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Entry version 77 (05 Jun 2019)
Sequence version 1 (05 Feb 2008)
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Protein
Submitted name:

AP2-associated kinase 1

Gene

aak1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-XTR-8856825 Cargo recognition for clathrin-mediated endocytosis
R-XTR-8856828 Clathrin-mediated endocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
AP2-associated kinase 1Imported
Submitted name:
LOC100135375 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:aak1Imported
Synonyms:LOC100135375Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008143 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-986555 aak1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSXETG00000008205 Expressed in 11 organ(s), highest expression level in blastula

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
8364.ENSXETP00000017987

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini42 – 324Protein kinaseInterPro annotationAdd BLAST283

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni337 – 455DisorderedSequence analysisAdd BLAST119
Regioni525 – 601DisorderedSequence analysisAdd BLAST77
Regioni634 – 671DisorderedSequence analysisAdd BLAST38
Regioni774 – 833DisorderedSequence analysisAdd BLAST60

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi349 – 365PolarSequence analysisAdd BLAST17
Compositional biasi366 – 380Pro-richSequence analysisAdd BLAST15
Compositional biasi422 – 439PolarSequence analysisAdd BLAST18
Compositional biasi525 – 541PolarSequence analysisAdd BLAST17
Compositional biasi561 – 576Pro-richSequence analysisAdd BLAST16
Compositional biasi580 – 596PolarSequence analysisAdd BLAST17
Compositional biasi634 – 660PolarSequence analysisAdd BLAST27
Compositional biasi804 – 823PolyampholyteSequence analysisAdd BLAST20

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1989 Eukaryota
ENOG410Y515 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155968

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000232173

KEGG Orthology (KO)

More...
KOi
K08853

Identification of Orthologs from Complete Genome Data

More...
OMAi
CPVQNVQ

Database of Orthologous Groups

More...
OrthoDBi
826336at2759

TreeFam database of animal gene trees

More...
TreeFami
TF317300

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028182 BMP2K_C
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15282 BMP2K_C, 1 hit
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A9UMJ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKFFDSRRE LVGSGSGVGG GSSSGLGTGY IGRVFTIGRH QVTVDEVLAE
60 70 80 90 100
GGFALVFLVR TSNGMRRALK RMYVNNEHDL QVCKREIQIM RDLSGHKNIV
110 120 130 140 150
GYIDSSINSV SSGDVWEVLI LMDYCRGGQV VNLMNQRLQT GFTESEVLQI
160 170 180 190 200
FCDTCEAVAR LHQCKTPIIH RDLKVENILL HDRGHYVLCD FGSATNKCQN
210 220 230 240 250
PQTEGVTAVE DEIKKYTTLS YRAPEMVNLY SGKMITTKAD IWALGCLLYK
260 270 280 290 300
LCFFTLPFGE SQVSICDGNF TIPDNSRYSQ DMHCLIRYML EPDPDKRPDI
310 320 330 340 350
YQVSYFSFKL AKRECPVQNV HDAVIPVKLP EPIKAGEAAA KKTQPKARLT
360 370 380 390 400
DPVPTTETSI APRQRPKPGQ PQPNPGMLPI QPALTPRKRA MAQPANPSPV
410 420 430 440 450
APVSIQSPNP AAVAPAVRPS VQTQPKAAQP AAQVPTPVTT TPQPATPQAP
460 470 480 490 500
PAAVQSALTQ QQQQLYLKQQ LMQQQQQQAA AYYQQQQQQQ MLQAQQIQAM
510 520 530 540 550
QQQQMLQAYY MQQQHLLAQH AAMQQKVATP KQSSLPSQPQ AMPAALQPPA
560 570 580 590 600
AQEQGQPAPL KTPQKPQPPT APPSSAPPTA AGQKLGSLTP PSSPKTQRGG
610 620 630 640 650
HRRILSDVTH SAVFGVPASK STQLLQAAAA EANLNKSKSA TTTPSGSPRT
660 670 680 690 700
SQQNVHNPPE PSGWNPFDDD NFSKLTAEEL LNKDFAKLGE SKPSEQLSRS
710 720 730 740 750
AEDLLSGFPA PPAVSQADSF GTALFASGSG VHQDMKVFPP GSDGHIKMHS
760 770 780 790 800
GGDYPLAADN KHFLEMKNEC PSKGPSSCSS FHSSDGEATD HDPDLLDCSG
810 820 830 840 850
SRPLLMESDD DECSRKTKDL EVPSPPIDEI STQNSQLPFH NVNSWRPELS
860 870 880 890 900
LAEGFDVFST APFKGPKLTQ DESEIFTNAP FVAKTAFPSF QSQEPDVFLR
910 920 930 940 950
APFSRKLSTE EASQNISSQS FSSLLGLDVV GNSTFRNSEM AVGSSSMKTS
960 970 980 990 1000
YTTGNLYSHS IRPLESADSS IFTNTSMEPG IIENHMLPGH EAAQETVFGT
1010 1020 1030 1040 1050
VVTKPFRPQS LSKYSRHYSP QDGRNVDAQP IAAFKVVSKS ANTSVAGSVP
1060 1070 1080
ISSVTYRTSE ITNVDPFGSA PFPAKASRPK P
Length:1,081
Mass (Da):117,501
Last modified:February 5, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9CFEDDFA07834D0C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6QZV5F6QZV5_XENTR
AP2-associated kinase 1
aak1
1,070Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAMC01044555 Genomic DNA No translation available.
AAMC01044556 Genomic DNA No translation available.
BC157684 mRNA Translation: AAI57685.1
BC171117 mRNA Translation: AAI71117.1
BC171121 mRNA Translation: AAI71121.1

NCBI Reference Sequences

More...
RefSeqi
NP_001107518.1, NM_001114046.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSXETT00000017987; ENSXETP00000017987; ENSXETG00000008205

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100135375

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xtr:100135375

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01044555 Genomic DNA No translation available.
AAMC01044556 Genomic DNA No translation available.
BC157684 mRNA Translation: AAI57685.1
BC171117 mRNA Translation: AAI71117.1
BC171121 mRNA Translation: AAI71121.1
RefSeqiNP_001107518.1, NM_001114046.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000017987

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000017987; ENSXETP00000017987; ENSXETG00000008205
GeneIDi100135375
KEGGixtr:100135375

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22848
XenbaseiXB-GENE-986555 aak1

Phylogenomic databases

eggNOGiKOG1989 Eukaryota
ENOG410Y515 LUCA
GeneTreeiENSGT00940000155968
HOGENOMiHOG000232173
KOiK08853
OMAiCPVQNVQ
OrthoDBi826336at2759
TreeFamiTF317300

Enzyme and pathway databases

ReactomeiR-XTR-8856825 Cargo recognition for clathrin-mediated endocytosis
R-XTR-8856828 Clathrin-mediated endocytosis

Gene expression databases

BgeeiENSXETG00000008205 Expressed in 11 organ(s), highest expression level in blastula

Family and domain databases

InterProiView protein in InterPro
IPR028182 BMP2K_C
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF15282 BMP2K_C, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA9UMJ8_XENTR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A9UMJ8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: June 5, 2019
This is version 77 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
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