F-box only protein 5 (Predicted)

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• anaphase-promoting complex binding Source: RGDInferred from sequence orthologyⁱ
  • "Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor."
    Miller J.J., Summers M.K., Hansen D.V., Nachury M.V., Lehman N.L., Loktev A., Jackson P.K.
    Genes Dev. 20:2410-2420(2006) [PubMed] [Europe PMC] [Abstract]
  • "Atomic structure of the APC/C and its mechanism of protein ubiquitination."
    Chang L., Zhang Z., Yang J., McLaughlin S.H., Barford D.
    Nature 522:450-454(2015) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: RGDInferred from sequence orthologyⁱ
  • "Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome."
    Moshe Y., Boulaire J., Pagano M., Hershko A.
    Proc. Natl. Acad. Sci. U.S.A. 101:7937-7942(2004) [PubMed] [Europe PMC] [Abstract]
• ubiquitin ligase inhibitor activity Source: RGDInferred from sequence orthologyⁱ
  • "Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome."
    Moshe Y., Boulaire J., Pagano M., Hershko A.
    Proc. Natl. Acad. Sci. U.S.A. 101:7937-7942(2004) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• microtubule polymerization Source: RGDInferred from sequence orthologyⁱ
  • "Prophase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APC(Cdh1)."
    Marangos P., Verschuren E.W., Chen R., Jackson P.K., Carroll J.
    J. Cell Biol. 176:65-75(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cellular senescence Source: RGDInferred from sequence orthologyⁱ
  • "Loss of Emi1-dependent anaphase-promoting complex/cyclosome inhibition deregulates E2F target expression and elicits DNA damage-induced senescence."
    Verschuren E.W., Ban K.H., Masek M.A., Lehman N.L., Jackson P.K.
    Mol. Cell. Biol. 27:7955-7965(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of DNA endoreduplication Source: RGDInferred from sequence orthologyⁱ
  • "Loss of Emi1-dependent anaphase-promoting complex/cyclosome inhibition deregulates E2F target expression and elicits DNA damage-induced senescence."
    Verschuren E.W., Ban K.H., Masek M.A., Lehman N.L., Jackson P.K.
    Mol. Cell. Biol. 27:7955-7965(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of meiotic nuclear division Source: RGDInferred from sequence orthologyⁱ
  • "Functional interaction between p90Rsk2 and Emi1 contributes to the metaphase arrest of mouse oocytes."
    Paronetto M.P., Giorda E., Carsetti R., Rossi P., Geremia R., Sette C.
    EMBO J. 23:4649-4659(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of mitotic metaphase/anaphase transition Source: RGDInferred from sequence orthologyⁱ
  • "E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)."
    Hsu J.Y., Reimann J.D.R., Sorensen C.S., Lukas J., Jackson P.K.
    Nat. Cell Biol. 4:358-366(2002) [PubMed] [Europe PMC] [Abstract]
  • "Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor."
    Miller J.J., Summers M.K., Hansen D.V., Nachury M.V., Lehman N.L., Loktev A., Jackson P.K.
    Genes Dev. 20:2410-2420(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of response to DNA damage stimulus Source: RGDInferred from sequence orthologyⁱ
  • "Loss of Emi1-dependent anaphase-promoting complex/cyclosome inhibition deregulates E2F target expression and elicits DNA damage-induced senescence."
    Verschuren E.W., Ban K.H., Masek M.A., Lehman N.L., Jackson P.K.
    Mol. Cell. Biol. 27:7955-7965(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of ubiquitin protein ligase activity Source: RGDInferred from sequence orthologyⁱ
  • "E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)."
    Hsu J.Y., Reimann J.D.R., Sorensen C.S., Lukas J., Jackson P.K.
    Nat. Cell Biol. 4:358-366(2002) [PubMed] [Europe PMC] [Abstract]
  • "Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor."
    Miller J.J., Summers M.K., Hansen D.V., Nachury M.V., Lehman N.L., Loktev A., Jackson P.K.
    Genes Dev. 20:2410-2420(2006) [PubMed] [Europe PMC] [Abstract]
  • "Electron microscopy structure of human APC/C(CDH1)-EMI1 reveals multimodal mechanism of E3 ligase shutdown."
    Frye J.J., Brown N.G., Petzold G., Watson E.R., Grace C.R., Nourse A., Jarvis M.A., Kriwacki R.W., Peters J.M., Stark H., Schulman B.A.
    Nat. Struct. Mol. Biol. 20:827-835(2013) [PubMed] [Europe PMC] [Abstract]
  • "EMI1 switches from being a substrate to an inhibitor of APC/CCDH1 to start the cell cycle."
    Cappell S.D., Mark K.G., Garbett D., Pack L.R., Rape M., Meyer T.
    Nature 558:313-317(2018) [PubMed] [Europe PMC] [Abstract]
• negative regulation of ubiquitin-protein transferase activity Source: RGDInferred from sequence orthologyⁱ
  • "Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex."
    Wang W., Kirschner M.W.
    Nat. Cell Biol. 15:797-806(2013) [PubMed] [Europe PMC] [Abstract]
• oocyte maturation Source: RGDInferred from sequence orthologyⁱ
  • "Functional interaction between p90Rsk2 and Emi1 contributes to the metaphase arrest of mouse oocytes."
    Paronetto M.P., Giorda E., Carsetti R., Rossi P., Geremia R., Sette C.
    EMBO J. 23:4649-4659(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of biomineral tissue development Source: RGDInferred from sequence orthologyⁱ
  • "Two Transcripts of FBXO5 Promote Migration and Osteogenic Differentiation of Human Periodontal Ligament Mesenchymal Stem Cells."
    Liu L., Liu K., Yan Y., Chu Z., Tang Y., Tang C.
    Biomed. Res. Int. 2018:7849294-7849294(2018) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell population proliferation Source: RGDInferred from sequence orthologyⁱ
  • "The APC/C inhibitor, Emi1, is essential for prevention of rereplication."
    Machida Y.J., Dutta A.
    Genes Dev. 21:184-194(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of G2/M transition of mitotic cell cycle Source: RGDInferred from sequence orthologyⁱ
  • "Emi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/C."
    Di Fiore B., Pines J.
    J. Cell Biol. 177:425-437(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of mesenchymal stem cell migration Source: RGDInferred from sequence orthologyⁱ
  • "Two Transcripts of FBXO5 Promote Migration and Osteogenic Differentiation of Human Periodontal Ligament Mesenchymal Stem Cells."
    Liu L., Liu K., Yan Y., Chu Z., Tang Y., Tang C.
    Biomed. Res. Int. 2018:7849294-7849294(2018) [PubMed] [Europe PMC] [Abstract]
• positive regulation of osteoblast differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Two Transcripts of FBXO5 Promote Migration and Osteogenic Differentiation of Human Periodontal Ligament Mesenchymal Stem Cells."
    Liu L., Liu K., Yan Y., Chu Z., Tang Y., Tang C.
    Biomed. Res. Int. 2018:7849294-7849294(2018) [PubMed] [Europe PMC] [Abstract]
• regulation of DNA replication Source: RGDInferred from sequence orthologyⁱ
  • "The APC/C inhibitor, Emi1, is essential for prevention of rereplication."
    Machida Y.J., Dutta A.
    Genes Dev. 21:184-194(2007) [PubMed] [Europe PMC] [Abstract]
  • "Emi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/C."
    Di Fiore B., Pines J.
    J. Cell Biol. 177:425-437(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of meiotic nuclear division Source: RGDInferred from sequence orthologyⁱ
  • "Prophase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APC(Cdh1)."
    Marangos P., Verschuren E.W., Chen R., Jackson P.K., Carroll J.
    J. Cell Biol. 176:65-75(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of mitotic cell cycle Source: RGDInferred from sequence orthologyⁱ
  • "Mouse emi1 has an essential function in mitotic progression during early embryogenesis."
    Lee H., Lee D.J., Oh S.P., Park H.D., Nam H.H., Kim J.M., Lim D.-S.
    Mol. Cell. Biol. 26:5373-5381(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of mitotic nuclear division Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• spindle assembly Source: RGDInferred from sequence orthologyⁱ
  • "Prophase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APC(Cdh1)."
    Marangos P., Verschuren E.W., Chen R., Jackson P.K., Carroll J.
    J. Cell Biol. 176:65-75(2007) [PubMed] [Europe PMC] [Abstract]
• spindle assembly involved in female meiosis I Source: RGDInferred from sequence orthologyⁱ
  • "Prophase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APC(Cdh1)."
    Marangos P., Verschuren E.W., Chen R., Jackson P.K., Carroll J.
    J. Cell Biol. 176:65-75(2007) [PubMed] [Europe PMC] [Abstract]
• vesicle organization Source: RGDInferred from sequence orthologyⁱ
  • "Prophase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APC(Cdh1)."
    Marangos P., Verschuren E.W., Chen R., Jackson P.K., Carroll J.
    J. Cell Biol. 176:65-75(2007) [PubMed] [Europe PMC] [Abstract]

