UniProtKB - B0BL08 (B0BL08_ECOLX)
Protein
Dihydrofolate reductase
Gene
dfrA17
Organism
Escherichia coli
Status
Functioni
: tetrahydrofolate biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate.ARBA annotationProteins known to be involved in this subpathway in this organism are:
- Dihydrofolate reductase (dfrA17), Dihydrofolate reductase (dhfrIb), Dihydrofolate reductase type A10 (dfrA10), Dihydrofolate reductase (dfrA15), Dihydrofolate reductase (dfrV), Dihydrofolate reductase (G5603_17475), Dihydrofolate reductase (dhfr17), Dihydrofolate reductase, Dihydrofolate reductase (folA), Dihydrofolate reductase (folA), Dihydrofolate reductase (dfrA12), Dihydrofolate reductase (HLU20_15395), Dihydrofolate reductase (GNZ05_04555), Dihydrofolate reductase (folA), Dihydrofolate reductase (folA), Dihydrofolate reductase (dfrA1), Dihydrofolate reductase (folA), Dihydrofolate reductase (F7F11_16600), Dihydrofolate reductase (dhfr14), Dihydrofolate reductase (dhfrVII), Dihydrofolate reductase (dhfr17), Dihydrofolate reductase (dfrA7), Dihydrofolate reductase (dhfrV), Dihydrofolate reductase (folA), Dihydrofolate reductase (dfrA), Dihydrofolate reductase (dfrA17), Dihydrofolate reductase (folA), Dihydrofolate reductase (folA), Dihydrofolate reductase (dfrA), Dihydrofolate reductase (folA), Dihydrofolate reductase (folA), Dihydrofolate reductase (dfrA12), Dihydrofolate reductase (dfrA12), Dihydrofolate reductase (dhfrI), Dihydrofolate reductase (dfrA), Dihydrofolate reductase (folA), Dihydrofolate reductase (folA), Dihydrofolate reductase (folA), Dihydrofolate reductase (dhfrXIII), Dihydrofolate reductase type 2, Dihydrofolate reductase (CSB64_27845), Dihydrofolate reductase (dfrA17), Dihydrofolate reductase (folA_1), Dihydrofolate reductase (HL359_23655), Dihydrofolate reductase (dfrA15), Dihydrofolate reductase (dfrA17), Dihydrofolate reductase (folA), Dihydrofolate reductase (dfrA17), Dihydrofolate reductase (HHB19_005188), Dihydrofolate reductase (DHFR), Dihydrofolate reductase (HMU02_25090), Dihydrofolate reductase (dfrA), Dihydrofolate reductase (dfrA14), Dihydrofolate reductase (folA), Dihydrofolate reductase (dfrA17), Dihydrofolate reductase (folA), Dihydrofolate reductase (folA_2), Dihydrofolate reductase (folA), Dihydrofolate reductase (folA), Dihydrofolate reductase (EXX87_23245), Dihydrofolate reductase (dfrA12), Dihydrofolate reductase (GE513_25810), Dihydrofolate reductase (folA), Dihydrofolate reductase (folA), Dihydrofolate reductase (dhfr17), Dihydrofolate reductase (HL375_24075), Dihydrofolate reductase (dfrA1), Dihydrofolate reductase (dfrA17), Dihydrofolate reductase type 8 (dhfrVIII), Dihydrofolate reductase type 9 (dhfrIX), Dihydrofolate reductase (dfr17), Dihydrofolate reductase (folA), Dihydrofolate reductase, Dihydrofolate reductase (dfrA1), Dihydrofolate reductase (EAI46_08460), Dihydrofolate reductase (dfrA17), Dihydrofolate reductase (dhfr), Dihydrofolate reductase (GE496_21165), Dihydrofolate reductase (dfrA12), Dihydrofolate reductase (dfrA17), Dihydrofolate reductase (dfrA1), Dihydrofolate reductase (folA), Dihydrofolate reductase (folA), Dihydrofolate reductase (dfrA), Dihydrofolate reductase (dfrA21), Dihydrofolate reductase (folA), Dihydrofolate reductase (BON98_23805), Dihydrofolate reductase (folA_1), Dihydrofolate reductase (dfrA12), Dihydrofolate reductase (dhfrI), Dihydrofolate