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Protein

Aspartate carbamoyltransferase

Gene

pyrB

Organism
Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes (S)-dihydroorotate from bicarbonate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Carbamoyl-phosphate synthase large chain (carB), Carbamoyl-phosphate synthase small chain (carA)
  2. Aspartate carbamoyltransferase (pyrB)
  3. Dihydroorotase (pyrC), Dihydroorotase (pyrC)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-dihydroorotate from bicarbonate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

GO - Molecular functioni

  • amino acid binding Source: InterPro
  • aspartate carbamoyltransferase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

BioCyciCAUR324602:G1GAO-1918-MONOMER
UniPathwayi
UPA00070;UER00116

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate carbamoyltransferaseUniRule annotation (EC:2.1.3.2UniRule annotation)
Alternative name(s):
Aspartate transcarbamylaseUniRule annotation
Short name:
ATCaseUniRule annotation
Gene namesi
Name:pyrBUniRule annotation
Ordered Locus Names:Caur_1891
OrganismiChloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Taxonomic identifieri324602 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesChloroflexineaeChloroflexaceaeChloroflexus
Proteomesi
  • UP000002008 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003291041 – 308Aspartate carbamoyltransferaseAdd BLAST308

Interactioni

Protein-protein interaction databases

STRINGi324602.Caur_1891

Structurei

3D structure databases

ProteinModelPortaliA9WDU7
SMRiA9WDU7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CXT Bacteria
COG0540 LUCA
HOGENOMiHOG000022685
InParanoidiA9WDU7
KOiK00609
OMAiWCDVANM
OrthoDBiPOG091H00PQ

Family and domain databases

Gene3Di3.40.50.1370, 2 hits
HAMAPiMF_00001 Asp_carb_tr, 1 hit
InterProiView protein in InterPro
IPR006132 Asp/Orn_carbamoyltranf_P-bd
IPR006130 Asp/Orn_carbamoylTrfase
IPR036901 Asp/Orn_carbamoylTrfase_sf
IPR002082 Asp_carbamoyltransf
IPR006131 Asp_carbamoyltransf_Asp/Orn-bd
PANTHERiPTHR11405:SF16 PTHR11405:SF16, 1 hit
PfamiView protein in Pfam
PF00185 OTCace, 1 hit
PF02729 OTCace_N, 1 hit
PRINTSiPR00100 AOTCASE
PR00101 ATCASE
SUPFAMiSSF53671 SSF53671, 1 hit
TIGRFAMsiTIGR00670 asp_carb_tr, 1 hit
PROSITEiView protein in PROSITE
PS00097 CARBAMOYLTRANSFERASE, 1 hit

Sequencei

Sequence statusi: Complete.

A9WDU7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTELRRHAID LDNFSATEIE EILETAESMR EVLSREIKQV PALRGKTVVN
60 70 80 90 100
MFFEESTRTR ISFELAARAL SANVVAFTAR GSSVEKGESL VDTVRTLQAL
110 120 130 140 150
GADIIVMRHS QSGAPYLVAR HFRGSLINAG DGRHAHPTQA LLDLYTMQSR
160 170 180 190 200
LGQIRDLHVV IVGDILHSRV VRSNLWGLTR LGARVTLCGP PTLIGPAAFW
210 220 230 240 250
TATWPQVRIA YELDPLLPEA DVVMALRLQK ERMQSGLLPA LREYTRIYGL
260 270 280 290 300
TSERLARLPS HAIVMHPGPM NEGIEIFPEV ATASPAVIEE QVTNGVAVRM

ALLYRMAG
Length:308
Mass (Da):34,064
Last modified:February 5, 2008 - v1
Checksum:i264B726D716B83D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000909 Genomic DNA Translation: ABY35106.1
RefSeqiWP_012257760.1, NC_010175.1
YP_001635495.1, NC_010175.1

Genome annotation databases

EnsemblBacteriaiABY35106; ABY35106; Caur_1891
GeneIDi5826342
KEGGicau:Caur_1891
PATRICifig|324602.8.peg.2160

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000909 Genomic DNA Translation: ABY35106.1
RefSeqiWP_012257760.1, NC_010175.1
YP_001635495.1, NC_010175.1

3D structure databases

ProteinModelPortaliA9WDU7
SMRiA9WDU7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi324602.Caur_1891

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABY35106; ABY35106; Caur_1891
GeneIDi5826342
KEGGicau:Caur_1891
PATRICifig|324602.8.peg.2160

Phylogenomic databases

eggNOGiENOG4105CXT Bacteria
COG0540 LUCA
HOGENOMiHOG000022685
InParanoidiA9WDU7
KOiK00609
OMAiWCDVANM
OrthoDBiPOG091H00PQ

Enzyme and pathway databases

UniPathwayi
UPA00070;UER00116

BioCyciCAUR324602:G1GAO-1918-MONOMER

Family and domain databases

Gene3Di3.40.50.1370, 2 hits
HAMAPiMF_00001 Asp_carb_tr, 1 hit
InterProiView protein in InterPro
IPR006132 Asp/Orn_carbamoyltranf_P-bd
IPR006130 Asp/Orn_carbamoylTrfase
IPR036901 Asp/Orn_carbamoylTrfase_sf
IPR002082 Asp_carbamoyltransf
IPR006131 Asp_carbamoyltransf_Asp/Orn-bd
PANTHERiPTHR11405:SF16 PTHR11405:SF16, 1 hit
PfamiView protein in Pfam
PF00185 OTCace, 1 hit
PF02729 OTCace_N, 1 hit
PRINTSiPR00100 AOTCASE
PR00101 ATCASE
SUPFAMiSSF53671 SSF53671, 1 hit
TIGRFAMsiTIGR00670 asp_carb_tr, 1 hit
PROSITEiView protein in PROSITE
PS00097 CARBAMOYLTRANSFERASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPYRB_CHLAA
AccessioniPrimary (citable) accession number: A9WDU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: February 5, 2008
Last modified: November 7, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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