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Protein

Neuraminidase

Gene

NA

Organism
Influenza A virus (A/open-billed stork/Nakhonsawan/BBD2316F/05(H5N1))
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.UniRule annotationSAAS annotation

Cofactori

Ca2+UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidaseUniRule annotationSAAS annotation, Hydrolase
LigandCalciumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NeuraminidaseUniRule annotationSAAS annotation (EC:3.2.1.18UniRule annotationSAAS annotation)
Gene namesi
Name:NAUniRule annotationImported
OrganismiInfluenza A virus (A/open-billed stork/Nakhonsawan/BBD2316F/05(H5N1))Imported
Taxonomic identifieri430737 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesOrthomyxoviridaeAlphainfluenzavirus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 44HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membraneUniRule annotationSAAS annotation, Host membrane, Membrane, VirionUniRule annotationSAAS annotation

PTM / Processingi

Post-translational modificationi

N-glycosylated.UniRule annotation

Keywords - PTMi

Disulfide bondSAAS annotation, GlycoproteinUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 34 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

CDDicd15483 Influenza_NA, 1 hit
HAMAPiMF_04071 INFV_NRAM, 1 hit
InterProiView protein in InterPro
IPR001860 Glyco_hydro_34
IPR033654 Sialidase_Influenza_A/B
IPR036278 Sialidase_sf
PfamiView protein in Pfam
PF00064 Neur, 1 hit
SUPFAMiSSF50939 SSF50939, 1 hit

Sequencei

Sequence statusi: Fragment.

A9P4Q6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
GLREQKQEFK MNPNKKIITI GSICMVTGMV SLMLQIGNLI SIWVSHSIHT
60 70 80 90 100
GNQHKAEPIS NTNLLTEKAV ASVKLAGNSS LCPINGWAVY SKDNSIRIGS
110 120 130 140 150
KGDVFVVREP FISYSHLECR TFFLTQGALL NDKHSNGTVK DRSPHRTLMS
160 170 180 190 200
CPVGEAPSPY NSRFESVAWS ASACHDGTSW LTIGISGPDN GAVAVLKYNG
210 220 230 240 250
IITDTIKSWR NNILRTQESE CACVNGFCFT VMTDGPSNGQ ASHKIFKMEK
260 270 280 290 300
GKVVKSVELD APNYHYEECS CYPDAGEITC VCRDNWHGSN RPWVSFNQNL
310 320 330 340 350
EYQIGYICSG VFGDNPRPND GAGSCGPVSS NGAYGVKGFS FKYGNGVWIG
360 370 380 390 400
RTKSTNSRSG FEMIWDPNGW TETDSSFSVK QDIVAITDWS GYSGSFVQHP
410 420 430 440 450
ELTGLDCIRP CFWVELIRGR PKESTIWTSG SSISFCGVNS DTVGWSWPDG

AELPFTIDK
Length:459
Mass (Da):50,353
Last modified:February 5, 2008 - v1
Checksum:i8A1843A30037040F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF112325 Viral cRNA Translation: ABO34202.1

Similar proteinsi

Entry informationi

Entry nameiA9P4Q6_9INFA
AccessioniPrimary (citable) accession number: A9P4Q6
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: April 25, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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