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Protein

5'/3'-nucleotidase SurE

Gene

surE

Organism
Yersinia pestis bv. Antiqua (strain Angola)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.UniRule annotation

Catalytic activityi

A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.UniRule annotation
A 3'-ribonucleotide + H2O = a ribonucleoside + phosphate.UniRule annotation
(Polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate.UniRule annotation

Cofactori

a divalent metal cationUniRule annotationNote: Binds 1 divalent metal cation per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9Divalent metal cationUniRule annotation1
Metal bindingi10Divalent metal cationUniRule annotation1
Metal bindingi40Divalent metal cationUniRule annotation1
Metal bindingi93Divalent metal cationUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
5'/3'-nucleotidase SurEUniRule annotation (EC:3.1.3.5UniRule annotation, EC:3.1.3.6UniRule annotation)
Alternative name(s):
ExopolyphosphataseUniRule annotation (EC:3.6.1.11UniRule annotation)
Nucleoside monophosphate phosphohydrolaseUniRule annotation
Gene namesi
Name:surEUniRule annotation
Ordered Locus Names:YpAngola_A0961
OrganismiYersinia pestis bv. Antiqua (strain Angola)
Taxonomic identifieri349746 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000920521 – 2545'/3'-nucleotidase SurEAdd BLAST254

Structurei

3D structure databases

ProteinModelPortaliA9R116
SMRiA9R116
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SurE nucleotidase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000122500
KOiK03787
OMAiDCVHIAL

Family and domain databases

Gene3Di3.40.1210.10, 1 hit
HAMAPiMF_00060 SurE, 1 hit
InterProiView protein in InterPro
IPR030048 SurE
IPR002828 SurE-like_Pase/nucleotidase
IPR036523 SurE-like_sf
PfamiView protein in Pfam
PF01975 SurE, 1 hit
TIGRFAMsiTIGR00087 surE, 1 hit

Sequencei

Sequence statusi: Complete.

A9R116-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRILLSNDD GISAPGIQTL ASALRGFAQV QIVAPDRNRS GASNALTLDS
60 70 80 90 100
ALRITTLSNG DIAVQQGTPT DCVYLGVNAL MRPRPDIVVS GINAGPNLGD
110 120 130 140 150
DVIYSGTVAA AMEGRHLGYP ALAVSLNGHQ HYDTAAAVTC RLLRALQRKP
160 170 180 190 200
LRTGKILNIN VPDLPLAEIK GIRVTRCGSR HPAEQVFCQQ DPRGQDLYWI
210 220 230 240 250
GPPGEKYDAG PDTDFAAVEQ GYVSITPLQV DLTAYMAQEV VESWLANTEV

DGEW
Length:254
Mass (Da):27,231
Last modified:February 5, 2008 - v1
Checksum:i99C139F3E5D4E4F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000901 Genomic DNA Translation: ABX85503.1
RefSeqiWP_002209394.1, NZ_CP009935.1

Genome annotation databases

EnsemblBacteriaiABX85503; ABX85503; YpAngola_A0961
KEGGiypg:YpAngola_A0961
PATRICifig|349746.12.peg.1909

Similar proteinsi

Entry informationi

Entry nameiSURE_YERPG
AccessioniPrimary (citable) accession number: A9R116
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 5, 2008
Last modified: February 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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