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Protein
Submitted name:

Dopamine receptor 2 protein transcript variant 1

Gene

DRD2

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • adrenergic receptor activity Source: GO_Central
  • dopamine binding Source: Ensembl
  • dopamine neurotransmitter receptor activity, coupled via Gi/Go Source: Ensembl
  • identical protein binding Source: Ensembl
  • organic cyclic compound binding Source: AgBase

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptorUniRule annotation, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-GGA-390651 Dopamine receptors
R-GGA-418594 G alpha (i) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Dopamine receptor 2 protein transcript variant 1Imported
Submitted name:
Dopamine receptor D2Imported
Submitted name:
Dopamine receptor D2 long isoformImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DRD2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 24

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei33 – 56HelicalSequence analysisAdd BLAST24
Transmembranei68 – 90HelicalSequence analysisAdd BLAST23
Transmembranei106 – 128HelicalSequence analysisAdd BLAST23
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Transmembranei189 – 213HelicalSequence analysisAdd BLAST25
Transmembranei368 – 389HelicalSequence analysisAdd BLAST22
Transmembranei401 – 423HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSGALG00000007794 Expressed in 1 organ(s), highest expression level in brain

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000012625

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini48 – 420G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST373

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3656 Eukaryota
ENOG410XRW9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155539

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000239242

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG106962

KEGG Orthology (KO)

More...
KOi
K04145

Identification of Orthologs from Complete Genome Data

More...
OMAi
MITRSFG

Database of Orthologous Groups

More...
OrthoDBi
EOG091G06VI

TreeFam database of animal gene trees

More...
TreeFami
TF334382

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001922 Dopamine_D2_rcpt
IPR000929 Dopamine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00567 DOPAMINED2R
PR00242 DOPAMINER
PR00237 GPCRRHODOPSN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A9YZQ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPLNLSWYN SGDRNWSKPL NESSADQKPQ YNYYAVLLTL LIFVIVFGNV
60 70 80 90 100
LVCMAVSREK ALQTTTNYLI VSLAVADLLV ATLVMPWVVY LEVVGEWRFS
110 120 130 140 150
RIHCDIFVTL DVMMCTASIL NLCAISIDRY TAVAMPMLYN TRYSSKRRVT
160 170 180 190 200
VMIAVVWVLS FAISSPILFG LNKADEKECI IANPAFVVYS SVVSFYVPFI
210 220 230 240 250
VTLLVYVQIY IVLRKRRKRV TTKRSSHVLD SDTQAPLKDK CTHPEDVKLC
260 270 280 290 300
TVIVKSNGSF QVNKRKVEAE SHIEMEMEMV SSTSPPERTL AKPAAPSNHQ
310 320 330 340 350
LVVPIASRRC TLDSPGKVEK NGHAKENLHT AKVFEIQSMP NGKTRSTLLK
360 370 380 390 400
AMNRRKLSQQ KEKKATQMLA IVLGVFIICW LPFFITHILN MHCDCNIPPA
410 420 430
MYSAFTWLGY VNSAVNPIIY TTFNIEFRKA FMKILHC
Length:437
Mass (Da):49,543
Last modified:February 5, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i445259E9E2162DB7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5PDB7A0A1D5PDB7_CHICK
Uncharacterized protein
DRD2
399Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5PQP0A0A1D5PQP0_CHICK
Uncharacterized protein
DRD2
375Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AADN04000117 Genomic DNA No translation available.
EU313425 mRNA Translation: ABY28377.1
MF967037 mRNA Translation: AUL82233.1
AB688630 Genomic DNA Translation: BAP27873.1
AB688631 Genomic DNA Translation: BAP27874.1
AB688632 Genomic DNA Translation: BAP27875.1
AB688633 Genomic DNA Translation: BAP27876.1
AB688634 Genomic DNA Translation: BAP27877.1
AB688636 Genomic DNA Translation: BAP27878.1
AB688637 Genomic DNA Translation: BAP27879.1
AB688638 Genomic DNA Translation: BAP27880.1
AB688639 Genomic DNA Translation: BAP27881.1
AB688642 Genomic DNA Translation: BAP27882.1
AB688643 Genomic DNA Translation: BAP27883.1
AB688646 Genomic DNA Translation: BAP27886.1
AB688647 Genomic DNA Translation: BAP27887.1
AB688649 Genomic DNA Translation: BAP27889.1
AB688650 Genomic DNA Translation: BAP27890.1
AB688651 Genomic DNA Translation: BAP27891.1
AB688652 Genomic DNA Translation: BAP27892.1
AB688653 Genomic DNA Translation: BAP27893.1
AB688654 Genomic DNA Translation: BAP27894.1
AB688656 Genomic DNA Translation: BAP27896.1
AB688657 Genomic DNA Translation: BAP27897.1
AB688658 Genomic DNA Translation: BAP27898.1

NCBI Reference Sequences

More...
RefSeqi
NP_001106761.1, NM_001113290.1
XP_015153515.1, XM_015298029.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Gga.47299

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGALT00000012639; ENSGALP00000012625; ENSGALG00000007794

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
428252

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:428252

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000117 Genomic DNA No translation available.
EU313425 mRNA Translation: ABY28377.1
MF967037 mRNA Translation: AUL82233.1
AB688630 Genomic DNA Translation: BAP27873.1
AB688631 Genomic DNA Translation: BAP27874.1
AB688632 Genomic DNA Translation: BAP27875.1
AB688633 Genomic DNA Translation: BAP27876.1
AB688634 Genomic DNA Translation: BAP27877.1
AB688636 Genomic DNA Translation: BAP27878.1
AB688637 Genomic DNA Translation: BAP27879.1
AB688638 Genomic DNA Translation: BAP27880.1
AB688639 Genomic DNA Translation: BAP27881.1
AB688642 Genomic DNA Translation: BAP27882.1
AB688643 Genomic DNA Translation: BAP27883.1
AB688646 Genomic DNA Translation: BAP27886.1
AB688647 Genomic DNA Translation: BAP27887.1
AB688649 Genomic DNA Translation: BAP27889.1
AB688650 Genomic DNA Translation: BAP27890.1
AB688651 Genomic DNA Translation: BAP27891.1
AB688652 Genomic DNA Translation: BAP27892.1
AB688653 Genomic DNA Translation: BAP27893.1
AB688654 Genomic DNA Translation: BAP27894.1
AB688656 Genomic DNA Translation: BAP27896.1
AB688657 Genomic DNA Translation: BAP27897.1
AB688658 Genomic DNA Translation: BAP27898.1
RefSeqiNP_001106761.1, NM_001113290.1
XP_015153515.1, XM_015298029.1
UniGeneiGga.47299

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000012625

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000012639; ENSGALP00000012625; ENSGALG00000007794
GeneIDi428252
KEGGigga:428252

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1813

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00940000155539
HOGENOMiHOG000239242
HOVERGENiHBG106962
KOiK04145
OMAiMITRSFG
OrthoDBiEOG091G06VI
TreeFamiTF334382

Enzyme and pathway databases

ReactomeiR-GGA-390651 Dopamine receptors
R-GGA-418594 G alpha (i) signalling events

Gene expression databases

BgeeiENSGALG00000007794 Expressed in 1 organ(s), highest expression level in brain

Family and domain databases

InterProiView protein in InterPro
IPR001922 Dopamine_D2_rcpt
IPR000929 Dopamine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00567 DOPAMINED2R
PR00242 DOPAMINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA9YZQ5_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A9YZQ5
Secondary accession number(s): F1NP41
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: December 5, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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