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Entry version 71 (07 Nov 2018)
Sequence version 1 (05 Feb 2008)
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Protein
Submitted name:

Predicted protein

Gene

18722

Organism
Monosiga brevicollis (Choanoflagellate)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi394 – 401ATPPROSITE-ProRule annotation8
Nucleotide bindingi1064 – 1071ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATPase activity, coupled to transmembrane movement of substances Source: GO_Central
  • ATP binding Source: UniProtKB-UniRule

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Predicted proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:18722Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMonosiga brevicollis (Choanoflagellate)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri81824 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaChoanoflagellidaCraspedidaSalpingoecidaeMonosiga
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001357 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei28 – 51HelicalSequence analysisAdd BLAST24
Transmembranei85 – 106HelicalSequence analysisAdd BLAST22
Transmembranei158 – 180HelicalSequence analysisAdd BLAST23
Transmembranei186 – 207HelicalSequence analysisAdd BLAST22
Transmembranei263 – 289HelicalSequence analysisAdd BLAST27
Transmembranei301 – 326HelicalSequence analysisAdd BLAST26
Transmembranei692 – 711HelicalSequence analysisAdd BLAST20
Transmembranei750 – 773HelicalSequence analysisAdd BLAST24
Transmembranei835 – 863HelicalSequence analysisAdd BLAST29

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
431895.XP_001745094.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A9UX43

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 327ABC transmembrane type-1InterPro annotationAdd BLAST285
Domaini362 – 584ABC transporterInterPro annotationAdd BLAST223
Domaini730 – 994ABC transmembrane type-1InterPro annotationAdd BLAST265
Domaini1030 – 1264ABC transporterInterPro annotationAdd BLAST235

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0054 Eukaryota
COG1132 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A9UX43

Identification of Orthologs from Complete Genome Data

More...
OMAi
NEWRVDA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR005292 Multidrug-R_assoc
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00957 MRP_assoc_pro, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A9UX43-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPDENAHVLA NRLKSEWRRQ KAKGHDKASL TLALTRAFWA MFAVGGIFKF
60 70 80 90 100
LQDTLSFVSP QLLKYLIRYV NESQFGEAQP VWHGYALAVG MFITAIFQSI
110 120 130 140 150
FLHQYFHRVM KTGMRLRSAI INVVYEKSLH LSNTARQQST TGEIVNLMSV
160 170 180 190 200
DAQRFMDLMG YLQMIWSAPF QIALSLYFLW QLMGPSTLAG LGVMILMIPL
210 220 230 240 250
NGVLAKVTRD LQKKIMKEKD DRIKHMHEIL NGIKILKMYA WERPFAGFIQ
260 270 280 290 300
DIRNRELKIL TKFAYLNAVS SFSWTAAPFL VSLVTFIAYT LSGNTLTAEK
310 320 330 340 350
AFVSLSLFNI LRFPMAMLPM MITSLVEATV SVNRLRTFLL HEETDPSNVI
360 370 380 390 400
RDRMALALPA AVMERGEFSW NKTDVALRNI DLVLHQQEIC MVVGRVGSGK
410 420 430 440 450
SSLCSALLGD MYKHAGRVVL PGKVAYVPQS AWIRNATVRE NILFGKAFDA
460 470 480 490 500
KRYKQVIHAC ALEPDLLILP GGDACEIGDR GVNLSGGQKA RVSLARAVYQ
510 520 530 540 550
DCDVYVLDDP LSAVDTHVAS HIFKLVLGPE GMLRNKARLL VTNALQFMRE
560 570 580 590 600
AQNIVVMNKG EIKEQGTFRE LCDHEGDFKK LMTDFTTGGT GDKPTGSKDA
610 620 630 640 650
GGDVKELGSE STEIESTTDE QRTSSSKSNV ILDSTGTKGS DSALMPVNDK
660 670 680 690 700
TDKAEKSGAA GESATEHSGL IKKEKAQEGN VKLDVYMSYF RAITWPVTIS
710 720 730 740 750
LLAMYVVSYG MQVGSNKWLD VWSSEQDKHD HAVSSNATQV PNVRPVGVYL
760 770 780 790 800
GVYAALGMGN ALGVLFTTLV LAYGSIRASR VMHNDMLLRI VRCPMSFFDT
810 820 830 840 850
TPLGRIVNRF SKDIYVLDET IPRSLRSFMS TFMQVVATIV VISVSTPLFM
860 870 880 890 900
VIILPMSLLY YYVQRYYVAT SRQLQRLESV SRSPIYAHFT ETLHGVSNIR
910 920 930 940 950
AYGKVPDFVQ ENEERVDFNL QAYYPFICAN RWLALRLEFL GNSIIFFAAL
960 970 980 990 1000
FAVIEVEEKS SAISPGTAGL SLSYAMSVTQ TLNWMVRMSS QLETDIVAIE
1010 1020 1030 1040 1050
RVEEYCSVPV EAPPILDHRP KPNWPDQGNI SFDHYCVRYR EGLDLVLREI
1060 1070 1080 1090 1100
SCTIEGGQKI GCVGRTGAGK SSMTLSLLRI LEAAGGRIVI DGENIAKIGL
1110 1120 1130 1140 1150
EDLRSRLTIM PQDPIVFSGT IRQNLDPFKR HTDDELWRAL RTCHLGDKVT
1160 1170 1180 1190 1200
EMEGALDHVV SEGGGNFSLG ERQLLCLSRA VLRKTKVLIL DEATAAVDVE
1210 1220 1230 1240 1250
TDELIQETIR SEFAECTIFT IAHRLNTIMD SDKIMVLDKG KVIEFDSPAA
1260
LLATRTSVFY GMAESANLI
Length:1,269
Mass (Da):141,504
Last modified:February 5, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5AB2991B30DEA17D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH991548 Genomic DNA Translation: EDQ90327.1

NCBI Reference Sequences

More...
RefSeqi
XP_001745094.1, XM_001745042.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EDQ90327; EDQ90327; MONBRDRAFT_18722

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5890145

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mbr:MONBRDRAFT_18722

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH991548 Genomic DNA Translation: EDQ90327.1
RefSeqiXP_001745094.1, XM_001745042.1

3D structure databases

ProteinModelPortaliA9UX43
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi431895.XP_001745094.1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEDQ90327; EDQ90327; MONBRDRAFT_18722
GeneIDi5890145
KEGGimbr:MONBRDRAFT_18722

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
InParanoidiA9UX43
OMAiNEWRVDA

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR005292 Multidrug-R_assoc
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
TIGRFAMsiTIGR00957 MRP_assoc_pro, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA9UX43_MONBE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A9UX43
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 7, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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