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UniProtKB - B0BNE5 (ESTD_RAT)
Protein
S-formylglutathione hydrolase
Gene
Esd
Organism
Rattus norvegicus (Rat)
Status
Functioni
Serine hydrolase involved in the detoxification of formaldehyde.
By similarityCatalytic activityi
- EC:3.1.2.12
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 149 | Charge relay systemBy similarity | 1 | |
Active sitei | 226 | Charge relay systemBy similarity | 1 | |
Active sitei | 260 | Charge relay systemBy similarity | 1 |
GO - Molecular functioni
- carboxylic ester hydrolase activity Source: UniProtKB-KW
- hydrolase activity, acting on ester bonds Source: RGD
- identical protein binding Source: RGD
- S-formylglutathione hydrolase activity Source: GO_Central
GO - Biological processi
- formaldehyde catabolic process Source: InterPro
Keywordsi
Molecular function | Hydrolase, Serine esterase |
Enzyme and pathway databases
Reactomei | R-RNO-156590, Glutathione conjugation |
Protein family/group databases
ESTHERi | rat-estd, A85-EsteraseD-FGH |
Names & Taxonomyi
Protein namesi | Recommended name: S-formylglutathione hydrolase (EC:3.1.2.12)Short name: FGH Alternative name(s): Esterase D |
Gene namesi | Name:Esd |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1592114, Esd |
Subcellular locationi
Cytoplasm and Cytosol
Other locations
- Cytoplasmic vesicle By similarity
Cytosol
- cytosol Source: GO_Central
Other locations
- cytoplasmic vesicle Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, Cytoplasmic vesiclePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000341966 | 1 – 282 | S-formylglutathione hydrolaseAdd BLAST | 282 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 4 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 200 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
jPOSTi | B0BNE5 |
PaxDbi | B0BNE5 |
PeptideAtlasi | B0BNE5 |
PRIDEi | B0BNE5 |
2D gel databases
World-2DPAGEi | 0004:B0BNE5 |
PTM databases
iPTMneti | B0BNE5 |
PhosphoSitePlusi | B0BNE5 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000009512, Expressed in kidney and 21 other tissues |
Genevisiblei | B0BNE5, RN |
Interactioni
Subunit structurei
Homodimer.
By similarityGO - Molecular functioni
- identical protein binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 253188, 1 interactor |
STRINGi | 10116.ENSRNOP00000013324 |
Family & Domainsi
Sequence similaritiesi
Belongs to the esterase D family.Curated
Phylogenomic databases
eggNOGi | KOG3101, Eukaryota |
GeneTreei | ENSGT00390000011864 |
HOGENOMi | CLU_056472_0_0_1 |
InParanoidi | B0BNE5 |
OMAi | TFMEDHL |
OrthoDBi | 942551at2759 |
PhylomeDBi | B0BNE5 |
TreeFami | TF300793 |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR000801, Esterase-like IPR014186, S-formylglutathione_hydrol |
PANTHERi | PTHR10061, PTHR10061, 1 hit |
Pfami | View protein in Pfam PF00756, Esterase, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
TIGRFAMsi | TIGR02821, fghA_ester_D, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
B0BNE5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MELKQISSNK CFGGLQKVFE HSSVELKCKM KFAIYLPPQA ESAKCPALYW
60 70 80 90 100
LSGLTCTEQN FISKSGCQQA ASEHGLVVIA PDTSPRGCNI KGEDDSWDFG
110 120 130 140 150
TGAGFFVNAT EDPWNTNYRM YSYVTEELPQ LINANFPVDP QRISIFGHSM
160 170 180 190 200
GGHGALICAL KNPGKYRSVS AFAPICNPVL CPWGKKAFNG YLGPDQSKWK
210 220 230 240 250
AYDATCLVKS YSGPQIDILI DQGKDDEFLS NGQLLPDNFI AACTEKKIPV
260 270 280
VFRLQEGYDH SYYFIATFIT DHIRHHAKYL NA
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A8I6A8R5 | A0A8I6A8R5_RAT | Esterase D/formylglutathione hydrol... | Esd Esd_mapped, rCG_37173 | 249 | Annotation score: | ||
A0A8I6A7Q6 | A0A8I6A7Q6_RAT | S-formylglutathione hydrolase | Esd | 259 | Annotation score: | ||
A0A8I6AWW9 | A0A8I6AWW9_RAT | S-formylglutathione hydrolase | Esd | 262 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC158790 mRNA Translation: AAI58791.1 |
RefSeqi | NP_001099521.1, NM_001106051.3 NP_001257794.1, NM_001270865.1 NP_001257795.1, NM_001270866.1 |
Genome annotation databases
Ensembli | ENSRNOT00000078013; ENSRNOP00000068608; ENSRNOG00000009512 |
GeneIDi | 290401 |
KEGGi | rno:290401 |
UCSCi | RGD:1592114, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC158790 mRNA Translation: AAI58791.1 |
RefSeqi | NP_001099521.1, NM_001106051.3 NP_001257794.1, NM_001270865.1 NP_001257795.1, NM_001270866.1 |
3D structure databases
AlphaFoldDBi | B0BNE5 |
SMRi | B0BNE5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 253188, 1 interactor |
STRINGi | 10116.ENSRNOP00000013324 |
Protein family/group databases
ESTHERi | rat-estd, A85-EsteraseD-FGH |
PTM databases
iPTMneti | B0BNE5 |
PhosphoSitePlusi | B0BNE5 |
2D gel databases
World-2DPAGEi | 0004:B0BNE5 |
Proteomic databases
jPOSTi | B0BNE5 |
PaxDbi | B0BNE5 |
PeptideAtlasi | B0BNE5 |
PRIDEi | B0BNE5 |
Genome annotation databases
Ensembli | ENSRNOT00000078013; ENSRNOP00000068608; ENSRNOG00000009512 |
GeneIDi | 290401 |
KEGGi | rno:290401 |
UCSCi | RGD:1592114, rat |
Organism-specific databases
CTDi | 2098 |
RGDi | 1592114, Esd |
Phylogenomic databases
eggNOGi | KOG3101, Eukaryota |
GeneTreei | ENSGT00390000011864 |
HOGENOMi | CLU_056472_0_0_1 |
InParanoidi | B0BNE5 |
OMAi | TFMEDHL |
OrthoDBi | 942551at2759 |
PhylomeDBi | B0BNE5 |
TreeFami | TF300793 |
Enzyme and pathway databases
Reactomei | R-RNO-156590, Glutathione conjugation |
Miscellaneous databases
PROi | PR:B0BNE5 |
Gene expression databases
Bgeei | ENSRNOG00000009512, Expressed in kidney and 21 other tissues |
Genevisiblei | B0BNE5, RN |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR000801, Esterase-like IPR014186, S-formylglutathione_hydrol |
PANTHERi | PTHR10061, PTHR10061, 1 hit |
Pfami | View protein in Pfam PF00756, Esterase, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
TIGRFAMsi | TIGR02821, fghA_ester_D, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ESTD_RAT | |
Accessioni | B0BNE5Primary (citable) accession number: B0BNE5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 2008 |
Last sequence update: | February 26, 2008 | |
Last modified: | May 25, 2022 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families