRKVRAYSS HPEELKVDPD GVFVLPPNGI QDLHIGVRPQ
1310 1320 1330 1340 1350
KAGSQFIYLN LVDVDQHQLV ASWLVCVSCR KPVISKAFEI ALPVGGEKGC
1360 1370 1380 1390 1400
NKRISYRNPY PTKKTYSLYT NRSDLLQFKE NYFEVAAGET YSIGLRFAPS
1410 1420 1430
QTRGQEEILI FINDREDKNE ETFCVKVRYE
Length:1,430
Mass (Da):161,486
Last modified:November 2, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i472A687CD6EDC19A
GO

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

SMRiB0DOB4
ModBaseiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR029775, NPHP4
PANTHERiPTHR31043, PTHR31043, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNPHP4_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B0DOB4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2016
Last sequence update: November 2, 2016
Last modified: June 2, 2021
This is version 7 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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