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Protein
Submitted name:

BCR/ABL fusion protein isoform X9

Gene

BCR/ABL fusion

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiA9UF02

Names & Taxonomyi

Protein namesi
Submitted name:
BCR/ABL fusion protein isoform X9Imported
Gene namesi
Name:BCR/ABL fusionImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Chemistry databases

DrugBankiDB00619 Imatinib

PTM / Processingi

Proteomic databases

PeptideAtlasiA9UF02
PRIDEiA9UF02

PTM databases

iPTMnetiA9UF02

Interactioni

Protein-protein interaction databases

ELMiA9UF02

Structurei

3D structure databases

ProteinModelPortaliA9UF02
SMRiA9UF02
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini575 – 635SH3InterPro annotationAdd BLAST61
Domaini641 – 731SH2InterPro annotationAdd BLAST91
Domaini756 – 1007Protein kinaseInterPro annotationAdd BLAST252

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili28 – 55Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
HOVERGENiHBG004162

Family and domain databases

CDDicd09935 SH2_ABL, 1 hit
Gene3Di3.30.505.10, 1 hit
4.10.280.30, 1 hit
InterProiView protein in InterPro
IPR033221 ABL1
IPR035837 ABL_SH2
IPR015123 Bcr-Abl_oncoprot_oligo
IPR036481 Bcr-Abl_oncoprot_oligo_sf
IPR015015 F-actin_binding
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PANTHERiPTHR24418:SF88 PTHR24418:SF88, 1 hit
PfamiView protein in Pfam
PF09036 Bcr-Abl_Oligo, 1 hit
PF08919 F_actin_bind, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF00017 SH2, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00808 FABD, 1 hit
SM00252 SH2, 1 hit
SM00326 SH3, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 1 hit
SSF69036 SSF69036, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50001 SH2, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

A9UF02-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDPVGFAEA WKAQFPDSEP PRMELRSVGD IEQELERCKA SIRRLEQEVN
60 70 80 90 100
QERFRMIYLQ TLLAKEKKSY DRQRWGFRRA AQAPDGASEP RASASRPQPA
110 120 130 140 150
PADGADPPPA EEPEARPDGE GSPGKARPGT ARRPGAAASG ERDDRGPPAS
160 170 180 190 200
VAALRSNFER IRKGHGQPGA DAEKPFYVNV EFHHERGLVK VNDKEVSDRI
210 220 230 240 250
SSLGSQAMQM ERKKSQHGAG SSVGDASRPP YRGRSSESSC GVDGDYEDAE
260 270 280 290 300
LNPRFLKDNL IDANGGSRPP WPPLEYQPYQ SIYVGGMMEG EGKGPLLRSQ
310 320 330 340 350
STSEQEKRLT WPRRSYSPRS FEDCGGGYTP DCSSNENLTS SEEDFSSGQS
360 370 380 390 400
SRVSPSPTTY RMFRDKSRSP SQNSQQSFDS SSPPTPQCHK RHRHCPVVVS
410 420 430 440 450
EATIVGVRKT GQIWPNDGEG AFHGDADGSF GTPPGYGCAA DRAEEQRRHQ
460 470 480 490 500
DGLPYIDDSP SSSPHLSSKG RGSRDALVSG ALESTKASEL DLEKGLEMRK
510 520 530 540 550
WVLSGILASE ETYLSHLQML TNSCVKLQTV HSIPLTINKE EALQRPVASD
560 570 580 590 600
FEPQGLSEAA RWNSKENLLA GPSENDPNLF VALYDFVASG DNTLSITKGE
610 620 630 640 650
KLRVLGYNHN GEWCEAQTKN GQGWVPSNYI TPVNSLEKHS WYHGPVSRNA
660 670 680 690 700
AEYLLSSGIN GSFLVRESES SPGQRSISLR YEGRVYHYRI NTASDGKLYV
710 720 730 740 750
SSESRFNTLA ELVHHHSTVA DGLITTLHYP APKRNKPTVY GVSPNYDKWE
760 770 780 790 800
MERTDITMKH KLGGGQYGEV YEGVWKKYSL TVAVKTLKED TMEVEEFLKE
810 820 830 840 850
AAVMKEIKHP NLVQLLGVCT REPPFYIITE FMTYGNLLDY LRECNRQEVN
860 870 880 890 900
AVVLLYMATQ ISSAMEYLEK KNFIHRDLAA RNCLVGENHL VKVADFGLSR
910 920 930 940 950
LMTGDTYTAH AGAKFPIKWT APESLAYNKF SIKSDVWAFG VLLWEIATYG
960 970 980 990 1000
MSPYPGIDLS QVYELLEKDY RMERPEGCPE KVYELMRACW QWNPSDRPSF
1010 1020 1030 1040 1050
AEIHQAFETM FQESSISDEV EKELGKQGVR GAVSTLLQAP ELPTKTRTSR
1060 1070 1080 1090 1100
RAAEHRDTTD VPEMPHSKGQ GESDPLDHEP AVSPLLPRKE RGPPEGGLNE
1110 1120 1130 1140 1150
DERLLPKDKK TNLFSALIKK KKKTAPTPPK RSSSFREMDG QPERRGAGEE
1160 1170 1180 1190 1200
EGRDISNGAL AFTPLDTADP AKSPKPSNGA GVPNGALRES GGSGFRSPHL
1210 1220 1230 1240 1250
WKKSSTLTSS RLATGEEEGG GSSSKRFLRS CSASCVPHGA KDTEWRSVTL
1260 1270 1280 1290 1300
PRDLQSTGRQ FDSSTFGGHK SEKPALPRKR AGENRSDQVT RGTVTPPPRL
1310 1320 1330 1340 1350
VKKNEEAADE VFKDIMESSP GSSPPNLTPK PLRRQVTVAP ASGLPHKEEA
1360 1370 1380 1390 1400
GKGSALGTPA AAEPVTPTSK AGSGAPGGTS KGPAEESRVR RHKHSSESPG
1410 1420 1430 1440 1450
RDKGKLSRLK PAPPPPPAAS AGKAGGKPSQ SPSQEAAGEA VLGAKTKATS
1460 1470 1480 1490 1500
LVDAVNSDAA KPSQPGEGLK KPVLPATPKP QSAKPSGTPI SPAPVPSTLP
1510 1520 1530 1540 1550
SASSALAGDQ PSSTAFIPLI STRVSLRKTR QPPERIASGA ITKGVVLDST
1560 1570 1580 1590 1600
EALCLAISRN SEQMASHSAV LEAGKNLYTF CVSYVDSIQQ MRNKFAFREA
1610 1620 1630 1640
INKLENNLRE LQICPATAGS GPAATQDFSK LLSSVKEISD IVQR
Length:1,644
Mass (Da):179,323
Last modified:February 5, 2008 - v1
Checksum:iEAF7473B10174EB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU216066 mRNA Translation: ABX82708.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU216066 mRNA Translation: ABX82708.1

3D structure databases

ProteinModelPortaliA9UF02
SMRiA9UF02
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ELMiA9UF02

Chemistry databases

DrugBankiDB00619 Imatinib

PTM databases

iPTMnetiA9UF02

Proteomic databases

PeptideAtlasiA9UF02
PRIDEiA9UF02

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
HOVERGENiHBG004162

Enzyme and pathway databases

SignaLinkiA9UF02

Miscellaneous databases

ChiTaRSiABL1 human

Family and domain databases

CDDicd09935 SH2_ABL, 1 hit
Gene3Di3.30.505.10, 1 hit
4.10.280.30, 1 hit
InterProiView protein in InterPro
IPR033221 ABL1
IPR035837 ABL_SH2
IPR015123 Bcr-Abl_oncoprot_oligo
IPR036481 Bcr-Abl_oncoprot_oligo_sf
IPR015015 F-actin_binding
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PANTHERiPTHR24418:SF88 PTHR24418:SF88, 1 hit
PfamiView protein in Pfam
PF09036 Bcr-Abl_Oligo, 1 hit
PF08919 F_actin_bind, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF00017 SH2, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00808 FABD, 1 hit
SM00252 SH2, 1 hit
SM00326 SH3, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 1 hit
SSF69036 SSF69036, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50001 SH2, 1 hit
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA9UF02_HUMAN
AccessioniPrimary (citable) accession number: A9UF02
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: October 10, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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