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Protein

ER membrane protein complex subunit 2

Gene

Emc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • protein folding in endoplasmic reticulum Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
ER membrane protein complex subunit 2
Alternative name(s):
Tetratricopeptide repeat protein 35
Short name:
TPR repeat protein 35
Gene namesi
Name:Emc2
Synonyms:Ttc35
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1310430 Emc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003337312 – 297ER membrane protein complex subunit 2Add BLAST296

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiB0BNG0
PeptideAtlasiB0BNG0
PRIDEiB0BNG0

Interactioni

Subunit structurei

Component of the ER membrane protein complex (EMC).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006890

Structurei

3D structure databases

ProteinModelPortaliB0BNG0
SMRiB0BNG0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati87 – 120TPR 1Add BLAST34
Repeati155 – 188TPR 2Add BLAST34
Repeati192 – 225TPR 3Add BLAST34

Sequence similaritiesi

Belongs to the EMC2 family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG3060 Eukaryota
ENOG410YT6B LUCA
HOGENOMiHOG000007547
HOVERGENiHBG055231
InParanoidiB0BNG0
PhylomeDBiB0BNG0
TreeFamiTF312997

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR039856 EMC2-like
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR12760 PTHR12760, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B0BNG0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKVTERYDV TWEEMRDKMR KWREENSRNS EQIMEVGEEL INDYASKLGD
60 70 80 90 100
DIWIIYEQVM IAALDYGRDD LALFCLQELR RQFPGSHRVK RLTGMRFEAM
110 120 130 140 150
ERYDDAIQLY DRILQEDPTN TAARKRKIAI RKAQGKNVEA IRELNEYLEQ
160 170 180 190 200
FVGDQEAWHE LAELYINEHD YAKAAFCLEE LMMTNPHNHL YCQQYAEVKY
210 220 230 240 250
TQGGLENLEL SRKYFAQALK LNNRNMRALF GLYMSASHIA SNPKASAKMK
260 270 280 290
KDNIRYAGWA ANQINRAYQF AGRSKKETKS SLKAVEDMLE TLQITQS
Length:297
Mass (Da):34,870
Last modified:February 26, 2008 - v1
Checksum:i7B8ABD95D4B8A849
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC158805 mRNA Translation: AAI58806.1
RefSeqiNP_001107257.1, NM_001113785.1
UniGeneiRn.203197

Genome annotation databases

GeneIDi362905
KEGGirno:362905
UCSCiRGD:1310430 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC158805 mRNA Translation: AAI58806.1
RefSeqiNP_001107257.1, NM_001113785.1
UniGeneiRn.203197

3D structure databases

ProteinModelPortaliB0BNG0
SMRiB0BNG0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006890

Proteomic databases

PaxDbiB0BNG0
PeptideAtlasiB0BNG0
PRIDEiB0BNG0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi362905
KEGGirno:362905
UCSCiRGD:1310430 rat

Organism-specific databases

CTDi9694
RGDi1310430 Emc2

Phylogenomic databases

eggNOGiKOG3060 Eukaryota
ENOG410YT6B LUCA
HOGENOMiHOG000007547
HOVERGENiHBG055231
InParanoidiB0BNG0
PhylomeDBiB0BNG0
TreeFamiTF312997

Miscellaneous databases

PROiPR:B0BNG0

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR039856 EMC2-like
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR12760 PTHR12760, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEMC2_RAT
AccessioniPrimary (citable) accession number: B0BNG0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 26, 2008
Last modified: November 7, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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