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UniProtKB - B0CN39 (SFMM3_STRLA)
Protein
O-methyltransferase SfmM3
Gene
sfmM3
Organism
Streptomyces lavendulae
Status
Functioni
O-methyltransferase that mediates the methylation of 3-hydroxy-5-methyl-L-tyrosine (3-OH-5-Me-Tyr) into 3-hydroxy-5-methyl-O-methyltyrosine (3-OH-5-Me-OMe-Tyr), a core structure of saframycin A, a potent antitumor antibiotic that belongs to the tetrahydroisoquinoline family.
1 PublicationCatalytic activityi
: Antibiotic biosynthesis Pathwayi
This protein is involved in Antibiotic biosynthesis.1 PublicationView all proteins of this organism that are known to be involved in Antibiotic biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 190 | S-adenosyl-L-methioninePROSITE-ProRule annotation | 1 | |
Active sitei | 236 | Proton acceptorPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- O-methyltransferase activity Source: InterPro
GO - Biological processi
- antibiotic biosynthetic process Source: UniProtKB-KW
- methylation Source: UniProtKB-KW
Keywordsi
Molecular function | Methyltransferase, Transferase |
Biological process | Antibiotic biosynthesis |
Ligand | S-adenosyl-L-methionine |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:sfmM31 Publication |
Organismi | Streptomyces lavendulaeImported |
Taxonomic identifieri | 1914 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Streptomycetales › Streptomycetaceae › Streptomyces |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000430697 | 1 – 334 | O-methyltransferase SfmM3Add BLAST | 334 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 216 – 218 | S-adenosyl-L-methionine bindingPROSITE-ProRule annotation | 3 |
Sequence similaritiesi
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.PROSITE-ProRule annotation
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR016461, COMT-like IPR001077, O_MeTrfase_dom IPR029063, SAM-dependent_MTases IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR43712, PTHR43712, 1 hit |
Pfami | View protein in Pfam PF00891, Methyltransf_2, 1 hit |
PIRSFi | PIRSF005739, O-mtase, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF53335, SSF53335, 1 hit |
PROSITEi | View protein in PROSITE PS51683, SAM_OMT_II, 1 hit |
i Sequence
Sequence statusi: Complete.
B0CN39-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRRMLYAQLP SRALVVVAQL GIADILAEGP ADISTLAERT STDAVALARL
60 70 80 90 100
LRGLAVFGVF EEGAEQVYSL TPLGEALTSG HPASALPSAT LVAGQFGAAW
110 120 130 140 150
GDLLETVRTG QSPFERSRGV SLFTHMEQDE ELRAVFDDSQ GRGLALELDE
160 170 180 190 200
ILRAIDFSAY PTVVDVGGSD GTFLRRILSA HPDISGIVFD LPGSTSLQAE
210 220 230 240 250
RPTADPLEGR YSVATGDFFD SLPEGGDLYL LSHILHDWDD DRAVQILRTC
260 270 280 290 300
RAAMSDDATL MVVDLIAANR GQRDERLHTA ALMDLYMLSL FGGNGGQERT
310 320 330
AAQVEVLLSK AGFRITRVDS LPSGMNVIRA VRAA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ838002 Genomic DNA Translation: ABI22145.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ838002 Genomic DNA Translation: ABI22145.1 |
3D structure databases
SMRi | B0CN39 |
ModBasei | Search... |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR016461, COMT-like IPR001077, O_MeTrfase_dom IPR029063, SAM-dependent_MTases IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR43712, PTHR43712, 1 hit |
Pfami | View protein in Pfam PF00891, Methyltransf_2, 1 hit |
PIRSFi | PIRSF005739, O-mtase, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF53335, SSF53335, 1 hit |
PROSITEi | View protein in PROSITE PS51683, SAM_OMT_II, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SFMM3_STRLA | |
Accessioni | B0CN39Primary (citable) accession number: B0CN39 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 29, 2014 |
Last sequence update: | February 26, 2008 | |
Last modified: | February 23, 2022 | |
This is version 31 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families