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Protein

Inhibin alpha chain

Gene

INHA

Organism
Papio anubis (Olive baboon)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionGrowth factorUniRule annotationSAAS annotation, HormoneUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibin alpha chainUniRule annotation
Gene namesi
Name:INHAImported
OrganismiPapio anubis (Olive baboon)Imported
Taxonomic identifieri9555 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_500274685619 – 366Inhibin alpha chainSequence analysisAdd BLAST348

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini229 – 366TGF_BETA_2InterPro annotationAdd BLAST138

Sequence similaritiesi

Belongs to the TGF-beta family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

HOVERGENiHBG052131

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR017175 Inhibin_asu
IPR001839 TGF-b_C
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PTHR11848:SF117 PTHR11848:SF117, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PIRSFiPIRSF037328 Inhibin_alpha_subunit, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

B0CM57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLPLLLFLL LAPQGGHSCQ GPELARELVL AKVRALFLDA LGSPVVTREG
60 70 80 90 100
GDPGVRRLLR RHALGGFTRR GSEPEEEEDV SQAILFPATG ASCEDKPTAG
110 120 130 140 150
GLAQEAEEGL FTYMFRPSQH TRSRQVTSAH LWFHTGLDRQ GTAASNSSEP
160 170 180 190 200
LLGLLALSPA GPVAVPMSLG HAPPRWAVLH LATSALSLLT HPVLVLLLRC
210 220 230 240 250
PLCTWSAQPE ATPFLVAHTR TRPPSGGERA RRSTPPMSWP WSPSALRLLQ
260 270 280 290 300
RPAEEPAAHA NCHRVALNIS FQELGWERWI VYPPSFIFHY CHGGCGLHIP
310 320 330 340 350
PNLPLPVPGA PPTPAQPPSL LPGAQPCCAA LPGTMRPLHV RTTSDGGYSF
360
KYETVPNLLT QHCACI
Length:366
Mass (Da):39,464
Last modified:February 26, 2008 - v1
Checksum:i860D3E7A9D72535D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000550 Genomic DNA Translation: ABY67214.1
RefSeqiNP_001162490.1, NM_001169019.1
UniGeneiPan.18060

Genome annotation databases

GeneIDi100137490

Similar proteinsi

Entry informationi

Entry nameiB0CM57_PAPAN
AccessioniPrimary (citable) accession number: B0CM57
Entry historyiIntegrated into UniProtKB/TrEMBL: February 26, 2008
Last sequence update: February 26, 2008
Last modified: March 28, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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