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Protein

Molybdenum cofactor guanylyltransferase

Gene

mobA

Organism
Yersinia pestis bv. Antiqua (strain Angola)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.UniRule annotation

Catalytic activityi

GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei23GTPUniRule annotation1
Binding sitei51GTPUniRule annotation1
Binding sitei69GTPUniRule annotation1
Metal bindingi99MagnesiumUniRule annotation1
Binding sitei99GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 12GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processMolybdenum cofactor biosynthesis
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdenum cofactor guanylyltransferaseUniRule annotation (EC:2.7.7.77UniRule annotation)
Short name:
MoCo guanylyltransferaseUniRule annotation
Alternative name(s):
GTP:molybdopterin guanylyltransferaseUniRule annotation
Mo-MPT guanylyltransferaseUniRule annotation
Molybdopterin guanylyltransferaseUniRule annotation
Molybdopterin-guanine dinucleotide synthaseUniRule annotation
Short name:
MGD synthaseUniRule annotation
Gene namesi
Name:mobAUniRule annotation
Ordered Locus Names:YpAngola_A0019
OrganismiYersinia pestis bv. Antiqua (strain Angola)
Taxonomic identifieri349746 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001158121 – 195Molybdenum cofactor guanylyltransferaseAdd BLAST195

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA9QYH5
SMRiA9QYH5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.UniRule annotation

Sequence similaritiesi

Belongs to the MobA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000280423
KOiK03752
OMAiFVPCDVP

Family and domain databases

CDDicd02503 MobA, 1 hit
Gene3Di3.90.550.10, 1 hit
HAMAPiMF_00316 MobA, 1 hit
InterProiView protein in InterPro
IPR025877 MobA-like_NTP_Trfase
IPR013482 Molybde_CF_guanTrfase
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF12804 NTP_transf_3, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR02665 molyb_mobA, 1 hit

Sequencei

Sequence statusi: Complete.

A9QYH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPNITGVIL AGGRSSRMGG NDKGLIPLNG KPLFQYVIDR FKPQVSDLVI
60 70 80 90 100
NANRNQGLYK ESGIPVIDDI ITGFVGPLAG MHAGLSYAST EWVVFAPCDV
110 120 130 140 150
PALPSDLVSQ LWQGKKQALA AYANDDERAH PTFALMHISL KTQLADYLIR
160 170 180 190
GDRKLMLFLD SINAQRVKFS GKADLFSNLN TPADCDLWEQ KRRGQ
Length:195
Mass (Da):21,445
Last modified:February 5, 2008 - v1
Checksum:i9F85C6684B2FC127
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000901 Genomic DNA Translation: ABX86890.1

Genome annotation databases

EnsemblBacteriaiABX86890; ABX86890; YpAngola_A0019
KEGGiypg:YpAngola_A0019
PATRICifig|349746.12.peg.963

Similar proteinsi

Entry informationi

Entry nameiMOBA_YERPG
AccessioniPrimary (citable) accession number: A9QYH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 5, 2008
Last modified: October 25, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health