UniProtKB - B0AZM9 (B0AZM9_HUMAN)
Protein
Non-specific serine/threonine protein kinase
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 479 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- protein serine kinase activity Source: UniProtKB-EC
- protein threonine kinase activity Source: UniProtKB-EC
GO - Biological processi
- apoptotic process Source: InterPro
- cytoskeleton organization Source: InterPro
Keywordsi
Molecular function | KinaseImported, Transferase |
Ligand | ATP-bindingPROSITE-ProRule annotation, Nucleotide-binding |
Enzyme and pathway databases
SignaLinki | B0AZM9 |
Names & Taxonomyi
Protein namesi | Recommended name: Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation) |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm ARBA annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 24 | CRIBInterPro annotationAdd BLAST | 14 | |
Domaini | 449 – 700 | Protein kinaseInterPro annotationAdd BLAST | 252 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 29 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 97 – 123 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 256 – 299 | DisorderedSequence analysisAdd BLAST | 44 | |
Regioni | 340 – 373 | DisorderedSequence analysisAdd BLAST | 34 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 15 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 97 – 111 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 270 – 291 | PolarSequence analysisAdd BLAST | 22 | |
Compositional biasi | 354 – 373 | PolarSequence analysisAdd BLAST | 20 |
Phylogenomic databases
OMAi | HAKPPGY |
Family and domain databases
CDDi | cd01093, CRIB_PAK_like, 1 hit |
Gene3Di | 3.90.810.10, 1 hit |
InterProi | View protein in InterPro IPR000095, CRIB_dom IPR036936, CRIB_dom_sf IPR011009, Kinase-like_dom_sf IPR028754, PAK5 IPR033923, PAK_BD IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS |
PANTHERi | PTHR45832:SF4, PTHR45832:SF4, 1 hit |
Pfami | View protein in Pfam PF00786, PBD, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00285, PBD, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50108, CRIB, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit |
i Sequence
Sequence statusi: Complete.
B0AZM9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFGKKKKKIE ISGPSNFEHR VHTGFDPQEQ KFTGLPQQWH SLLADTANRP
60 70 80 90 100
KPMVDPSCIT PIQLAPMKTI VRGNKPCKET SINGLLEDFD NISVTRSNSL
110 120 130 140 150
RKESPPTPDQ GASSHGPGHA EENGFITFSQ YSSESDTTAD YTTEKYREKS
160 170 180 190 200
LYGDDLDPYY RGSHAAKQNG HVMKMKHGEA YYSEVKPLKS DFARFSADYH
210 220 230 240 250
SHLDSLSKPS EYSDLKWEYQ RASSSSPLDY SFQFTPSRTA GTSGCSKESL
260 270 280 290 300
AYSESEWGPS LDDYDRRPKS SYLNQTSPQP TMRQRSRSGS GLQEPMMPFG
310 320 330 340 350
ASAFKTHPQG HSYNSYTYPR LSEPTMCIPK VDYDRAQMVL SPPLSGSDTY
360 370 380 390 400
PRGPAKLPQS QSKSGYSSSS HQYPSGYHKA TLYHHPSLQS SSQYISTASY
410 420 430 440 450
LSSLSLSSST YPPPSWGSSS DQQPSRVSHE QFRAALQLVV SPGDPREYLA
460 470 480 490 500
NFIKIGEGST GIVCIATEKH TGKQVAVKKM DLRKQQRREL LFNEVVIMRD
510 520 530 540 550
YHHDNVVDMY SSYLVGDELW VVMEFLEGGA LTDIVTHTRM NEEQIATVCL
560 570 580 590 600
SVPRALSYLH NQGVIHRDIK SDSILLTSDG RIKLSDFGFC AQVSKEVPKR
610 620 630 640 650
KSLVGTPYWM APEVISRLPY GTEVDIWSLG IMVIEMIDGE PPYFNEPPLQ
660 670 680 690 700
AMRRIRDSLP PRVKDLHKVS SVLRGFLDLM LVREPSQRAT AQELLGHPFL
710
KLAGPPSCIV PLMRQYRHH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK315820 mRNA Translation: BAF98711.1 |
RefSeqi | NP_065074.1, NM_020341.3 NP_817127.1, NM_177990.2 |
Genome annotation databases
GeneIDi | 57144 |
KEGGi | hsa:57144 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK315820 mRNA Translation: BAF98711.1 |
RefSeqi | NP_065074.1, NM_020341.3 NP_817127.1, NM_177990.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
DNASUi | 57144 |
Genome annotation databases
GeneIDi | 57144 |
KEGGi | hsa:57144 |
Organism-specific databases
CTDi | 57144 |
PharmGKBi | PA32922 |
Phylogenomic databases
OMAi | HAKPPGY |
Enzyme and pathway databases
SignaLinki | B0AZM9 |
Miscellaneous databases
BioGRID-ORCSi | 57144, 6 hits in 1018 CRISPR screens |
GenomeRNAii | 57144 |
Gene expression databases
Genevisiblei | B0AZM9, HS |
Family and domain databases
CDDi | cd01093, CRIB_PAK_like, 1 hit |
Gene3Di | 3.90.810.10, 1 hit |
InterProi | View protein in InterPro IPR000095, CRIB_dom IPR036936, CRIB_dom_sf IPR011009, Kinase-like_dom_sf IPR028754, PAK5 IPR033923, PAK_BD IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS |
PANTHERi | PTHR45832:SF4, PTHR45832:SF4, 1 hit |
Pfami | View protein in Pfam PF00786, PBD, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00285, PBD, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50108, CRIB, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B0AZM9_HUMAN | |
Accessioni | B0AZM9Primary (citable) accession number: B0AZM9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 26, 2008 |
Last sequence update: | February 26, 2008 | |
Last modified: | April 7, 2021 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |