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Entry version 84 (02 Jun 2021)
Sequence version 1 (05 Feb 2008)
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Protein

Fer-1-like protein 4

Gene

FER1L4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1265Calcium 1PROSITE-ProRule annotation1
Metal bindingi1265Calcium 2PROSITE-ProRule annotation1
Metal bindingi1271Calcium 1PROSITE-ProRule annotation1
Metal bindingi1320Calcium 1PROSITE-ProRule annotation1
Metal bindingi1320Calcium 2PROSITE-ProRule annotation1
Metal bindingi1322Calcium 1PROSITE-ProRule annotation1
Metal bindingi1322Calcium 2PROSITE-ProRule annotation1
Metal bindingi1328Calcium 2PROSITE-ProRule annotation1
Metal bindingi1596Calcium 3PROSITE-ProRule annotation1
Metal bindingi1599Calcium 3PROSITE-ProRule annotation1
Metal bindingi1602Calcium 3PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
A9Z1Z3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fer-1-like protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FER1L4
Synonyms:C20orf124
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15801, FER1L4

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A9Z1Z3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 1760CytoplasmicSequence analysisAdd BLAST1760
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1761 – 1781HelicalSequence analysisAdd BLAST21
Topological domaini1782 – 1794ExtracellularSequence analysisAdd BLAST13

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
A9Z1Z3, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HGNC:15801

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003464221 – 1794Fer-1-like protein 4Add BLAST1794

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A9Z1Z3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A9Z1Z3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
A9Z1Z3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A9Z1Z3

PeptideAtlas

More...
PeptideAtlasi
A9Z1Z3

PRoteomics IDEntifications database

More...
PRIDEi
A9Z1Z3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
2526 [A9Z1Z3-1]
2527 [A9Z1Z3-2]
2528 [A9Z1Z3-3]
2529 [A9Z1Z3-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A9Z1Z3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A9Z1Z3

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
A9Z1Z3, 1 interactor

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
A9Z1Z3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 129C2 1PROSITE-ProRule annotationAdd BLAST123
Domaini168 – 301C2 2PROSITE-ProRule annotationAdd BLAST134
Domaini745 – 872C2 3PROSITE-ProRule annotationAdd BLAST128
Domaini920 – 1043C2 4PROSITE-ProRule annotationAdd BLAST124
Domaini1231 – 1350C2 5PROSITE-ProRule annotationAdd BLAST120
Domaini1476 – 1625C2 6PROSITE-ProRule annotationAdd BLAST150

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni353 – 401DisorderedSequence analysisAdd BLAST49
Regioni463 – 507DisorderedSequence analysisAdd BLAST45
Regioni1037 – 1059DisorderedSequence analysisAdd BLAST23
Regioni1662 – 1686DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi486 – 503Basic and acidic residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ferlin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A9Z1Z3

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A9Z1Z3

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04011, C2B_Ferlin, 1 hit
cd04018, C2C_Ferlin, 1 hit
cd04017, C2D_Ferlin, 1 hit
cd04037, C2E_Ferlin, 1 hit
cd08374, C2F_Ferlin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR037720, C2B_Ferlin
IPR037722, C2C_Ferlin
IPR037723, C2D_Ferlin
IPR037724, C2E_Ferlin
IPR037725, C2F_Ferlin
IPR030001, Fer1l4
IPR012968, FerIin_dom
IPR037721, Ferlin
IPR012561, Ferlin_B-domain
IPR032362, Ferlin_C

The PANTHER Classification System

More...
PANTHERi
PTHR12546, PTHR12546, 1 hit
PTHR12546:SF36, PTHR12546:SF36, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168, C2, 5 hits
PF08150, FerB, 1 hit
PF08151, FerI, 1 hit
PF16165, Ferlin_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239, C2, 5 hits
SM01201, FerB, 1 hit
SM01202, FerI, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004, C2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: A9Z1Z3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFSPLKSRAR ALAHGDPFQV SRAQDFQVGV TVLEAQKLVG VNINPYVAVQ
60 70 80 90 100
VGGQRRVTAT QRGTSCPFYN EYFLFEFHDT RLRLQDLLLE ITAFHSQTLP
110 120 130 140 150
FMATRIGTFR MDLGIILDQP DGQFYQRWVP LHDPRDTRAG TKGFIKVTLS
160 170 180 190 200
VRARGDLPPP MLPPAPGHCS DIEKNLLLPR GVPAERPWAR LRVRLYRAEG
210 220 230 240 250
LPALRLGLLG SLVRALHDQR VLVEPYVRVS FLGQEGETSV SAEAAAPEWN
260 270 280 290 300
EQLSFVELFP PLTRSLRLQL RDDAPLVDAA LATHVPDLRR ISHPGRAAGF
310 320 330 340 350
NPTFGPAWVP LYGSPPGAGL RDSLQGLNEG VGQGIWFRGR LLLAVSMQVL
360 370 380 390 400
EGRAEPEPPQ AQQGSTLSRL TRKKKKKARR DQTPKAVPQH LDASPGAEGP
410 420 430 440 450
EIPRAMEVEV EELLPLPENV LAPCEDFLLF GVLFEATMID PTVASQPISF
460 470 480 490 500
EISIGRAGRL EEQLGRGSRA GEGTEGAAVE AQPLLGARPE EEKEEEELGT
510 520 530 540 550
HAQRPEPMDG SGPYFCLPLC HCKPCMHVWS CWEDHTWRLQ SSNCVRKVAE
560 570 580 590 600
RLDQGLQEVE RLQRKPGPGA CAQLKQALEV LVAGSRQFCH GAERRTMTRP
610 620 630 640 650
NALDRCRGKL LVHSLNLLAK QGLRLLRGLR RRNVQKKVAL AKKLLAKLRF
660 670 680 690 700
LAEEPQPPLP DVLVWMLSGQ RRVAWARIPA QDVLFSVVEE ERGRDCGKIQ
710 720 730 740 750
SLMLTAPGAA PGEVCAKLEL FLRLGLGKQA KACTSELPPD LLPEPSAGLP
760 770 780 790 800
SSLHRDDFSY FQLRAHLYQA RGVLAADDSG LSDPFARVLI STQCQTTRVL
810 820 830 840 850
EQTLSPLWDE LLVFEQLIVD GRREHLQEEP PLVIINVFDH NKFGPPVFLG
860 870 880 890 900
RALAAPRVKL MEDPYQRPEL QFFPLRKGPW AAGELIAAFQ LIELDYSGRL
910 920 930 940 950
EPSVPSEVEP QDLAPLVEPH SGRLSLPPNV CPVLREFRVE VLFWGLRGLG
960 970 980 990 1000
RVHLLEVEQP QVVLEVAGQG VESEVLASYR ESPNFTELVR HLTVDLPEQP
1010 1020 1030 1040 1050
YLQPPLSILV IERRAFGHTV LVGSHIVPHM LRFTFRGHED PPEEEGEMEE
1060 1070 1080 1090 1100
TGDMMPKGPQ GQKSLDPFLA EAGISRQLLK PPLKKLPLGG LLNQGPGLEE
1110 1120 1130 1140 1150
DIPDPEELDW GSKYYASLQE LQGQHNFDED EMDDPGDSDG VNLISMVGEI
1160 1170 1180 1190 1200
QDQGEAEVKG TVSPKKAVAT LKIYNRSLKE EFNHFEDWLN VFPLYRGQGG
1210 1220 1230 1240 1250
QDGGGEEEGS GHLVGKFKGS FLIYPESEAV LFSEPQISRG IPQNRPIKLL
1260 1270 1280 1290 1300
VRVYVVKATN LAPADPNGKA DPYVVVSAGR ERQDTKERYI PKQLNPIFGE
1310 1320 1330 1340 1350
ILELSISLPA ETELTVAVFD HDLVGSDDLI GETHIDLENR FYSHHRANCG
1360 1370 1380 1390 1400
LASQYEVDGY NAWRDAFWPS QILAGLCQRC GLPAPEYRAG AVKVGSKVFL
1410 1420 1430 1440 1450
TPPETLPPGS SSPTVASGDP EEAQALLVLR RWQEMPGFGI QLVPEHVETR
1460 1470 1480 1490 1500
PLYHPHSPGL LQGSLHMWID IFPQDVPAPP PVDIKPRQPI SYELRVVIWN
1510 1520 1530 1540 1550
TEDVVLDDEN PLTGEMSSDI YVKSWVKGLE HDKQETDVHF NSLTGEGNFN
1560 1570 1580 1590 1600
WRFVFRFDYL PTEREVSVWR RSGPFALEEA EFRQPAVLVL QVWDYDRISA
1610 1620 1630 1640 1650
NDFLGSLELQ LPDMVRGARG PELCSVQLAR NGAGPRCNLF RCRRLRGWWP
1660 1670 1680 1690 1700
VVKLKEAEDV EREAQEAQAG KKKRKQRRRK GRPEDLEFTD MGGNVYILTG
1710 1720 1730 1740 1750
KVEAEFELLT VEEAEKRPVG KGRKQPEPLE KPSRPKTSFN WFVNPLKTFV
1760 1770 1780 1790
FFIWRRYWRT LVLLLLVLLT VFLLLVFYTI PGQISQVIFR PLHK
Length:1,794
Mass (Da):200,980
Last modified:February 5, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA057803847E74EC2
GO
Isoform 2 (identifier: A9Z1Z3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1466: Missing.

Show »
Length:328
Mass (Da):38,388
Checksum:iB9090FF0D858C06A
GO
Isoform 3 (identifier: A9Z1Z3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1358-1367: DGYNAWRDAF → WVQQGPQEPF
     1368-1794: Missing.

Show »
Length:1,367
Mass (Da):151,987
Checksum:i49144DEFA13010BA
GO
Isoform 4 (identifier: A9Z1Z3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     92-92: T → TVSGVGVTSVLQRRGDEKAAGLTPPSPK
     121-127: DGQFYQR → GMESSPY
     128-1794: Missing.

Show »
Length:154
Mass (Da):17,030
Checksum:i1AA8CBBE0A16C9E2
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14597 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1320D → E in BAB14597 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0458931179K → E. Corresponds to variant dbSNP:rs1557202Ensembl.1
Natural variantiVAR_0458941183N → S. Corresponds to variant dbSNP:rs11698021Ensembl.1
Natural variantiVAR_0458951318V → I. Corresponds to variant dbSNP:rs2277862Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0349841 – 1466Missing in isoform 2. 1 PublicationAdd BLAST1466
Alternative sequenceiVSP_03498592T → TVSGVGVTSVLQRRGDEKAA GLTPPSPK in isoform 4. 1 Publication1
Alternative sequenceiVSP_034986121 – 127DGQFYQR → GMESSPY in isoform 4. 1 Publication7
Alternative sequenceiVSP_034987128 – 1794Missing in isoform 4. 1 PublicationAdd BLAST1667
Alternative sequenceiVSP_0349881358 – 1367DGYNAWRDAF → WVQQGPQEPF in isoform 3. 1 Publication10
Alternative sequenceiVSP_0349891368 – 1794Missing in isoform 3. 1 PublicationAdd BLAST427

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK023521 mRNA Translation: BAB14597.1 Different initiation.
AK026266 mRNA Translation: BAB15420.1
AF218012 mRNA Translation: AAG17254.1
AF218030 mRNA Translation: AAG17272.1
AL121586, AL109827, AL389875 Genomic DNA Translation: CAB89410.2
AL109827, AL121586, AL389875 Genomic DNA Translation: CAI20117.2
BC029951 mRNA No translation available.

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023521 mRNA Translation: BAB14597.1 Different initiation.
AK026266 mRNA Translation: BAB15420.1
AF218012 mRNA Translation: AAG17254.1
AF218030 mRNA Translation: AAG17272.1
AL121586, AL109827, AL389875 Genomic DNA Translation: CAB89410.2
AL109827, AL121586, AL389875 Genomic DNA Translation: CAI20117.2
BC029951 mRNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
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Protein-protein interaction databases

IntActiA9Z1Z3, 1 interactor

PTM databases

iPTMnetiA9Z1Z3
PhosphoSitePlusiA9Z1Z3

Genetic variation databases

BioMutaiHGNC:15801

Proteomic databases

EPDiA9Z1Z3
jPOSTiA9Z1Z3
MassIVEiA9Z1Z3
MaxQBiA9Z1Z3
PeptideAtlasiA9Z1Z3
PRIDEiA9Z1Z3
ProteomicsDBi2526 [A9Z1Z3-1]
2527 [A9Z1Z3-2]
2528 [A9Z1Z3-3]
2529 [A9Z1Z3-4]

Organism-specific databases

GeneCards: human genes, protein and diseases

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GeneCardsi
FER1L4
HGNCiHGNC:15801, FER1L4
neXtProtiNX_A9Z1Z3

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

InParanoidiA9Z1Z3
PhylomeDBiA9Z1Z3

Enzyme and pathway databases

PathwayCommonsiA9Z1Z3

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FER1L4, human
PharosiA9Z1Z3, Tdark

Protein Ontology

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PROi
PR:A9Z1Z3
RNActiA9Z1Z3, protein

Family and domain databases

CDDicd04011, C2B_Ferlin, 1 hit
cd04018, C2C_Ferlin, 1 hit
cd04017, C2D_Ferlin, 1 hit
cd04037, C2E_Ferlin, 1 hit
cd08374, C2F_Ferlin, 1 hit
Gene3Di2.60.40.150, 5 hits
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR037720, C2B_Ferlin
IPR037722, C2C_Ferlin
IPR037723, C2D_Ferlin
IPR037724, C2E_Ferlin
IPR037725, C2F_Ferlin
IPR030001, Fer1l4
IPR012968, FerIin_dom
IPR037721, Ferlin
IPR012561, Ferlin_B-domain
IPR032362, Ferlin_C
PANTHERiPTHR12546, PTHR12546, 1 hit
PTHR12546:SF36, PTHR12546:SF36, 1 hit
PfamiView protein in Pfam
PF00168, C2, 5 hits
PF08150, FerB, 1 hit
PF08151, FerI, 1 hit
PF16165, Ferlin_C, 1 hit
SMARTiView protein in SMART
SM00239, C2, 5 hits
SM01201, FerB, 1 hit
SM01202, FerI, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 6 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFR1L4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A9Z1Z3
Secondary accession number(s): Q9GZQ9, Q9H646, Q9H8L7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: February 5, 2008
Last modified: June 2, 2021
This is version 84 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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