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Protein

Ribonuclease 3

Gene

rnc

Organism
Chlamydia trachomatis serovar L2b (strain UCH-1/proctitis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi48MagnesiumUniRule annotation1
Active sitei52UniRule annotation1
Metal bindingi121MagnesiumUniRule annotation1
Active sitei124UniRule annotation1
Metal bindingi124MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease, RNA-binding, rRNA-binding
Biological processmRNA processing, rRNA processing, tRNA processing
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
Alternative name(s):
Ribonuclease IIIUniRule annotation
Short name:
RNase IIIUniRule annotation
Gene namesi
Name:rncUniRule annotation
Ordered Locus Names:CTLon_0545
OrganismiChlamydia trachomatis serovar L2b (strain UCH-1/proctitis)
Taxonomic identifieri471473 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000941001 – 231Ribonuclease 3Add BLAST231

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB0BBS8
SMRiB0BBS8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 135RNase IIIUniRule annotationAdd BLAST129
Domaini160 – 229DRBMUniRule annotationAdd BLAST70

Sequence similaritiesi

Belongs to the ribonuclease III family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000246808
KOiK03685
OMAiLTHKSCK

Family and domain databases

CDDicd00048 DSRM, 1 hit
cd00593 RIBOc, 1 hit
Gene3Di1.10.1520.10, 1 hit
HAMAPiMF_00104 RNase_III, 1 hit
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR011907 RNase_III
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF00035 dsrm, 1 hit
PF14622 Ribonucleas_3_3, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 1 hit
SM00535 RIBOc, 1 hit
SUPFAMiSSF69065 SSF69065, 1 hit
TIGRFAMsiTIGR02191 RNaseIII, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 1 hit

Sequencei

Sequence statusi: Complete.

B0BBS8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQHTVDIQAI ESKLNFTFSH PRLLITALTH SSYRNEFPSA EEDSERLEFL
60 70 80 90 100
GDAVLGLVVT EHLFLLFPAL NEGLLSTTRA ALVNAEACFE YTQKLSLGEH
110 120 130 140 150
LLIGRGEKMQ SHRGKISAYA NLFEAILGAV YLDGGLSPAR QIIVPLLPDK
160 170 180 190 200
ESILPLMLVN PKNRLQQFTQ QTLKVLPSYK ALPWKSEDGS PGYHVQVFVN
210 220 230
GDLWGEGFAG SKKEAEKLAA KQALSTHDNK N
Length:231
Mass (Da):25,585
Last modified:February 26, 2008 - v1
Checksum:i26F75D4127B24369
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM884177 Genomic DNA Translation: CAP06943.1
RefSeqiWP_012263635.1, NC_010280.2

Genome annotation databases

EnsemblBacteriaiCAP06943; CAP06943; CTLon_0545
KEGGictl:CTLon_0545

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM884177 Genomic DNA Translation: CAP06943.1
RefSeqiWP_012263635.1, NC_010280.2

3D structure databases

ProteinModelPortaliB0BBS8
SMRiB0BBS8
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAP06943; CAP06943; CTLon_0545
KEGGictl:CTLon_0545

Phylogenomic databases

HOGENOMiHOG000246808
KOiK03685
OMAiLTHKSCK

Family and domain databases

CDDicd00048 DSRM, 1 hit
cd00593 RIBOc, 1 hit
Gene3Di1.10.1520.10, 1 hit
HAMAPiMF_00104 RNase_III, 1 hit
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR011907 RNase_III
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF00035 dsrm, 1 hit
PF14622 Ribonucleas_3_3, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 1 hit
SM00535 RIBOc, 1 hit
SUPFAMiSSF69065 SSF69065, 1 hit
TIGRFAMsiTIGR02191 RNaseIII, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRNC_CHLTB
AccessioniPrimary (citable) accession number: B0BBS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 26, 2008
Last modified: October 10, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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