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Protein

LL-diaminopimelate aminotransferase

Gene

dapL

Organism
Chlamydia trachomatis serovar L2b (strain UCH-1/proctitis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. LL-diaminopimelate aminotransferase (dapL)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route), the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei14SubstrateUniRule annotation1
Binding sitei41Substrate; via amide nitrogenUniRule annotation1
Binding sitei71Pyridoxal phosphateUniRule annotation1
Binding sitei105SubstrateUniRule annotation1
Binding sitei128Pyridoxal phosphateUniRule annotation1
Binding sitei128SubstrateUniRule annotation1
Binding sitei174Pyridoxal phosphateUniRule annotation1
Binding sitei174SubstrateUniRule annotation1
Binding sitei205Pyridoxal phosphateUniRule annotation1
Binding sitei244Pyridoxal phosphateUniRule annotation1
Binding sitei275Pyridoxal phosphateUniRule annotation1
Binding sitei275SubstrateUniRule annotation1
Binding sitei369SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayi
UPA00034;UER00466

Names & Taxonomyi

Protein namesi
Recommended name:
LL-diaminopimelate aminotransferaseUniRule annotation (EC:2.6.1.83UniRule annotation)
Short name:
DAP-ATUniRule annotation
Short name:
DAP-aminotransferaseUniRule annotation
Short name:
LL-DAP-aminotransferaseUniRule annotation
Gene namesi
Name:dapLUniRule annotation
Ordered Locus Names:CTLon_0643
OrganismiChlamydia trachomatis serovar L2b (strain UCH-1/proctitis)
Taxonomic identifieri471473 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003422221 – 394LL-diaminopimelate aminotransferaseAdd BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei236N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB0BC25
SMRiB0BC25
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni104 – 105Pyridoxal phosphate bindingUniRule annotation2
Regioni233 – 235Pyridoxal phosphate bindingUniRule annotation3

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000223061
KOiK10206
OMAiTGTRCAF

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01642 DapL_aminotrans_1, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR019942 DapL/ALD1
IPR004838 NHTrfase_class1_PyrdxlP-BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR43144 PTHR43144, 1 hit
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR03542 DAPAT_plant, 1 hit
PROSITEiView protein in PROSITE
PS00105 AA_TRANSFER_CLASS_1, 1 hit

Sequencei

Sequence statusi: Complete.

B0BC25-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRNPHFVSL TKNYLFADLQ KRVAQFRLEN PQHTVINLSI GDTTQPLNAS
60 70 80 90 100
VAEAFASSIA RLSSPTTCRG YGPDFGLPAL RQKLSEDFYR GCVDAKEIFI
110 120 130 140 150
SDGAKADLFR LLSFFGPNQT VAIQDPSYPA YLDIARLTGA KEIIALPCLQ
160 170 180 190 200
ENAFFPEFPE DTHIDILCLC SPNNPTGTVL NKDQLRAIVH YAIEHEILIL
210 220 230 240 250
FDAAYSTFIS DPSLPKSIFE IPDARFCAIE INSFSKPLGF AGIRLGWTVI
260 270 280 290 300
PQELTYADGH FVIQDWERFL STTFNGASIP AQEAGVAGLS ILPQLEAIHY
310 320 330 340 350
YRENSDLLRK ALLATGFEVF GGEHAPYLWV KPTQANISDR DLFDFFLREY
360 370 380 390
HIAITPGIGF GRSGSGFVRF SSLGKREDIL AACERLQMAP ALQS
Length:394
Mass (Da):43,769
Last modified:February 26, 2008 - v1
Checksum:iE944E25E0D4F8A94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM884177 Genomic DNA Translation: CAP07040.1
RefSeqiWP_009873777.1, NC_010280.2

Genome annotation databases

EnsemblBacteriaiCAP07040; CAP07040; CTLon_0643
KEGGictl:CTLon_0643

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM884177 Genomic DNA Translation: CAP07040.1
RefSeqiWP_009873777.1, NC_010280.2

3D structure databases

ProteinModelPortaliB0BC25
SMRiB0BC25
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAP07040; CAP07040; CTLon_0643
KEGGictl:CTLon_0643

Phylogenomic databases

HOGENOMiHOG000223061
KOiK10206
OMAiTGTRCAF

Enzyme and pathway databases

UniPathwayi
UPA00034;UER00466

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01642 DapL_aminotrans_1, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR019942 DapL/ALD1
IPR004838 NHTrfase_class1_PyrdxlP-BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR43144 PTHR43144, 1 hit
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR03542 DAPAT_plant, 1 hit
PROSITEiView protein in PROSITE
PS00105 AA_TRANSFER_CLASS_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDAPAT_CHLTB
AccessioniPrimary (citable) accession number: B0BC25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: February 26, 2008
Last modified: October 10, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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