reductase (dfrA), Dihydrofolate reductase (dfrA10), Dihydrofolate reductase type 15 (dhfrXV), Dihydrofolate reductase (HIZ86_003783), Dihydrofolate reductase (GIJ78_18025), Dihydrofolate reductase (dfrII), Dihydrofolate reductase (dhfrIb), Dihydrofolate reductase (BW690_27660), Dihydrofolate reductase (folA), Dihydrofolate reductase, Dihydrofolate reductase (folA), Dihydrofolate reductase (HMJ79_003998), Dihydrofolate reductase (CI641_024860), Dihydrofolate reductase, Dihydrofolate reductase (folA), Dihydrofolate reductase (folA), Dihydrofolate reductase (folA), Dihydrofolate reductase (HML99_08790), Dihydrofolate reductase (dfrA8), Dihydrofolate reductase (dfrA12), Dihydrofolate reductase (folA), Dihydrofolate reductase (dfrA17), Dihydrofolate reductase (folA), Dihydrofolate reductase (GRW81_30990), Dihydrofolate reductase (folA), Dihydrofolate reductase (folA), Dihydrofolate reductase (dfrA12), Dihydrofolate reductase (G6842_00005), Dihydrofolate reductase (dfrA14), Dihydrofolate reductase (dfrA14), Dihydrofolate reductase (dhfrVII), Dihydrofolate reductase (folA_2), Dihydrofolate reductase (HIC10_004063), Dihydrofolate reductase (folA), Dihydrofolate reductase (dfrA1), Dihydrofolate reductase (dfrA17), Dihydrofolate reductase (EAN77_10050), Dihydrofolate reductase (dfrA17), Dihydrofolate reductase (folA), Dihydrofolate reductase, Dihydrofolate reductase (dfrB2), Dihydrofolate reductase (dfrA17), Dihydrofolate reductase (HML69_25275), Dihydrofolate reductase (dfrA7), Dihydrofolate reductase (EIA08_31410), Dihydrofolate reductase (folA), Dihydrofolate reductase (C6985_00430), Dihydrofolate reductase (folA), Dihydrofolate reductase, Dihydrofolate reductase (folA), Dihydrofolate reductase (dfrA17), Dihydrofolate reductase (E5P28_23870), Dihydrofolate reductase (dfrA17), Dihydrofolate reductase (folA), Dihydrofolate reductase (HMV62_23775), Dihydrofolate reductase type 2, Dihydrofolate reductase (HMPREF3040_00012), Dihydrofolate reductase (dfrB3), Dihydrofolate reductase (G3565_04440), Dihydrofolate reductase type 2, Dihydrofolate reductase (dfrA17), Dihydrofolate reductase type 1 (dhfrI), Dihydrofolate reductase (dfr6), Dihydrofolate reductase (dfrA17), Dihydrofolate reductase (folA), Dihydrofolate reductase type 5 (dhfrV), Dihydrofolate reductase (dfr16), Dihydrofolate reductase (dfrA12), Dihydrofolate reductase (GE517_26895), Dihydrofolate reductase (folA), Dihydrofolate reductase (folA), Dihydrofolate reductase (dfr VII), Dihydrofolate reductase (dfrA1), Dihydrofolate reductase (dfrA7), Dihydrofolate reductase (dfrD), Dihydrofolate reductase (dfrA1), Dihydrofolate reductase (dfrA5), Dihydrofolate reductase (BHS87_26495), Dihydrofolate reductase (dhfr17), Dihydrofolate reductase (dfrA14), Dihydrofolate reductase (folA), Dihydrofolate reductase (ECs0051), Dihydrofolate reductase (dfrA17), Dihydrofolate reductase (dfrA), Dihydrofolate reductase (plasmid_0174), Dihydrofolate reductase (dfrA26), Dihydrofolate reductase (dfrA12), Dihydrofolate reductase (dfrA1), Dihydrofolate reductase (HHB19_005044), Dihydrofolate reductase (dfrA17), Dihydrofolate reductase (HJT74_004398), Dihydrofolate reductase (ELU96_18835), Dihydrofolate reductase (folA), Dihydrofolate reductase (dfrA), Dihydrofolate reductase (GKF86_26395), Dihydrofolate reductase (dfrA17), Dihydrofolate reductase (dfrA12), Dihydrofolate reductase (dfrA), Dihydrofolate