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Protein

Malate dehydrogenase

Gene

mdh

Organism
Methylobacterium extorquens (strain PA1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NADUniRule annotation1
Binding sitei83SubstrateUniRule annotation1
Binding sitei89SubstrateUniRule annotation1
Binding sitei96NADUniRule annotation1
Binding sitei121SubstrateUniRule annotation1
Binding sitei152SubstrateUniRule annotation1
Active sitei176Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15NADUniRule annotation6
Nucleotide bindingi119 – 121NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:Mext_1643
OrganismiMethylobacterium extorquens (strain PA1)
Taxonomic identifieri419610 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
Proteomesi
  • UP000008546 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001261381 – 320Malate dehydrogenaseAdd BLAST320

Interactioni

Protein-protein interaction databases

STRINGi419610.Mext_1643

Structurei

Secondary structure

1320
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 9Combined sources5
Helixi13 – 24Combined sources12
Beta strandi29 – 33Combined sources5
Beta strandi35 – 38Combined sources4
Helixi39 – 54Combined sources16
Beta strandi60 – 65Combined sources6
Helixi66 – 69Combined sources4
Beta strandi73 – 77Combined sources5
Helixi89 – 110Combined sources22
Beta strandi115 – 118Combined sources4
Helixi123 – 134Combined sources12
Helixi138 – 140Combined sources3
Beta strandi141 – 143Combined sources3
Helixi146 – 161Combined sources16
Helixi165 – 167Combined sources3
Beta strandi172 – 174Combined sources3
Helixi177 – 179Combined sources3
Beta strandi180 – 182Combined sources3
Helixi184 – 186Combined sources3
Helixi194 – 199Combined sources6
Helixi205 – 216Combined sources12
Helixi218 – 226Combined sources9
Beta strandi227 – 229Combined sources3
Helixi233 – 247Combined sources15
Beta strandi252 – 262Combined sources11
Helixi263 – 265Combined sources3
Beta strandi267 – 278Combined sources12
Beta strandi281 – 285Combined sources5
Helixi292 – 314Combined sources23
Helixi317 – 319Combined sources3

3D structure databases

ProteinModelPortaliA9W386
SMRiA9W386
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
HOGENOMiHOG000213794
KOiK00024
OMAiMDLMQTA
OrthoDBiPOG091H02N6

Family and domain databases

CDDicd01339 LDH-like_MDH, 1 hit
Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00487 Malate_dehydrog_3, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR011275 Malate_DH_type3
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01763 MalateDH_bact, 1 hit

Sequencei

Sequence statusi: Complete.

A9W386-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARSKIALIG AGQIGGTLAH LAGLKELGDV VLFDIVDGVP QGKALDIAES
60 70 80 90 100
APVDGFDAKY SGASDYSAIA GADVVIVTAG VPRKPGMSRD DLIGINLKVM
110 120 130 140 150
EAVGAGIKEH APDAFVICIT NPLDAMVWAL QKFSGLPTNK VVGMAGVLDS
160 170 180 190 200
ARFRHFLAEE FGVSVEDVTA FVLGGHGDDM VPLTRYSTVA GVPLTDLVKL
210 220 230 240 250
GWTTQEKLDA MVERTRKGGG EIVNLLKTGS AFYAPAASAI AMAESYLRDK
260 270 280 290 300
KRVLPCAAYL DGQYGIDGLY VGVPVVIGEN GVERVLEVTF NDDEKAMFEK
310 320
SVNSVKGLIE ACKSVNDKLA
Length:320
Mass (Da):33,647
Last modified:February 5, 2008 - v1
Checksum:iB2CF23AAA0F032EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000908 Genomic DNA Translation: ABY30042.1
RefSeqiWP_003599890.1, NC_010172.1

Genome annotation databases

EnsemblBacteriaiABY30042; ABY30042; Mext_1643
KEGGimex:Mext_1643

Similar proteinsi

Entry informationi

Entry nameiMDH_METEP
AccessioniPrimary (citable) accession number: A9W386
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 5, 2008
Last modified: October 25, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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