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Protein

Bifunctional protein PyrR

Gene

pyrR

Organism
Actinobacillus pleuropneumoniae serotype 3 (strain JL03)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.UniRule annotation
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein PyrRUniRule annotation
Including the following 2 domains:
Pyrimidine operon regulatory proteinUniRule annotation
Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
Short name:
UPRTaseUniRule annotation
Gene namesi
Name:pyrRUniRule annotation
Ordered Locus Names:APJL_0422
OrganismiActinobacillus pleuropneumoniae serotype 3 (strain JL03)
Taxonomic identifieri434271 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
Proteomesi
  • UP000008547 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001391821 – 179Bifunctional protein PyrRAdd BLAST179

Structurei

3D structure databases

ProteinModelPortaliB0BTQ6
SMRiB0BTQ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi97 – 109PRPP-bindingUniRule annotationAdd BLAST13

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000245770
KOiK02825
OMAiRISHEIL
OrthoDBiPOG091H02JM

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01219 PyrR, 1 hit
InterProiView protein in InterPro
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR023050 PyrR
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit

Sequencei

Sequence statusi: Complete.

B0BTQ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKIIIDAEQ FQRTISRISH QIIEKHSSLD NLVLVGIKRR GAEIAEMLQS
60 70 80 90 100
RIAELAQTEL PLMALDITFY RDDLHLDHQD PVYTGVESQI DITGKNVILI
110 120 130 140 150
DDVLFTGRTI RAALDALLDF GRATRIELVI LVDRGHRELP IRADYVGKNI
160 170
PTARTEQVQV RTQFYDGMNQ VVLIRAKDE
Length:179
Mass (Da):20,417
Last modified:February 26, 2008 - v1
Checksum:i6F650880EA7905B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000687 Genomic DNA Translation: ABY69011.1
RefSeqiWP_005600504.1, NC_010278.1

Genome annotation databases

EnsemblBacteriaiABY69011; ABY69011; APJL_0422
GeneIDi4849058
KEGGiapj:APJL_0422

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000687 Genomic DNA Translation: ABY69011.1
RefSeqiWP_005600504.1, NC_010278.1

3D structure databases

ProteinModelPortaliB0BTQ6
SMRiB0BTQ6
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABY69011; ABY69011; APJL_0422
GeneIDi4849058
KEGGiapj:APJL_0422

Phylogenomic databases

HOGENOMiHOG000245770
KOiK02825
OMAiRISHEIL
OrthoDBiPOG091H02JM

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01219 PyrR, 1 hit
InterProiView protein in InterPro
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR023050 PyrR
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPYRR_ACTPJ
AccessioniPrimary (citable) accession number: B0BTQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 26, 2008
Last modified: November 7, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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