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Protein

Importin subunit alpha-8

Gene

KPNA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions in nuclear protein import.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
R-HSA-168276 NS1 Mediated Effects on Host Pathways
SignaLinkiA9QM74

Names & Taxonomyi

Protein namesi
Recommended name:
Importin subunit alpha-8
Alternative name(s):
Karyopherin subunit alpha-7
Gene namesi
Name:KPNA7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000185467.7
HGNCiHGNC:21839 KPNA7
MIMi614107 gene
neXtProtiNX_A9QM74

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi402569
MalaCardsiKPNA7
OpenTargetsiENSG00000185467
Orphaneti401959 Partial corpus callosum agenesis-cerebellar vermis hypoplasia with posterior fossa cysts syndrome
PharmGKBiPA164722048

Polymorphism and mutation databases

BioMutaiKPNA7

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003260821 – 516Importin subunit alpha-8Add BLAST516

Proteomic databases

MaxQBiA9QM74
PaxDbiA9QM74
PRIDEiA9QM74
ProteomicsDBi2499

PTM databases

iPTMnetiA9QM74
PhosphoSitePlusiA9QM74

Expressioni

Gene expression databases

BgeeiENSG00000185467

Organism-specific databases

HPAiHPA031395

Interactioni

Subunit structurei

Binds very efficiently to importin subunit beta-1/KPNB1 via the IBB domain; this complex dissociates in the presence of RAN-GTP. Shows a limited binding to the RB1 nuclear localization signal (NLS), but not to the SV40, nor NPM1 NLSs.

Binary interactionsi

WithEntry#Exp.IntActNotes
KPNB1Q149742EBI-13942676,EBI-286758

Protein-protein interaction databases

BioGridi135514, 3 interactors
ComplexPortaliCPX-1066 Importin complex, KPNA7 variant
IntActiA9QM74, 1 interactor
STRINGi9606.ENSP00000330878

Structurei

3D structure databases

ProteinModelPortaliA9QM74
SMRiA9QM74
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 57IBBPROSITE-ProRule annotationAdd BLAST57
Repeati103 – 143ARM 1Add BLAST41
Repeati146 – 185ARM 2Add BLAST40
Repeati188 – 228ARM 3Add BLAST41
Repeati231 – 270ARM 4Add BLAST40
Repeati273 – 312ARM 5Add BLAST40
Repeati315 – 354ARM 6Add BLAST40
Repeati357 – 396ARM 7Add BLAST40
Repeati400 – 439ARM 8Add BLAST40

Sequence similaritiesi

Belongs to the importin alpha family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0166 Eukaryota
COG5064 LUCA
GeneTreeiENSGT00760000119094
HOGENOMiHOG000167616
HOVERGENiHBG001846
InParanoidiA9QM74
OMAiNKNPYPC
OrthoDBiEOG091G095Z
PhylomeDBiA9QM74
TreeFamiTF101178

Family and domain databases

Gene3Di1.20.5.690, 1 hit
1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR032413 Arm_3
IPR000225 Armadillo
IPR002652 Importin-a_IBB
IPR036975 Importin-a_IBB_sf
IPR024931 Importing_su_alpha
PfamiView protein in Pfam
PF00514 Arm, 7 hits
PF16186 Arm_3, 1 hit
PF01749 IBB, 1 hit
PIRSFiPIRSF005673 Importin_alpha, 1 hit
SMARTiView protein in SMART
SM00185 ARM, 8 hits
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 5 hits
PS51214 IBB, 1 hit

Sequencei

Sequence statusi: Complete.

A9QM74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTLDAPEER RRKFKYRGKD VSLRRQQRMA VSLELRKAKK DEQTLKRRNI
60 70 80 90 100
TSFCPDTPSE KTAKGVAVSL TLGEIIKGVN SSDPVLCFQA TQTARKMLSQ
110 120 130 140 150
EKNPPLKLVI EAGLIPRMVE FLKSSLYPCL QFEAAWALTN IASGTSEQTR
160 170 180 190 200
AVVEGGAIQP LIELLSSSNV AVCEQAVWAL GNIAGDGPEF RDNVITSNAI
210 220 230 240 250
PHLLALISPT LPITFLRNIT WTLSNLCRNK NPYPCDTAVK QILPALLHLL
260 270 280 290 300
QHQDSEVLSD ACWALSYLTD GSNKRIGQVV NTGVLPRLVV LMTSSELNVL
310 320 330 340 350
TPSLRTVGNI VTGTDEQTQM AIDAGMLNVL PQLLQHNKPS IQKEAAWALS
360 370 380 390 400
NVAAGPCHHI QQLLAYDVLP PLVALLKNGE FKVQKEAVWM VANFATGATM
410 420 430 440 450
DQLIQLVHSG VLEPLVNLLT APDVKIVLII LDVISCILQA AEKRSEKENL
460 470 480 490 500
CLLIEELGGI DRIEALQLHE NRQIGQSALN IIEKHFGEEE DESQTLLSQV
510
IDQDYEFIDY ECLAKK
Length:516
Mass (Da):56,938
Last modified:February 5, 2008 - v1
Checksum:i803D7CC662C09378
GO

Sequence cautioni

The sequence EAL23884 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU126604 mRNA Translation: ABW96272.1
CH236956 Genomic DNA Translation: EAL23884.1 Different initiation.
CCDSiCCDS47651.1
RefSeqiNP_001139187.1, NM_001145715.2
UniGeneiHs.253050

Genome annotation databases

EnsembliENST00000327442; ENSP00000330878; ENSG00000185467
ENST00000640158; ENSP00000491331; ENSG00000284068
GeneIDi402569
KEGGihsa:402569
UCSCiuc010lft.3 human

Similar proteinsi

Entry informationi

Entry nameiIMA8_HUMAN
AccessioniPrimary (citable) accession number: A9QM74
Secondary accession number(s): A4D277
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: February 5, 2008
Last modified: June 20, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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