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Protein
Submitted name:

Platelet-derived growth factor subunit B

Gene

PDGFB

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionGrowth factorUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Platelet-derived growth factor subunit BImported
Gene namesi
Name:PDGFBImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100311.16
HGNCiHGNC:8800 PDGFB

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100311

PTM / Processingi

Proteomic databases

PeptideAtlasiA9UJP0
PRIDEiA9UJP0

Expressioni

Gene expression databases

BgeeiENSG00000100311 Expressed in 215 organ(s), highest expression level in placenta
ExpressionAtlasiA9UJP0 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA9UJP0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 144PDGF_2InterPro annotationAdd BLAST95

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IJ45 Eukaryota
ENOG410XWTB LUCA
GeneTreeiENSGT00510000046755
HOGENOMiHOG000286027
HOVERGENiHBG053546

Family and domain databases

CDDicd00135 PDGF, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR023581 PD_growth_factor_CS
IPR000072 PDGF/VEGF_dom
IPR015583 PDGF_suB
PANTHERiPTHR11633:SF2 PTHR11633:SF2, 1 hit
PfamiView protein in Pfam
PF00341 PDGF, 1 hit
SMARTiView protein in SMART
SM00141 PDGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00249 PDGF_1, 1 hit
PS50278 PDGF_2, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A9UJP0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSDHSIRSF DDLQRLLHGD PGEEDGAELD LNMTRSHSGG ELESLARGRR
60 70 80 90 100
SLGSLTIAEP AMIAECKTRT EVFEISRRLI DRTNANFLVW PPCVEVQRCS
110 120 130 140
GCCNNRNVQC RPTQVQLRPV QVRKIEIVRK KPIFKKATVT LEDH
Length:144
Mass (Da):16,340
Last modified:February 5, 2008 - v1
Checksum:i6C6023EA3DBC3BC2
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P01127PDGFB_HUMAN
Platelet-derived growth factor subu...
PDGFB PDGF2, SIS
241Annotation score:
A9UJN9A9UJN9_HUMAN
Platelet-derived growth factor subu...
PDGFB
136Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei144Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81010 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000455790; ENSP00000402306; ENSG00000100311
UCSCiuc062eka.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81010 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliA9UJP0
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiA9UJP0
PRIDEiA9UJP0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000455790; ENSP00000402306; ENSG00000100311
UCSCiuc062eka.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000100311.16
HGNCiHGNC:8800 PDGFB
OpenTargetsiENSG00000100311
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ45 Eukaryota
ENOG410XWTB LUCA
GeneTreeiENSGT00510000046755
HOGENOMiHOG000286027
HOVERGENiHBG053546

Miscellaneous databases

ChiTaRSiPDGFB human

Gene expression databases

BgeeiENSG00000100311 Expressed in 215 organ(s), highest expression level in placenta
ExpressionAtlasiA9UJP0 baseline and differential

Family and domain databases

CDDicd00135 PDGF, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR023581 PD_growth_factor_CS
IPR000072 PDGF/VEGF_dom
IPR015583 PDGF_suB
PANTHERiPTHR11633:SF2 PTHR11633:SF2, 1 hit
PfamiView protein in Pfam
PF00341 PDGF, 1 hit
SMARTiView protein in SMART
SM00141 PDGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00249 PDGF_1, 1 hit
PS50278 PDGF_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA9UJP0_HUMAN
AccessioniPrimary (citable) accession number: A9UJP0
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 12, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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