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UniProtKB - A9Q751 (PCDP1_MOUSE)
Protein
Cilia- and flagella-associated protein 221
Gene
Cfap221
Organism
Mus musculus (Mouse)
Status
Functioni
May play a role in cilium morphogenesis.
1 PublicationGO - Molecular functioni
- calmodulin binding Source: UniProtKB
GO - Biological processi
- cerebrospinal fluid circulation Source: MGI
- motile cilium assembly Source: MGI
- mucociliary clearance Source: MGI
Keywordsi
Molecular function | Calmodulin-binding |
Biological process | Cilium biogenesis/degradation |
Names & Taxonomyi
Protein namesi | Recommended name: Cilia- and flagella-associated protein 221ImportedAlternative name(s): Primary ciliary dyskinesia protein 11 Publication |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2684947, Cfap221 |
VEuPathDBi | HostDB:ENSMUSG00000036962 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytoskeleton
- cilium axoneme 1 Publication
Cytoskeleton
- axoneme Source: UniProtKB
Extracellular region or secreted
- extracellular region Source: GOC
Other locations
- 9+2 motile cilium Source: MGI
- sperm flagellum Source: MGI
Keywords - Cellular componenti
Cell projection, Cilium, Cytoplasm, CytoskeletonPathology & Biotechi
Disruption phenotypei
Mice lacking Pcdp1 have several phenotypes associated with primary ciliary diskinesia, including hydrocephalus, male infertility and respiratory abnormalities. Hydrocephalus is observed on the B6 background but not on the 129 background. Male infertility is observed on both backgrounds and is due to an absence of mature spermatozoa in the seminiferous tubules.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000395000 | 1 – 836 | Cilia- and flagella-associated protein 221Add BLAST | 836 |
Proteomic databases
PaxDbi | A9Q751 |
PRIDEi | A9Q751 |
ProteomicsDBi | 289326 |
PTM databases
iPTMneti | A9Q751 |
PhosphoSitePlusi | A9Q751 |
Expressioni
Tissue specificityi
Expressed in testis, specifically in developing spermatocytes and spermatids but not in immature spermatogonia. Expressed in the ciliated respiratory epithelial cells lining the sinuses, trachea and bronchi (at protein level).2 Publications
Developmental stagei
Expression in testis starts at P20.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000036962, Expressed in testis and 67 other tissues |
Genevisiblei | A9Q751, MM |
Interactioni
Subunit structurei
Interacts with calmodulin; calcium-dependent.
1 PublicationGO - Molecular functioni
- calmodulin binding Source: UniProtKB
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000134576 |
Miscellaneous databases
RNActi | A9Q751, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 466 – 500 | Interaction with calmodulin1 PublicationAdd BLAST | 35 |
Sequence similaritiesi
Belongs to the PCDP1 family.Curated
Phylogenomic databases
eggNOGi | ENOG502QT0T, Eukaryota |
GeneTreei | ENSGT00390000006925 |
HOGENOMi | CLU_020964_0_0_1 |
InParanoidi | A9Q751 |
OMAi | IQVEFPM |
OrthoDBi | 1411975at2759 |
PhylomeDBi | A9Q751 |
TreeFami | TF328807 |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR029676, Gm101 IPR013783, Ig-like_fold |
PANTHERi | PTHR46500, PTHR46500, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
A9Q751-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEVVKSPMQE LQQAKEPFDT MSPLLLKSLV EEPKKRTEVP NHLLESRVYA
60 70 80 90 100
KLLNNKVIQA RPGIVHFGGY EIESKHQQIL NIANISDEDT HLHILPPQTK
110 120 130 140 150
YFQINFEKKE HRLIPGLSLT VTITFSPDEW RYYYDCIRIH CKGDDTLLVP
160 170 180 190 200
