UniProtKB - A9YTQ3 (AHRR_HUMAN)
Aryl hydrocarbon receptor repressor
AHRR
Functioni
Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.
2 PublicationsGO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- nuclear receptor activity Source: GO_Central
- protein dimerization activity Source: InterPro
- transcription cis-regulatory region binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
- xenobiotic metabolic process Source: InterPro
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | A9YTQ3 |
Reactomei | R-HSA-1989781, PPARA activates gene expression R-HSA-211945, Phase I - Functionalization of compounds R-HSA-211976, Endogenous sterols R-HSA-211981, Xenobiotics R-HSA-8937144, Aryl hydrocarbon receptor signalling |
SignaLinki | A9YTQ3 |
Names & Taxonomyi
Protein namesi | Recommended name: Aryl hydrocarbon receptor repressorShort name: AhR repressor Short name: AhRR Alternative name(s): Class E basic helix-loop-helix protein 77 Short name: bHLHe77 |
Gene namesi | Name:AHRR Synonyms:BHLHE77, KIAA1234 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:346, AHRR |
MIMi | 606517, gene |
neXtProti | NX_A9YTQ3 |
VEuPathDBi | HostDB:ENSG00000063438 HostDB:ENSG00000288622 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- aryl hydrocarbon receptor complex Source: GO_Central
- chromatin Source: NTNU_SB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 57491 |
PharmGKBi | PA24639 |
Miscellaneous databases
Pharosi | A9YTQ3, Tbio |
Genetic variation databases
BioMutai | AHRR |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000333857 | 1 – 701 | Aryl hydrocarbon receptor repressorAdd BLAST | 701 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 577 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 660 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
MassIVEi | A9YTQ3 |
PaxDbi | A9YTQ3 |
PeptideAtlasi | A9YTQ3 |
PRIDEi | A9YTQ3 |
ProteomicsDBi | 2518 [A9YTQ3-1] 2519 [A9YTQ3-2] 2520 [A9YTQ3-3] |
PTM databases
iPTMneti | A9YTQ3 |
PhosphoSitePlusi | A9YTQ3 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000063438, Expressed in testis and 149 other tissues |
ExpressionAtlasi | A9YTQ3, differential |
Genevisiblei | A9YTQ3, HS |
Organism-specific databases
HPAi | ENSG00000063438, Tissue enriched (testis) |
Interactioni
Subunit structurei
Interacts with ANKRA2, HDAC4 and HDAC5.
Interacts with ARNT; forms a heterodimer with ARNT (PubMed:28904176).
By similarity1 PublicationGO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 121558, 7 interactors |
STRINGi | 9606.ENSP00000323816 |
Miscellaneous databases
RNActi | A9YTQ3, protein |
Structurei
Secondary structure
3D structure databases
SMRi | A9YTQ3 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 81 | bHLHPROSITE-ProRule annotationAdd BLAST | 54 | |
Domaini | 112 – 182 | PASPROSITE-ProRule annotationAdd BLAST | 71 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 40 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 366 – 434 | DisorderedSequence analysisAdd BLAST | 69 | |
Regioni | 448 – 483 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 551 – 701 | Needed for transcriptional repressionBy similarityAdd BLAST | 151 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 371 – 385 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Phylogenomic databases
eggNOGi | KOG3560, Eukaryota |
HOGENOMi | CLU_023661_0_0_1 |
InParanoidi | A9YTQ3 |
OrthoDBi | 325707at2759 |
PhylomeDBi | A9YTQ3 |
TreeFami | TF352074 |
Family and domain databases
CDDi | cd00130, PAS, 1 hit |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR039091, AHR/AHRR IPR039092, AHRR IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold |
PANTHERi | PTHR10649, PTHR10649, 1 hit PTHR10649:SF3, PTHR10649:SF3, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF00989, PAS, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00091, PAS, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPRTMIPPGE CTYAGRKRRR PLQKQRPAVG AEKSNPSKRH RDRLNAELDH
60 70 80 90 100
LASLLPFPPD IISKLDKLSV LRLSVSYLRV KSFFQVVQEQ SSRQPAAGAP
110 120 130 140 150
SPGDSCPLAG SAVLEGRLLL ESLNGFALVV SAEGTIFYAS ATIVDYLGFH
160 170 180 190 200
QTDVMHQNIY DYIHVDDRQD FCRQLHWAMD PPQVVFGQPP PLETGDDAIL
210 220 230 240 250
GRLLRAQEWG TGTPTEYSAF LTRCFICRVR CLLDSTSGFL TMQFQGKLKF
260 270 280 290 300
LFGQKKKAPS GAMLPPRLSL FCIAAPVLLP SAAEMKMRSA LLRAKPRADT
310 320 330 340 350
AATADAKVKA TTSLCESELH GKPNYSAGRS SRESGVLVLR EQTDAGRWAQ
360 370 380 390 400
VPARAPCLCL RGGPDLVLDP KGGSGDREEE QHRMLSRASG VTGRRETPGP
410 420 430 440 450
TKPLPWTAGK HSEDGARPRL QPSKNDPPSL RPMPRGSCLP CPCVQGTFRN
460 470 480 490 500
SPISHPPSPS PSAYSSRTSR PMRDVGEDQV HPPLCHFPQR SLQHQLPQPG
510 520 530 540 550
AQRFATRGYP MEDMKLQGVP MPPGDLCGPT LLLDVSIKME KDSGCEGAAD
560 570 580 590 600
GCVPSQVWLG ASDRSHPATF PTRMHLKTEP DSRQQVYISH LGHGVRGAQP
610 620 630 640 650
HGRATAGRSR ELTPFHPAHC ACLEPTDGLP QSEPPHQLCA RGRGEQSCTC
660 670 680 690 700
RAAEAAPVVK REPLDSPQWA THSQGMVPGM LPKSALATLV PPQASGCTFL
P
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RE68 | D6RE68_HUMAN | Aryl hydrocarbon receptor repressor | AHRR | 557 | Annotation score: | ||
A0A7I2PK40 | A0A7I2PK40_HUMAN | Aryl hydrocarbon receptor repressor | AHRR | 697 | Annotation score: | ||
E5RFG4 | E5RFG4_HUMAN | Aryl hydrocarbon receptor repressor | AHRR | 157 | Annotation score: | ||
H0YA43 | H0YA43_HUMAN | Aryl hydrocarbon receptor repressor | AHRR | 215 | Annotation score: | ||
G3V143 | G3V143_HUMAN | Aryl hydrocarbon receptor repressor | AHRR hCG_1985585 | 139 | Annotation score: | ||
E5RGQ2 | E5RGQ2_HUMAN | Aryl hydrocarbon receptor repressor | AHRR | 81 | Annotation score: | ||
A0A494BZY4 | A0A494BZY4_HUMAN | Aryl hydrocarbon receptor repressor | AHRR | 92 | Annotation score: | ||
E5RHE0 | E5RHE0_HUMAN | Aryl hydrocarbon receptor repressor | AHRR | 12 | Annotation score: |
Sequence cautioni
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_043308 | 114 | L → P1 PublicationCorresponds to variant dbSNP:rs35008248Ensembl. | 1 | |
Natural variantiVAR_043309 | 189 | P → A4 PublicationsCorresponds to variant dbSNP:rs2292596Ensembl. | 1 | |
Natural variantiVAR_043310 | 373 | G → V. Corresponds to variant dbSNP:rs2303738Ensembl. | 1 | |
Natural variantiVAR_043311 | 627 | D → H. Corresponds to variant dbSNP:rs34453673Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_033563 | 1 – 4 | Missing in isoform 3. Curated | 4 | |
Alternative sequenceiVSP_033564 | 240 | L → LARGSQAWQLRLCCPEPLM in isoform 2 and isoform 3. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF293639 , AF293629, AF293630, AF293631, AF293632, AF293633, AF293634, AF293635, AF293636, AF293637, AF293638 Genomic DNA Translation: AAG33381.1 EU293605 mRNA Translation: ABX89616.1 Different initiation. AB033060 mRNA Translation: BAA86548.1 Different initiation. AC010442 Genomic DNA No translation available. AC118458 Genomic DNA No translation available. CH471235 Genomic DNA Translation: EAW50992.1 BC151852 mRNA Translation: AAI51853.1 BC152406 mRNA Translation: AAI52407.1 |
RefSeqi | NP_001229341.1, NM_001242412.1 NP_065782.2, NM_020731.4 |
Genome annotation databases
GeneIDi | 57491 |
UCSCi | uc003jav.4, human [A9YTQ3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF293639 , AF293629, AF293630, AF293631, AF293632, AF293633, AF293634, AF293635, AF293636, AF293637, AF293638 Genomic DNA Translation: AAG33381.1 EU293605 mRNA Translation: ABX89616.1 Different initiation. AB033060 mRNA Translation: BAA86548.1 Different initiation. AC010442 Genomic DNA No translation available. AC118458 Genomic DNA No translation available. CH471235 Genomic DNA Translation: EAW50992.1 BC151852 mRNA Translation: AAI51853.1 BC152406 mRNA Translation: AAI52407.1 |
RefSeqi | NP_001229341.1, NM_001242412.1 NP_065782.2, NM_020731.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5Y7Y | X-ray | 2.40 | A | 27-280 | [»] | |
SMRi | A9YTQ3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 121558, 7 interactors |
STRINGi | 9606.ENSP00000323816 |
PTM databases
iPTMneti | A9YTQ3 |
PhosphoSitePlusi | A9YTQ3 |
Genetic variation databases
BioMutai | AHRR |
Proteomic databases
MassIVEi | A9YTQ3 |
PaxDbi | A9YTQ3 |
PeptideAtlasi | A9YTQ3 |
PRIDEi | A9YTQ3 |
ProteomicsDBi | 2518 [A9YTQ3-1] 2519 [A9YTQ3-2] 2520 [A9YTQ3-3] |
Protocols and materials databases
Antibodypediai | 78223, 46 antibodies from 7 providers |
DNASUi | 57491 |
Genome annotation databases
GeneIDi | 57491 |
UCSCi | uc003jav.4, human [A9YTQ3-1] |
Organism-specific databases
CTDi | 57491 |
DisGeNETi | 57491 |
GeneCardsi | AHRR |
HGNCi | HGNC:346, AHRR |
HPAi | ENSG00000063438, Tissue enriched (testis) |
MIMi | 606517, gene |
neXtProti | NX_A9YTQ3 |
PharmGKBi | PA24639 |
VEuPathDBi | HostDB:ENSG00000063438 HostDB:ENSG00000288622 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3560, Eukaryota |
HOGENOMi | CLU_023661_0_0_1 |
InParanoidi | A9YTQ3 |
OrthoDBi | 325707at2759 |
PhylomeDBi | A9YTQ3 |
TreeFami | TF352074 |
Enzyme and pathway databases
PathwayCommonsi | A9YTQ3 |
Reactomei | R-HSA-1989781, PPARA activates gene expression R-HSA-211945, Phase I - Functionalization of compounds R-HSA-211976, Endogenous sterols R-HSA-211981, Xenobiotics R-HSA-8937144, Aryl hydrocarbon receptor signalling |
SignaLinki | A9YTQ3 |
Miscellaneous databases
BioGRID-ORCSi | 57491, 8 hits in 1059 CRISPR screens |
ChiTaRSi | AHRR, human |
GenomeRNAii | 57491 |
Pharosi | A9YTQ3, Tbio |
PROi | PR:A9YTQ3 |
RNActi | A9YTQ3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000063438, Expressed in testis and 149 other tissues |
ExpressionAtlasi | A9YTQ3, differential |
Genevisiblei | A9YTQ3, HS |
Family and domain databases
CDDi | cd00130, PAS, 1 hit |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR039091, AHR/AHRR IPR039092, AHRR IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold |
PANTHERi | PTHR10649, PTHR10649, 1 hit PTHR10649:SF3, PTHR10649:SF3, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF00989, PAS, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00091, PAS, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AHRR_HUMAN | |
Accessioni | A9YTQ3Primary (citable) accession number: A9YTQ3 Secondary accession number(s): A7MBN5 Q9ULI6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 20, 2008 |
Last sequence update: | November 2, 2010 | |
Last modified: | February 23, 2022 | |
This is version 122 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references