UniProtKB - A9XE60 (KBX11_MESEU)
Protein
Potassium channel toxin MeuTXK-beta-1
Gene
N/A
Organism
Mesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus)
Status
Functioni
Has a low affinity binding to potassium channels of rat brain synaptosomes. Displays weak antibacterial activity against Stenotrophomonas sp. Strongly inhibits the development of the Plasmodium berghei ookinetes. Displays slight hemolytic effect on mouse erythrocytes. Induces cytolysis on Xenopus oocytes at high concentrations. Is not toxic on mice and on the insect Tenebrio molitor.1 Publication
GO - Molecular functioni
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- defense response to bacterium Source: UniProtKB-KW
- hemolysis in other organism Source: UniProtKB-KW
Keywordsi
Molecular function | Antibiotic, Antimicrobial, Ion channel impairing toxin, Potassium channel impairing toxin, Toxin |
Biological process | Cytolysis, Hemolysis |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium channel toxin MeuTXK-beta-1Short name: MeuTXKbeta1 |
Organismi | Mesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus) |
Taxonomic identifieri | 34648 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Mesobuthus |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | 1 PublicationAdd BLAST | 19 | |
ChainiPRO_0000394022 | 20 – 91 | Potassium channel toxin MeuTXK-beta-1Add BLAST | 72 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 57 ↔ 78 | PROSITE-ProRule annotation | ||
Disulfide bondi | 64 ↔ 83 | PROSITE-ProRule annotation | ||
Disulfide bondi | 68 ↔ 85 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 54 – 91 | BetaSPN-type CS-alpha/betaPROSITE-ProRule annotationAdd BLAST | 38 |
Sequence similaritiesi
Keywords - Domaini
SignalFamily and domain databases
InterProi | View protein in InterPro IPR029237 Long_scorpion_toxin |
Pfami | View protein in Pfam PF14866 Toxin_38, 1 hit |
PROSITEi | View protein in PROSITE PS51862 BSPN_CSAB, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
A9XE60-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQRNLVVLLF LGMVALSSCG FREKHFQRFV KYAVPESTLR TVLQTVVHKV
60 70 80 90
GKTQFGCPAY QGYCDDHCQD IEKKEGFCHG FKCKCGIPMG F
Mass spectrometryi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF190325 mRNA Translation: ABP35519.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF190325 mRNA Translation: ABP35519.1 |
3D structure databases
SMRi | A9XE60 |
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR029237 Long_scorpion_toxin |
Pfami | View protein in Pfam PF14866 Toxin_38, 1 hit |
PROSITEi | View protein in PROSITE PS51862 BSPN_CSAB, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | KBX11_MESEU | |
Accessioni | A9XE60Primary (citable) accession number: A9XE60 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 18, 2010 |
Last sequence update: | February 5, 2008 | |
Last modified: | June 20, 2018 | |
This is version 25 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- Scorpion potassium channel toxins
Nomenclature of scorpion potassium channel toxins and list of entries - SIMILARITY comments
Index of protein domains and families