IHAYPVLNNL DFPTFINLSD VFLGESKSYV IPLQCSCPVD FEFHITLLRS
210 220 230 240 250
HQAFTIEPKS GIIPANGKAK VTVKFTPIQY GMAQIKIQLW ISQFNSQPYE
260 270 280 290 300
CVFTGTCYPN MALPLEEFKR LNTRSKKVNV PLEKTTYVQF YPAPAKAKPQ
310 320 330 340 350
KLKEIDYQDL RFPADLSNPF AVATVLNQEP GKLKIKELKQ VLDQGDEISK
360 370 380 390 400
TRQMKEAIFE QKVRQDILTE IENHLKWQVH LGKEHTTYRF KRELTEEWKK
410 420 430 440 450
ARAKYKQNRG DPVEGEELQR LQTEQSQKRI VRDLKGKRQE FHPNFDPLVN
460 470 480 490 500
NVWLTRHRAQ RRFQQAARKI MLERRLLSML GAIRGMDKES ILRKIIQVNG
510 520 530 540 550
KLIQGENPSR GRRAHLKQED NIWRYSLESE EVLHFAFPTD SESYNELALD
560 570 580 590 600
GLGLVPIKSP EIQIKHSYPY FTLKVPQLYK IKGYHPFSVN KSSTNYRLQK
610 620 630 640 650
LARPLKHGAE DEVTTIITIP KKDTTPLSAK PSILSMKPPE GLAMSVEYDP
660 670 680 690 700
LYIFNPSPGL FAVKHPLTYA ETLIDYHLCS HPKYKYTQES HMGSSIPLTQ
710 720 730 740 750
RQFLHHTDII PGIMNWKKFQ PLVFSSMSDP SMVEATQRSD WYSSVMLPID
760 770 780 790 800
VPAPLEDLPE EDRLETTERD LCDQGIEVML TPEMVQVEFP MLIHRDSKKE
810 820 830
KDFKDSTQLP EKVGERVQEE MKNLRSKALN TYLILD
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V015 | G3V015_MOUSE | Cilia- and flagella-associated prot... | Cfap221 Gm101 | 178 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF632061 mRNA Translation: ABR25260.1 |
CCDSi | CCDS48340.1 |
RefSeqi | NP_001108546.1, NM_001115074.1 XP_011246281.1, XM_011247979.2 XP_017175371.1, XM_017319882.1 XP_017175374.1, XM_017319885.1 |
Genome annotation databases
Ensembli | ENSMUST00000037840; ENSMUSP00000037703; ENSMUSG00000036962 ENSMUST00000174370; ENSMUSP00000134576; ENSMUSG00000036962 |
GeneIDi | 226356 |
KEGGi | mmu:226356 |
UCSCi | uc011wqu.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF632061 mRNA Translation: ABR25260.1 |
CCDSi | CCDS48340.1 |
RefSeqi | NP_001108546.1, NM_001115074.1 XP_011246281.1, XM_011247979.2 XP_017175371.1, XM_017319882.1 XP_017175374.1, XM_017319885.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000134576 |
PTM databases
iPTMneti | A9Q751 |
PhosphoSitePlusi | A9Q751 |
Proteomic databases
PaxDbi | A9Q751 |
PRIDEi | A9Q751 |
ProteomicsDBi | 289326 |
Protocols and materials databases
Antibodypediai | 48000, 54 antibodies from 10 providers |
Genome annotation databases
Ensembli | ENSMUST00000037840; ENSMUSP00000037703; ENSMUSG00000036962 ENSMUST00000174370; ENSMUSP00000134576; ENSMUSG00000036962 |
GeneIDi | 226356 |
KEGGi | mmu:226356 |
UCSCi | uc011wqu.1, mouse |
Organism-specific databases
CTDi | 200373 |
MGIi | MGI:2684947, Cfap221 |
VEuPathDBi | HostDB:ENSMUSG00000036962 |
Phylogenomic databases
eggNOGi | ENOG502QT0T, Eukaryota |
GeneTreei | ENSGT00390000006925 |
HOGENOMi | CLU_020964_0_0_1 |
InParanoidi | A9Q751 |
OMAi | IQVEFPM |
OrthoDBi | 1411975at2759 |
PhylomeDBi | A9Q751 |
TreeFami | TF328807 |
Miscellaneous databases
BioGRID-ORCSi | 226356, 0 hits in 63 CRISPR screens |
ChiTaRSi | Cfap221, mouse |
PROi | PR:A9Q751 |
RNActi | A9Q751, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000036962, Expressed in testis and 67 other tissues |
Genevisiblei | A9Q751, MM |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR029676, Gm101 IPR013783, Ig-like_fold |
PANTHERi | PTHR46500, PTHR46500, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PCDP1_MOUSE | |
Accessioni | A9Q751Primary (citable) accession number: A9Q751 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 15, 2010 |
Last sequence update: | February 5, 2008 | |
Last modified: | February 23, 2022 | |
This is version 81 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families