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UniProtKB - B0AZR9 (B0AZR9_HUMAN)
Protein
Submitted name:
GNAS complex locus, isoform CRA_b
Gene
GNAS
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- G-protein beta/gamma-subunit complex binding Source: InterPro
- GTPase activity Source: InterPro
- GTP binding Source: InterPro
GO - Biological processi
Keywordsi
Molecular function | TransducerARBA annotation |
Ligand | Metal-bindingARBA annotation, Nucleotide-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: GNAS complex locus, isoform CRA_bImportedSubmitted name: Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortImportedSubmitted name: cDNA, FLJ79509, highly similar to Guanine nucleotide-binding protein G(s)subunit alphaImportedSubmitted name: cDNA, FLJ79523, highly similar to Guanine nucleotide-binding protein G(s)subunit alphaImported |
Gene namesi | Name:GNASImported ORF Names:hCG_1788380Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4392, GNAS |
VEuPathDBi | HostDB:ENSG00000087460 |
Expressioni
Gene expression databases
Bgeei | ENSG00000087460, Expressed in type B pancreatic cell and 265 other tissues |
ExpressionAtlasi | S4R3V9, baseline and differential |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 32 | DisorderedSequence analysisAdd BLAST | 32 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 33 – 53 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000156300 |
HOGENOMi | CLU_014184_6_2_1 |
OrthoDBi | 754573at2759 |
Family and domain databases
CDDi | cd00066, G-alpha, 1 hit |
Gene3Di | 1.10.400.10, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR000367, Gprotein_alpha_S IPR001019, Gprotein_alpha_su IPR011025, GproteinA_insert IPR027417, P-loop_NTPase |
PANTHERi | PTHR10218, PTHR10218, 1 hit |
Pfami | View protein in Pfam PF00503, G-alpha, 1 hit |
PRINTSi | PR00318, GPROTEINA PR00443, GPROTEINAS |
SMARTi | View protein in SMART SM00275, G_alpha, 1 hit |
SUPFAMi | SSF47895, SSF47895, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51882, G_ALPHA, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 24 potential isoforms that are computationally mapped.Show allAlign All
B0AZR9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRILHVNGFN GEGGEEDPQA ARSNSDGEKA TKVQDIKNNL KEAIETIVAA
60 70 80 90 100
MSNLVPPVEL ANPENQFRVD YILSVMNVPD FDFPPEFYEH AKALWEDEGV
110 120 130 140 150
RACYERSNEY QLIDCAQYFL DKIDVIKQAD YVPSDQDLLR CRVLTSGIFE
160 170 180 190 200
TKFQVDKVNF HMFDVGGQRD ERRKWIQCFN DVTAIIFVVA SSSYNMVIRE
210 220 230 240 250
DNQTNRLQEA LNLFKSIWNN RWLRTISVIL FLNKQDLLAE KVLAGKSKIE
260 270 280 290 300
DYFPEFARYT TPEDATPEPG EDPRVTRAKY FIRDEFLRIS TASGDGRHYC
310 320 330
YPHFTCAVDT ENIRRVFNDC RDIIQRMHLR QYELL
Computationally mapped potential isoform sequencesi
There are 24 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP63092 | GNAS2_HUMAN | Guanine nucleotide-binding protein ... | GNAS GNAS1, GSP | 394 | Annotation score: | ||
Q5JWF2 | GNAS1_HUMAN | Guanine nucleotide-binding protein ... | GNAS GNAS1 | 1,037 | Annotation score: | ||
P84996 | ALEX_HUMAN | Protein ALEX | GNAS GNAS1 | 626 | Annotation score: | ||
O95467 | GNAS3_HUMAN | Neuroendocrine secretory protein 55 | GNAS GNAS1 | 245 | Annotation score: | ||
Q5JWE9 | Q5JWE9_HUMAN | Guanine nucleotide-binding protein ... | GNAS | 1,022 | Annotation score: | ||
A0A590UJS2 | A0A590UJS2_HUMAN | Guanine nucleotide-binding protein ... | GNAS | 368 | Annotation score: | ||
A0A7I2V5R6 | A0A7I2V5R6_HUMAN | Guanine nucleotide-binding protein ... | GNAS | 1,038 | Annotation score: | ||
A0A0A0MR13 | A0A0A0MR13_HUMAN | Guanine nucleotide-binding protein ... | GNAS | 362 | Annotation score: | ||
A0A590UJQ9 | A0A590UJQ9_HUMAN | Guanine nucleotide-binding protein ... | GNAS | 336 | Annotation score: | ||
A0A590UJF0 | A0A590UJF0_HUMAN | Guanine nucleotide-binding protein ... | GNAS | 320 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL109840 Genomic DNA No translation available. AL121917 Genomic DNA No translation available. AL132655 Genomic DNA No translation available. KF456967 Genomic DNA No translation available. AK315860 mRNA Translation: BAF98751.1 AK315874 mRNA Translation: BAF98765.1 CH471077 Genomic DNA Translation: EAW75458.1 CH471077 Genomic DNA Translation: EAW75471.1 |
RefSeqi | NP_001296769.1, NM_001309840.1 NP_001296790.1, NM_001309861.1 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL109840 Genomic DNA No translation available. AL121917 Genomic DNA No translation available. AL132655 Genomic DNA No translation available. KF456967 Genomic DNA No translation available. AK315860 mRNA Translation: BAF98751.1 AK315874 mRNA Translation: BAF98765.1 CH471077 Genomic DNA Translation: EAW75458.1 CH471077 Genomic DNA Translation: EAW75471.1 |
RefSeqi | NP_001296769.1, NM_001309840.1 NP_001296790.1, NM_001309861.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 4152, 783 antibodies from 44 providers |
DNASUi | 2778 |
Genome annotation databases
Organism-specific databases
CTDi | 2778 |
HGNCi | HGNC:4392, GNAS |
OpenTargetsi | ENSG00000087460 |
VEuPathDBi | HostDB:ENSG00000087460 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156300 |
HOGENOMi | CLU_014184_6_2_1 |
OrthoDBi | 754573at2759 |
Miscellaneous databases
BioGRID-ORCSi | 2778, 22 hits in 1058 CRISPR screens |
ChiTaRSi | GNAS, human |
GenomeRNAii | 2778 |
Gene expression databases
Bgeei | ENSG00000087460, Expressed in type B pancreatic cell and 265 other tissues |
ExpressionAtlasi | S4R3V9, baseline and differential |
Family and domain databases
CDDi | cd00066, G-alpha, 1 hit |
Gene3Di | 1.10.400.10, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR000367, Gprotein_alpha_S IPR001019, Gprotein_alpha_su IPR011025, GproteinA_insert IPR027417, P-loop_NTPase |
PANTHERi | PTHR10218, PTHR10218, 1 hit |
Pfami | View protein in Pfam PF00503, G-alpha, 1 hit |
PRINTSi | PR00318, GPROTEINA PR00443, GPROTEINAS |
SMARTi | View protein in SMART SM00275, G_alpha, 1 hit |
SUPFAMi | SSF47895, SSF47895, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51882, G_ALPHA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B0AZR9_HUMAN | |
Accessioni | B0AZR9Primary (citable) accession number: B0AZR9 Secondary accession number(s): A0A590UJ22 S4R3V9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 26, 2008 |
Last sequence update: | February 26, 2008 | |
Last modified: | January 19, 2022 | |
This is version 104 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |