UniProtKB - B0BNA4 (B0BNA4_RAT)
Protein
Submitted name:
F-box only protein 5 (Predicted)
Gene
Fbxo5
Organism
Rattus norvegicus (Rat)
Status
Functioni
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.ARBA annotationView all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Molecular functioni
- anaphase-promoting complex binding Source: RGD
- protein kinase binding Source: RGD
- ubiquitin ligase inhibitor activity Source: RGD
GO - Biological processi
- microtubule polymerization Source: RGD
- negative regulation of cellular senescence Source: RGD
- negative regulation of DNA endoreduplication Source: RGD
- negative regulation of meiotic nuclear division Source: RGD
- negative regulation of mitotic metaphase/anaphase transition Source: RGD
- negative regulation of response to DNA damage stimulus Source: RGD
- negative regulation of ubiquitin protein ligase activity Source: RGD
- negative regulation of ubiquitin-protein transferase activity Source: RGD
- oocyte maturation Source: RGD
- positive regulation of biomineral tissue development Source: RGD
- positive regulation of cell population proliferation Source: RGD
- positive regulation of G2/M transition of mitotic cell cycle Source: RGD
- positive regulation of mesenchymal stem cell migration Source: RGD
- positive regulation of osteoblast differentiation Source: RGD
- regulation of DNA replication Source: RGD
- regulation of meiotic nuclear division Source: RGD
- regulation of mitotic cell cycle Source: RGD
- regulation of mitotic nuclear division Source: GO_Central
- spindle assembly Source: RGD
- spindle assembly involved in female meiosis I Source: RGD
- vesicle organization Source: RGD
Keywordsi
Biological process | Cell cycle, Cell division, MitosisARBA annotation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-RNO-176408, Regulation of APC/C activators between G1/S and early anaphase R-RNO-176417, Phosphorylation of Emi1 R-RNO-68881, Mitotic Metaphase/Anaphase Transition |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Submitted name: F-box only protein 5 (Predicted)ImportedSubmitted name: F-box protein 5Imported |
Gene namesi | ORF Names:rCG_41116Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1309405, Fbxo5 |
Subcellular locationi
Cytoskeleton
- meiotic spindle Source: RGD
- spindle Source: RGD
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: RGD
Other locations
- cytoplasm Source: RGD
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000024077, Expressed in thymus and 21 other tissues |
Interactioni
GO - Molecular functioni
- protein kinase binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000034853 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 345 – 393 | ZBR-typeInterPro annotationAdd BLAST | 49 |
Keywords - Domaini
Zinc-fingerPROSITE-ProRule annotationPhylogenomic databases
eggNOGi | ENOG502QPWN, Eukaryota |
GeneTreei | ENSGT00530000063692 |
HOGENOMi | CLU_055946_0_0_1 |
OMAi | IKFSPHA |
OrthoDBi | 521317at2759 |
TreeFami | TF101170 |
Family and domain databases
InterProi | View protein in InterPro IPR036047, F-box-like_dom_sf IPR001810, F-box_dom IPR044064, ZF_ZBR |
Pfami | View protein in Pfam PF00646, F-box, 1 hit |
SUPFAMi | SSF81383, SSF81383, 1 hit |
PROSITEi | View protein in PROSITE PS51872, ZF_ZBR, 1 hit |
i Sequence
Sequence statusi: Complete.
B0BNA4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRRACGDLP RPSSCLCPLD ARTTVDGCKE ESPVLSVTMK CFNCNPDLLE
60 70 80 90 100
LEVVKTEDSG REGSYSPVCL EPSCDNCVGN HERLSFVESP IVGHDNKENQ
110 120 130 140 150
RVQNILDSSK EVEELEASRL YEDSGYSSFI QSDSDDGILI LENFRNSSQA
160 170 180 190 200
HLLLSSQSPD QHPNKNLLPA LHFERVVCST LKKNGKRNSK VDQEMLKEVI
210 220 230 240 250
ASGNITLQNI IGKKMGLEHL DILAELSRRG CMHLLANIFM KLSGMDLINL
260 270 280 290 300
SKVSRIWKKI LESDKGAFQQ YSKAMQRVIE SNKLSLHAST RGYVVGRTAL
310 320 330 340 350
TCVQKSSTWA PPKNVQPSQR GQRGSVYSRH NEFLEVAKTL KNNESLKACV
360 370 380 390 400
RCNFPAKYDH YLERAVCKRE SCKFEYCTKC LCAYHNNKDC LNSKNLKASC
410
KMGPLPGTKK SKKNLQRL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07001406 Genomic DNA No translation available. BC158745 mRNA Translation: AAI58746.1 CH474052 Genomic DNA Translation: EDL92840.1 |
RefSeqi | NP_001099676.1, NM_001106206.1 |
Genome annotation databases
Ensembli | ENSRNOT00000029416; ENSRNOP00000034853; ENSRNOG00000024077 |
GeneIDi | 292263 |
KEGGi | rno:292263 |
UCSCi | RGD:1309405, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07001406 Genomic DNA No translation available. BC158745 mRNA Translation: AAI58746.1 CH474052 Genomic DNA Translation: EDL92840.1 |
RefSeqi | NP_001099676.1, NM_001106206.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000034853 |
Genome annotation databases
Ensembli | ENSRNOT00000029416; ENSRNOP00000034853; ENSRNOG00000024077 |
GeneIDi | 292263 |
KEGGi | rno:292263 |
UCSCi | RGD:1309405, rat |
Organism-specific databases
CTDi | 26271 |
RGDi | 1309405, Fbxo5 |
Phylogenomic databases
eggNOGi | ENOG502QPWN, Eukaryota |
GeneTreei | ENSGT00530000063692 |
HOGENOMi | CLU_055946_0_0_1 |
OMAi | IKFSPHA |
OrthoDBi | 521317at2759 |
TreeFami | TF101170 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Reactomei | R-RNO-176408, Regulation of APC/C activators between G1/S and early anaphase R-RNO-176417, Phosphorylation of Emi1 R-RNO-68881, Mitotic Metaphase/Anaphase Transition |
Gene expression databases
Bgeei | ENSRNOG00000024077, Expressed in thymus and 21 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR036047, F-box-like_dom_sf IPR001810, F-box_dom IPR044064, ZF_ZBR |
Pfami | View protein in Pfam PF00646, F-box, 1 hit |
SUPFAMi | SSF81383, SSF81383, 1 hit |
PROSITEi | View protein in PROSITE PS51872, ZF_ZBR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B0BNA4_RAT | |
Accessioni | B0BNA4Primary (citable) accession number: B0BNA4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 26, 2008 |
Last sequence update: | February 26, 2008 | |
Last modified: | December 2, 2020 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |