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Protein

Argininosuccinate synthase

Gene

argG

Organism
Methylobacterium extorquens (strain PA1) (Methylorubrum extorquens)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotationSAAS annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei43ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei96CitrullineUniRule annotation1
Binding sitei101CitrullineUniRule annotation1
Binding sitei126ATP; via amide nitrogenUniRule annotation1
Binding sitei128AspartateUniRule annotation1
Binding sitei132AspartateUniRule annotation1
Binding sitei132CitrullineUniRule annotation1
Binding sitei133AspartateUniRule annotation1
Binding sitei136CitrullineUniRule annotation1
Binding sitei187CitrullineUniRule annotation1
Binding sitei196CitrullineUniRule annotation1
Binding sitei272CitrullineUniRule annotation1
Binding sitei284CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 24ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processAmino-acid biosynthesis, Arginine biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00068;UER00113

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotationSAAS annotation (EC:6.3.4.5UniRule annotationSAAS annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:Mext_2293Imported
OrganismiMethylobacterium extorquens (strain PA1) (Methylorubrum extorquens)Imported
Taxonomic identifieri419610 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylorubrum
Proteomesi
  • UP000008546 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi419610.Mext_2293

Structurei

3D structure databases

ProteinModelPortaliA9W532
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CDH Bacteria
COG0137 LUCA
HOGENOMiHOG000230093
KOiK01940
OMAiPAREWGM
OrthoDBiPOG091H01U0

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di3.40.50.620, 1 hit
3.90.1260.10, 1 hit
HAMAPiMF_00005 Arg_succ_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

A9W532-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDALPNKSV KKVVLAYSGG LDTSIILKWL QTTYGCEVVT FTADLGQGEE
60 70 80 90 100
LEPARRKAEL LGIKPENIFI EDLREEFVRD YVFPMFRANA VYEGIYLLGT
110 120 130 140 150
SIARPLIAKK QIEIAERVGA DAVCHGATGK GNDQVRFELG YYALKPDVTV
160 170 180 190 200
IAPWREWDLR SREQLIAFAE QHQIPIAKDK RGESPFSVDA NLLHASSEGK
210 220 230 240 250
VLEDPAVEVP DYVYSRTLSP EEAPDTPTIV TIGFERGDAV SIDGEALSPA
260 270 280 290 300
TLLAKLNELG HANGIGRLDL VENRFVGMKS RGMYETPGGT ILLPAHRAIE
310 320 330 340 350
SITLDRGAAH LKDQLMPQYA ELIYNGFWFS PEREMLQALI DKSQEKVTGE
360 370 380 390 400
VRLKLYKGGV HVIGRTSPHS LYDQDLVTFE EGAVAYDHRD AAGFIKLNAL
410
RLRTLAQRKK REG
Length:413
Mass (Da):45,882
Last modified:February 5, 2008 - v1
Checksum:i97F3A4399CD8A465
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000908 Genomic DNA Translation: ABY30688.1
RefSeqiWP_003604474.1, NC_010172.1

Genome annotation databases

EnsemblBacteriaiABY30688; ABY30688; Mext_2293
KEGGimex:Mext_2293

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000908 Genomic DNA Translation: ABY30688.1
RefSeqiWP_003604474.1, NC_010172.1

3D structure databases

ProteinModelPortaliA9W532
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi419610.Mext_2293

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABY30688; ABY30688; Mext_2293
KEGGimex:Mext_2293

Phylogenomic databases

eggNOGiENOG4105CDH Bacteria
COG0137 LUCA
HOGENOMiHOG000230093
KOiK01940
OMAiPAREWGM
OrthoDBiPOG091H01U0

Enzyme and pathway databases

UniPathwayi
UPA00068;UER00113

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di3.40.50.620, 1 hit
3.90.1260.10, 1 hit
HAMAPiMF_00005 Arg_succ_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA9W532_METEP
AccessioniPrimary (citable) accession number: A9W532
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 7, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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