reductase (HIZ50_004031), Dihydrofolate reductase type A13 (dfrA13), Dihydrofolate reductase (folA), Dihydrofolate reductase (dfrA), Dihydrofolate reductase (dfrA), Dihydrofolate reductase (dfrA14), Dihydrofolate reductase (dfr17a), Dihydrofolate reductase (dfrA17), Dihydrofolate reductase, Dihydrofolate reductase (GKF39_25930), Dihydrofolate reductase (dfr22), Dihydrofolate reductase (D0368_00288), Dihydrofolate reductase (folA), Dihydrofolate reductase (EO241_29310), Dihydrofolate reductase (folA), Dihydrofolate reductase (folA), Dihydrofolate reductase (folA), Dihydrofolate reductase (folA), Dihydrofolate reductase, Dihydrofolate reductase (dfrA12), Dihydrofolate reductase (dhfrV), Dihydrofolate reductase, Dihydrofolate reductase (dfr22), Dihydrofolate reductase (D0368_00180), Dihydrofolate reductase (dfrA14), Dihydrofolate reductase (dfrA24), Dihydrofolate reductase (HNC40_17160), Dihydrofolate reductase (dfr1), Dihydrofolate reductase, Dihydrofolate reductase (dfrA), Dihydrofolate reductase (ELX70_21350), Dihydrofolate reductase (dfrA), Dihydrofolate reductase (BTQ06_28630), Dihydrofolate reductase (dhfrVII), Dihydrofolate reductase (dfrA36), Dihydrofolate reductase (delta dfrA17), Dihydrofolate reductase (dfr16), Dihydrofolate reductase (dfrA), Dihydrofolate reductase (dfrA29), Dihydrofolate reductase (HIB18_004207), Dihydrofolate reductase (DfrA17), Dihydrofolate reductase (dfrI), Dihydrofolate reductase (dhfrI), Dihydrofolate reductase (CQB02_18430), Dihydrofolate reductase (dfrA1), Dihydrofolate reductase (dfr2d), Dihydrofolate reductase (D9F05_04510), Dihydrofolate reductase (dfr17), Dihydrofolate reductase (dfrD), Dihydrofolate reductase (folA), Dihydrofolate reductase (GF684_10590), Dihydrofolate reductase (folA), Dihydrofolate reductase (folA), Dihydrofolate reductase, Dihydrofolate reductase (HHB19_003248), Dihydrofolate reductase (folA), Dihydrofolate reductase (folA), Dihydrofolate reductase (DS143_29305), Dihydrofolate reductase (dhfr1), Dihydrofolate reductase (dfrA1), Dihydrofolate reductase (dfrA7), Dihydrofolate reductase (dfrA), Dihydrofolate reductase (dfrA17), Dihydrofolate reductase (D9J03_00795), Dihydrofolate reductase (dfrA17), Dihydrofolate reductase (dfrA27), Dihydrofolate reductase (HGS67_25140), Dihydrofolate reductase (folA), Dihydrofolate reductase (folA), Dihydrofolate reductase (dhfr1), Dihydrofolate reductase (folA), Dihydrofolate reductase (dfr2d), Dihydrofolate reductase (dfrA1), Dihydrofolate reductase (dfrA17), Dihydrofolate reductase (HJT81_003889), Dihydrofolate reductase (folA), Dihydrofolate reductase (dhfrI_1), Dihydrofolate reductase (dfrA17), Dihydrofolate reductase (dfrAI), Dihydrofolate reductase (folA), Dihydrofolate reductase (C9E25_17285), Dihydrofolate reductase (dfrA7), Dihydrofolate reductase (dfrA), Dihydrofolate reductase (dfr2a), Dihydrofolate reductase (folA), Dihydrofolate reductase (dfrI), Dihydrofolate reductase type 7 (dhfrVII), Dihydrofolate reductase (folA), Dihydrofolate reductase (dfrA7), Dihydrofolate reductase (dfrA12), Dihydrofolate reductase (folA), Dihydrofolate reductase (dfrA12), Dihydrofolate reductase (dfrA17), Dihydrofolate reductase (folA), Dihydrofolate reductase (dfrA3b), Dihydrofolate reductase (dfrA17), Dihydrofolate reductase (folA_2), Dihydrofolate reductase (dfr1)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.
GO - Molecular functioni
- dihydrofolate reductase activity Source: UniProtKB-EC
- NADP binding Source: InterPro
GO - Biological processi
- glycine biosynthetic process Source: InterPro
- tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | OxidoreductaseARBA annotation |
Ligand | NADPARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00077;UER00158 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:dfrA17Imported |
Organismi | Escherichia coliImported |
Taxonomic identifieri | 562 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 156 | DHFRInterPro annotationAdd BLAST | 155 |
Sequence similaritiesi
Family and domain databases
CDDi | cd00209, DHFR, 1 hit |
Gene3Di | 3.40.430.10, 1 hit |
InterProi | View protein in InterPro IPR012259, DHFR IPR024072, DHFR-like_dom_sf IPR017925, DHFR_CS IPR001796, DHFR_dom |
PANTHERi | PTHR48069, PTHR48069, 1 hit |
Pfami | View protein in Pfam PF00186, DHFR_1, 1 hit |
SUPFAMi | SSF53597, SSF53597, 1 hit |
PROSITEi | View protein in PROSITE PS00075, DHFR_1, 1 hit PS51330, DHFR_2, 1 hit |
i Sequence
Sequence statusi: Complete.
B0BL08-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKISLISAVS ESGVIGSGPD IPWSVKGEQL LFKALTYNQW LLVGRKTFDS
60 70 80 90 100
MGVLPNRKYA VVSKNGISSS NENVLVFPSI ENALKELSKV TDHVYVSGGG
110 120 130 140 150
QIYNSLIEKA DIIHLSTVHV EVEGDIKFPI MPENFNLVFE QFFMSNINYT
YQIWKKG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM932673 Genomic DNA Translation: CAP69686.1 |
RefSeqi | WP_063844367.1, NG_047711.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM932673 Genomic DNA Translation: CAP69686.1 |
RefSeqi | WP_063844367.1, NG_047711.1 |
3D structure databases
SMRi | B0BL08 |
ModBasei | Search... |
Chemistry databases
BindingDBi | B0BL08 |
ChEMBLi | CHEMBL5441 |
DrugCentrali | B0BL08 |
Enzyme and pathway databases
UniPathwayi | UPA00077;UER00158 |
Family and domain databases
CDDi | cd00209, DHFR, 1 hit |
Gene3Di | 3.40.430.10, 1 hit |
InterProi | View protein in InterPro IPR012259, DHFR IPR024072, DHFR-like_dom_sf IPR017925, DHFR_CS IPR001796, DHFR_dom |
PANTHERi | PTHR48069, PTHR48069, 1 hit |
Pfami | View protein in Pfam PF00186, DHFR_1, 1 hit |
SUPFAMi | SSF53597, SSF53597, 1 hit |
PROSITEi | View protein in PROSITE PS00075, DHFR_1, 1 hit PS51330, DHFR_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B0BL08_ECOLX | |
Accessioni | B0BL08Primary (citable) accession number: B0BL08 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 26, 2008 |
Last sequence update: | February 26, 2008 | |
Last modified: | April 7, 2021 | |
This is version 47 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |