UniProtKB - A9XTE5 (A9XTE5_HUMAN)
Protein
Caveolin
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.UniRule annotation
GO - Biological processi
- caveola assembly Source: InterPro
Names & Taxonomyi
Protein namesi | Recommended name: CaveolinUniRule annotation |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane UniRule annotation; Peripheral membrane protein UniRule annotation
Plasma membrane
- Cell membrane UniRule annotationARBA annotation; Peripheral membrane protein UniRule annotationARBA annotation
Other locations
- caveola UniRule annotationARBA annotation; Peripheral membrane protein UniRule annotationARBA annotation
- Membrane raft ARBA annotation
- Membrane ARBA annotation; Peripheral membrane protein ARBA annotation
Golgi apparatus
- Golgi membrane Source: UniProtKB-SubCell
Plasma Membrane
- caveola Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 103 – 127 | HelicalSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
Cell membraneUniRule annotation, Golgi apparatusUniRule annotationARBA annotation, MembranePTM / Processingi
Keywords - PTMi
Lipoprotein, PalmitateARBA annotationProteomic databases
PeptideAtlasi | A9XTE5 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisFamily and domain databases
InterProi | View protein in InterPro IPR015504, CAV-1 IPR001612, Caveolin IPR018361, Caveolin_CS |
PANTHERi | PTHR10844, PTHR10844, 1 hit PTHR10844:SF18, PTHR10844:SF18, 1 hit |
Pfami | View protein in Pfam PF01146, Caveolin, 1 hit |
PROSITEi | View protein in PROSITE PS01210, CAVEOLIN, 1 hit |
i Sequence
Sequence statusi: Fragment.
A9XTE5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
HGAVAVGAGH LYTVPIREQG NIYKPNNKAM ADELSEKQVY DAHTKEIDLV
60 70 80 90 100
NRDPKHLNDD VVKIDFEDVI AEPEGTHSFD GIWKASFTTF TVTKYWFYRL
110 120 130 140 150
LSALFGIPMA LIWGIYFAIL SFLHIWAVVP CIKSFLIEIQ CTSRVYSIYV
160 170
HTVCDPLFEA VGKIFSNVRI NLQKEI
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF649773 mRNA Translation: ABW22625.1 |
RefSeqi | NP_001166368.1, NM_001172897.1 |
Genome annotation databases
GeneIDi | 857 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF649773 mRNA Translation: ABW22625.1 |
RefSeqi | NP_001166368.1, NM_001172897.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | A9XTE5 |
Protocols and materials databases
DNASUi | 857 |
Genome annotation databases
GeneIDi | 857 |
Organism-specific databases
CTDi | 857 |
PharmGKBi | PA26107 |
Miscellaneous databases
BioGRID-ORCSi | 857, 7 hits in 994 CRISPR screens |
GenomeRNAii | 857 |
Gene expression databases
Genevisiblei | A9XTE5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR015504, CAV-1 IPR001612, Caveolin IPR018361, Caveolin_CS |
PANTHERi | PTHR10844, PTHR10844, 1 hit PTHR10844:SF18, PTHR10844:SF18, 1 hit |
Pfami | View protein in Pfam PF01146, Caveolin, 1 hit |
PROSITEi | View protein in PROSITE PS01210, CAVEOLIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A9XTE5_HUMAN | |
Accessioni | A9XTE5Primary (citable) accession number: A9XTE5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 5, 2008 |
Last sequence update: | February 5, 2008 | |
Last modified: | April 7, 2021 | |
This is version 72 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |