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Protein

Neuraminidase

Gene

NA

Organism
Influenza A virus (A/open-billed stork/Nakhonsawan/BBA2611M/05(H5N1))
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.UniRule annotationSAAS annotation

Cofactori

Ca2+UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidaseUniRule annotationSAAS annotation, Hydrolase
LigandCalciumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Protein family/group databases

CAZyiGH34 Glycoside Hydrolase Family 34

Names & Taxonomyi

Protein namesi
Recommended name:
NeuraminidaseUniRule annotationSAAS annotation (EC:3.2.1.18UniRule annotationSAAS annotation)
Gene namesi
Name:NAUniRule annotationImported
OrganismiInfluenza A virus (A/open-billed stork/Nakhonsawan/BBA2611M/05(H5N1))Imported
Taxonomic identifieri430728 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesOrthomyxoviridaeAlphainfluenzavirus
Proteomesi
  • UP000142212 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 45HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membraneUniRule annotationSAAS annotation, Host membrane, Membrane, VirionUniRule annotationSAAS annotation

PTM / Processingi

Post-translational modificationi

N-glycosylated.UniRule annotation

Keywords - PTMi

Disulfide bondSAAS annotation, GlycoproteinUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliA9P4R3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 34 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

CDDicd15483 Influenza_NA, 1 hit
HAMAPiMF_04071 INFV_NRAM, 1 hit
InterProiView protein in InterPro
IPR001860 Glyco_hydro_34
IPR033654 Sialidase_Influenza_A/B
IPR036278 Sialidase_sf
PfamiView protein in Pfam
PF00064 Neur, 1 hit
SUPFAMiSSF50939 SSF50939, 1 hit

Sequencei

Sequence statusi: Fragment.

A9P4R3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LVFREQKQEF KMNPNKKIIT IGSICMVTGM VSLMLQIGNL ISIWVSHSIH
60 70 80 90 100
TGNQHKAEPI SNTNLLTEKA VASVKLAGNS SLCPINGWAV YSKDNSIRIG
110 120 130 140 150
SKGDVFVVRE PFISCSHLEC RTFFLTQGAL LNDKHSNGTV KDRSPHRTLM
160 170 180 190 200
SCPVGEAPSP YNSRFESVAW SASACHDGTS WLTIGISGPN NGAVAVLKYN
210 220 230 240 250
GIITDTIKSW RNNILRTQES ECACVNGFCF TVMTDGPSNG QASHKIFKME
260 270 280 290 300
KGKVVKSVEL DAPNYHYEEC SCYPDAGEIT CVCRDNWHGS NRPWVSFNQN
310 320 330 340 350
LEYQIGYICS GVFGDNPRPN DGAGSCGPVA SNGAYGVKGF SFKYGNGVWI
360 370 380 390 400
GRTKSTNSRS GFEMIWDPNG WTETDSSFSV KQDIVAITDW SGYSGSFVQH
410 420 430 440 450
PELTGLDCIR PCFWVELIRG RPKESTIWTS GSSISFCGVN SDTVGWSWPD
460
GAELPFTIDK
Length:460
Mass (Da):50,465
Last modified:February 5, 2008 - v1
Checksum:i063D8289170D489B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF112332 Viral cRNA Translation: ABO34209.1

Similar proteinsi

Entry informationi

Entry nameiA9P4R3_9INFA
AccessioniPrimary (citable) accession number: A9P4R3
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: April 25, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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