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• protein kinase binding Source: RGDInferred from sequence orthologyⁱ
  • "Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome."
    Moshe Y., Boulaire J., Pagano M., Hershko A.
    Proc. Natl. Acad. Sci. U.S.A. 101:7937-7942(2004) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSRRACGDLP RPSSCLCPLD ARTTVDGCKE ESPVLSVTMK CFNCNPDLLE 
        60         70         80         90        100
LEVVKTEDSG REGSYSPVCL EPSCDNCVGN HERLSFVESP IVGHDNKENQ 
       110        120        130        140        150
RVQNILDSSK EVEELEASRL YEDSGYSSFI QSDSDDGILI LENFRNSSQA 
       160        170        180        190        200
HLLLSSQSPD QHPNKNLLPA LHFERVVCST LKKNGKRNSK VDQEMLKEVI 
       210        220        230        240        250
ASGNITLQNI IGKKMGLEHL DILAELSRRG CMHLLANIFM KLSGMDLINL 
       260        270        280        290        300
SKVSRIWKKI LESDKGAFQQ YSKAMQRVIE SNKLSLHAST RGYVVGRTAL 
       310        320        330        340        350
TCVQKSSTWA PPKNVQPSQR GQRGSVYSRH NEFLEVAKTL KNNESLKACV 
       360        370        380        390        400
RCNFPAKYDH YLERAVCKRE SCKFEYCTKC LCAYHNNKDC LNSKNLKASC 
       410 
KMGPLPGTKK SKKNLQRL                                    

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